US4217445A
Expired / Lapsed
US
⏱️ 0.0 years remaining
5-Oxy-substituted derivatives of Psoralene useful in dermatology
Assignee: Fotobio Holding AG
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Filing: 1977-05-26
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Granted: 1980-08-12
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Expires: 1997-05-26
Abstract
Abstract An improved process for obtaining 5-methoxy-psoralene from bergamot oil, a method for preparing the compound 5-hydroxy-psoralene from 5-methoxy-psoralene and a method of making novel psoralene derivatives by replacing the hydrogen atom of the 5-hydroxy group with an R group are disclosed. These compounds are prepared by reacting the 5-hydroxy-psoralene with a halide RX in the presence of sodium hydride. Compounds of particular interest are those of which the radical R is: alkanoyl of not more than 10 carbon atoms; orthoacetoxy-benzoyl; αthenoyl; O,O diethyl-phosphono; diethylaminoethyl, and 2'3'4'6' tetra α acetyl D-gluco pyranosyl.
Inventors
- 👤 Eckhard Nikolaiski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 07:47
CPC Classifications
C; C07; C07D; C07D493/00; C07D493/02; C07D493/04; A; A61; A61P; A61P17/00; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6561; C07H; C07H17/00; C07H17/04
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
39 words
RO substituted psoralenes of the formula ##STR11## wherein R is a radical selected from the group consisting of alkanoyl of not more than 10 carbon atoms, ortho-acetoxy-benzoyl, α thenoyl O,O diethyl-phosphono, diethylaminoethyl, and 2'3'4'6' tetra α acetyl D-gluco pyranosyl.
Claim 2
Dependent Claim
39 words
RO substituted psoralenes of the formula ##STR11## wherein R is a radical selected from the group consisting of alkanoyl of not more than 10 carbon atoms, ortho-acetoxy-benzoyl, α thenoyl O,O diethyl-phosphono, diethylaminoethyl, and 2'3'4'6' tetra α acetyl D-gluco pyranosyl.
Claim 3
Dependent Claim
9 words
A compound according to claim 1 which is n-decanoyl-5-oxy-psoralene.
Claim 4
Dependent Claim
9 words
A compound according to claim 1 which is (ortho-acetoxy)-benzoyl-5-oxy-psoralene.
Claim 5
Dependent Claim
9 words
A compound according to claim 1 which is β-diethyl-amino-5-ethoxy-psoralene.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 which is β-diethyl-amino-5-ethoxy-psoralene hydrochloride.
Claim 7
Dependent Claim
9 words
A compound according to clai 1 which is (O,O-diethyl-phosphono)-5-oxy-psoralene.
Claim 8
Dependent Claim
9 words
A compound according to clai 1 which is (O,O-diethyl-phosphono)-5-oxy-psoralene.
Claim 9
Dependent Claim
13 words
A compound according to claim 1 which is 2'3'4'6' tetra α acetyl D-gluco-pyranosyl-5-oxy-psoralene.
Claim 10
Dependent Claim
9 words
A compound according to claim 1 which is α-thenoyl-5-oxy-psoralene.
References Cited (Backward Citations)
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US2345635A
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US2889337A
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US3201421A
Cited
US3553236A
Cited
US3985896A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-08-12 | 1984-02-11 | 1984-08-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-08-12 | 1988-02-11 | 1988-08-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-08-12 | 1992-02-11 | 1992-08-12 | $7700.00 | Window Closed / Lapsed |