Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
208 words
A process for preparing a stable serum protein composition of improved passive immunilogical properties, suitable for use in prophylactic therapy and the strengthening of the human body weakened by loss of blood, wherein the starting product for said process is more readily available than the human blood which is used in conventional processes for obtaining serum protein compositions, said process comprising the steps of: (a) mixing and suspending plasma fractions together in a suitable physiologically acceptable solvent to produce a mixture, said fractions and the amounts thereof being selected in such a manner that an immunologically effective amount of active antibodies is incorporated into the mixture, said fractions being characterized as equivalent to: (i) COHN-fractions IV and II/III, or (ii) fractions II, III and IV according to Steinbuck; (b) removing the insoluble components remaining in the mixture and recovering the supernatant; (c) stabilizing and purifying the super natant by removing storage instable proteins, thereafter subjecting the supernatant to a clarifying filtration and concentrating the resulting solution to remove substantially all blood constituents having a molecular weight of less than 10,000 to produce a purified solution; (d) standardizing the purified solution to the physiological conditions of the isotonic parameters according to human blood by means of a NaCl solution.
Claim 2
Dependent Claim
208 words
A process for preparing a stable serum protein composition of improved passive immunilogical properties, suitable for use in prophylactic therapy and the strengthening of the human body weakened by loss of blood, wherein the starting product for said process is more readily available than the human blood which is used in conventional processes for obtaining serum protein compositions, said process comprising the steps of: (a) mixing and suspending plasma fractions together in a suitable physiologically acceptable solvent to produce a mixture, said fractions and the amounts thereof being selected in such a manner that an immunologically effective amount of active antibodies is incorporated into the mixture, said fractions being characterized as equivalent to: (i) COHN-fractions IV and II/III, or (ii) fractions II, III and IV according to Steinbuck; (b) removing the insoluble components remaining in the mixture and recovering the supernatant; (c) stabilizing and purifying the super natant by removing storage instable proteins, thereafter subjecting the supernatant to a clarifying filtration and concentrating the resulting solution to remove substantially all blood constituents having a molecular weight of less than 10,000 to produce a purified solution; (d) standardizing the purified solution to the physiological conditions of the isotonic parameters according to human blood by means of a NaCl solution.
Claim 3
Dependent Claim
22 words
A process according to claim 1, wherein said fractions COHN-fractions are selected from the group consisting of fractions IV, III-1 and III-2.
Claim 4
Dependent Claim
39 words
A process according to claim 2, wherein said mixture comprises the following proportions of fractions: Fraction IV 30 to 80 percent by weight Fraction III-1 0 to 70 percent by weight Fraction III-2 0 to 70 percent by weight.
Claim 5
Dependent Claim
39 words
A process according to claim 3, wherein said mixture comprises the following proportions of fractions: Fraction IV 40 to 60 percent by weight Fraction III-1 20 to 30 percent by weight Fraction III-2 20 to 30 percent by weight.