US4210667A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical preparations containing coumarin carboxylic acid derivatives
Assignee: Pfizer Inc
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Filing: 1979-04-19
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Granted: 1980-07-01
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Expires: 1999-04-19
Abstract
Abstract Preparations useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The preparations contain substituted and unsubstituted coumarin-4-carboxylic or acetic acid derivatives as the active ingredients.
Inventors
- 👤 Reinhard Sarges
- 👤 John L. Belletire
- 👤 Rodney C. Schnur
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 16:36
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/365; A61K31/366; A61K31/37
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
108 words
A pharmaceutical preparation useful for prophylactic or remedial treatment of diabetic cataracts, retinopathy, nephropathy or neuropathy in a diabetic patient, which comprises: a pharmaceutical carrier and a therapeutic amount of a coumarin carboxylic acid derivative selected from the group consisting of ##STR2## and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently selected from H or CH 3 ; X is H, CH 3 , F or Cl; and n is 0 or 1; provided that when R 1 is CH 3 , R 2 or R 3 is CH 3 .
Claim 2
Dependent Claim
108 words
A pharmaceutical preparation useful for prophylactic or remedial treatment of diabetic cataracts, retinopathy, nephropathy or neuropathy in a diabetic patient, which comprises: a pharmaceutical carrier and a therapeutic amount of a coumarin carboxylic acid derivative selected from the group consisting of ##STR2## and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently selected from H or CH 3 ; X is H, CH 3 , F or Cl; and n is 0 or 1; provided that when R 1 is CH 3 , R 2 or R 3 is CH 3 .
Claim 3
Dependent Claim
34 words
A preparation of claim 1 containing the derivative of Formula I wherein R 1 and R 3 are H; R 2 , R 4 and X are CH 3 ; and n is 1.
Claim 4
Dependent Claim
33 words
A preparation of claim 1 containing the derivative of Formula I wherein X, R 3 and R 4 are H; R 1 and R 2 are CH 3 ; and n is 1.
Claim 5
Dependent Claim
34 words
A preparation of claim 1 containing the derivative of Formula I wherein R 1 , R 3 , R 4 and X are H; R 2 is CH 3 ; and n is 1.
Claim 6
Dependent Claim
34 words
A preparation of claim 1 containing the derivative of Formula I wherein R 1 , R 3 and R 4 are H; R 2 and X are CH 3 ; and n is 1.
Claim 7
Dependent Claim
35 words
A preparation of claim 1 containing the derivative of Formula I wherein R 1 , R 2 and R 4 are H; R 3 is CH 3 ; X is Cl; and n is 0.
Claim 8
Dependent Claim
23 words
A preparation of claim 1 containing the derivative of Formula II wherein R 5 and R 6 are H; and X is Cl.
Claim 9
Dependent Claim
45 words
A preparation of claim 1 containing a mixture of the derivatives of Formula II wherein R 5 is H; R 6 is CH 3 ; and X is Cl and wherein R 6 is H; R 5 is CH 3 ; and X is Cl.
Claim 10
Dependent Claim
45 words
A method of prophylactically or remedially treating diabetic cataracts, retinopathy, nephropathy or neuropathy in a diabetic patient, which comprises: administering to the patient in a form suitable for oral, intravenous, intramuscular, subcutaneous, topical or ophthalmic dosage, a therapeutic amount of a derivative of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-07-01 | 1983-12-31 | 1984-07-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-07-01 | 1987-12-31 | 1988-07-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-07-01 | 1991-12-31 | 1992-07-01 | $7700.00 | Window Closed / Lapsed |