US4216209A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tripeptide angiotensin converting enzyme inhibitors
Assignee: Wyeth LLC
•
Filing: 1979-03-19
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Granted: 1980-08-05
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Expires: 1999-03-19
Abstract
Abstract Compounds of the formula HSCH 2 CHR 1 CO--Pro--R 2 --R 3 --OH in which R 1 is hydrogen or lower alkyl, R 2 is an amino acid residue exclusive of prolyl and R 3 is an amino acid residue exclusive of glutamyl are useful for alleviating angiotensin related hypertension.
Inventors
- 👤 Francesco Bellini
- 👤 Hans U. Immer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 11:24
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06139; C07K5/06165; C07K5/06008; C07K5/06017; C07K5/0606; C07K5/06069; C07K5/08; C07K5/0821; C07K5/0823; Y; Y10; Y10S; Y10S530/00; Y10S530/80
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
83 words
A compound of formula I HSCH.sub.2 CHR.sup.1 CO-Pro-R.sup.2 -R.sup.3 -OH in which R 1 is hydrogen or lower alkyl; R 2 is an amino acid residue of alanine, arginine, cysteine, glycine, histidine, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, serine, threonine, tryptophan, tyrosine or valine; and R 3 is an amino acid residue of alanine, arginine, cysteine, glycine, histidine, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine or valine; or a pharmaceutically acceptable salt thereof with an inorganic or organic base.
Claim 2
Dependent Claim
83 words
A compound of formula I HSCH.sub.2 CHR.sup.1 CO-Pro-R.sup.2 -R.sup.3 -OH in which R 1 is hydrogen or lower alkyl; R 2 is an amino acid residue of alanine, arginine, cysteine, glycine, histidine, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, serine, threonine, tryptophan, tyrosine or valine; and R 3 is an amino acid residue of alanine, arginine, cysteine, glycine, histidine, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine or valine; or a pharmaceutically acceptable salt thereof with an inorganic or organic base.
Claim 3
Dependent Claim
13 words
The compound of claim 1 in which R 1 is hydrogen or methyl.
Claim 4
Dependent Claim
33 words
The compound of claim 1 in which R 1 is hydrogen or methyl, and R 2 and R 3 are selected from the amino acid residues of arginine, histidine, leucine, phenylalanine and serine.
Claim 5
Dependent Claim
6 words
N-[N-[1-(3-Mercapto-1-oxopropyl)prolyl]histidyl]leucine, as claimed in claim 1.
Claim 6
Dependent Claim
6 words
N-[N-[1-(3-Mercapto-2-D-methyl-1-oxopropyl)prolyl]histidyl]leucine, as claimed in claim 1.
Claim 7
Dependent Claim
6 words
N-[N-[1-(3-Mercapto-2-D-methyl-1-oxopropyl)prolyl]seryl]leucine, as claimed in claim 1.
Claim 8
Dependent Claim
14 words
A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
26 words
A method for alleviating angiotensin related hypertension in a hypertensive mammal which comprises administering to said mammal an effective dose of the compound of claim 1.
References Cited (Backward Citations)
US4105776A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-08-05 | 1984-02-04 | 1984-08-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-08-05 | 1988-02-04 | 1988-08-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-08-05 | 1992-02-04 | 1992-08-05 | $7700.00 | Window Closed / Lapsed |