US4213995A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Phenylimino-imidazolidines and salts thereof
Assignee: Boehringer Ingelheim GmbH
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Filing: 1979-02-12
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Granted: 1980-07-22
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Expires: 1999-02-12
Abstract
Abstract Compounds of the formula <IMAGE> wherein R is 2,6-dichloro-4-hydroxymethyl-phenyl; 2-chloro-4-methyl-5-amino-phenyl; 2,5-dichloro-4-methyl-phenyl; 2-chloro-4-methyl-5-nitro-phenyl; 2,3-dichloro-4-methyl-phenyl; 2-chloro-4-methyl-6-nitro-phenyl; 2-chloro-4-methyl-6-amino-phenyl; 2,4,6-trifluorophenyl; tetrafluoro-phenyl; or 3-bromo-4-fluoro-phenyl; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as hypotensives.
Inventors
- 👤 Helmut Stahle
- 👤 Herbert Koppe
- 👤 Werner Kummer
- 👤 Wolfgang Hoefke
- 👤 Ludwig Pichler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 13:35
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/04; C07D233/28; C07D233/44; C07D233/50; A; A61; A61P; A61P9/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
21 words
A compound of the formula ##STR5## wherein R is 2,6-dichloro-4-hydroxymethyl-phenyl or tetrafluoro-phenyl; or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
21 words
A compound of the formula ##STR5## wherein R is 2,6-dichloro-4-hydroxymethyl-phenyl or tetrafluoro-phenyl; or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
24 words
A hypotensive pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective hypotensive amount of a compound of claim 1.
Claim 4
Dependent Claim
33 words
The method of reducing the blood pressure of a warm-blooded animal in need thereof, which comprises enterally or parenterally administering to said animal an effective hypotensive amount of a compound of claim 1.
References Cited (Backward Citations)
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US3236857A
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BE653933A
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BE687657A
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FR1506408A
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US3595961A
Cited
BE705944A
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US3468887A
Cited
DE2356005A1
Cited
US4025607A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-07-22 | 1984-01-21 | 1984-07-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-07-22 | 1988-01-21 | 1988-07-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-07-22 | 1992-01-21 | 1992-07-22 | $7700.00 | Window Closed / Lapsed |