US4206222A
Expired / Lapsed
US
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Method for preparing a substance having properties against collagen diseases and products obtained
Assignee: Societe Civile Particuliere de Brevets Suffren
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Filing: 1978-08-08
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Granted: 1980-06-03
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Expires: 1998-08-08
Abstract
Abstract This invention relates to the chemical and pharmaceutical industries. An active agent is extracted from ferns with a water-alcohol mixture. The essential compound is a delta-lactone having 8 carbon atoms, obtained as a monomer and/or as polymers, and which may be under the form of a chelate salt. It is useful mainly as the active substance in drugs for the treatment of diseases accompanied by collagen alterations.
Inventors
- 👤 Jean Valetas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:40
CPC Classifications
C; C07; C07F; C07F3/00; C07F3/003; A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/365; A61K36/00; A61K36/11; A61K36/12; C07D; C07D309/00; C07D309/32
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
48 words
A method for preparing a substance having activity against collagen diseases, comprising submitting ferns to a water-alcoholic extraction effected using a water-alcohol mixture containing at least 20% of methanol, ethanol or propanol and purifying the extract by contacting it with activated charcoal or with a similar tannin absorbent.
Claim 2
Independent Claim
48 words
A method for preparing a substance having activity against collagen diseases, comprising submitting ferns to a water-alcoholic extraction effected using a water-alcohol mixture containing at least 20% of methanol, ethanol or propanol and purifying the extract by contacting it with activated charcoal or with a similar tannin absorbent.
Claim 3
Dependent Claim
30 words
A method according to claim 1, wherein aerial parts of ferns are previously dried and ground, then submitted to said extraction using a water-ethanol mixture containing at least 20% ethanol.
Claim 4
Dependent Claim
15 words
A method according to claim 2, wherein the ethanol content is from 40% to 95%.
Claim 5
Independent Claim
61 words
A method according to any of claims 1 to 3 further comprising concentrating said extract by evaporating the alcohol therefrom at a temperature from 25° C. to 75° C., further purifying said extract by contacting it with a cation-exchange resin in hydrogen form, neutralizing the purified extract to a pH from 3 to 7, and removing the thus precipitated insoluble materials.
Claim 6
Dependent Claim
31 words
A method according to claim 4, wherein said extract is neutralized by adding thereto calcium hydroxide to a pH from 4.5 to 6.5 and the thus precipitated insoluble materials are removed.
Claim 7
Dependent Claim
27 words
A method according to claim 5 further comprising precipitating a lactone calcium salt from said extract by adding thereto methanol or a mixture of methanol and ethanol.
Claim 8
Dependent Claim
12 words
A method according to claim 6 further comprising lyophilizing said calcium salt.
Claim 9
Dependent Claim
36 words
A method according to claim 4, 5, 6, or 7, further comprising treating an aqueous solution of said lactone calcium salt by chromatography to separate a monomer fraction having a molecular weight from 500 to 600.
Claim 10
Independent Claim
34 words
A method according to any of claims 6 to 8 further comprising contacting an aqueous solution of said lactone calcium salt with a cation-exchange resin in hydrogen form to obtain the corresponding acidic lactone.
Claim 11
Dependent Claim
16 words
A method according to claim 9 further comprising reacting said lactone with a pharmaceutically acceptable base.
Claim 12
Dependent Claim
19 words
A substance having activity against collagen diseases produced by the method according to any of claims 1 to 10.
Claim 13
Dependent Claim
28 words
A pharmaceutically active agent comprising at least one delta-lactone compound having 8 carbon atoms extractible from ferns by water-alcohol extraction, or a salt formed with pharmaceutically acceptable base.
Claim 14
Dependent Claim
28 words
A pharmaceutically active agent comprising at least one delta-lactone compound having 8 carbon atoms extractible from ferns by water-alcohol extraction, or a salt formed with pharmaceutically acceptable base.
Claim 15
Dependent Claim
28 words
A substance useful as an active agent against collagen alterations, constituted by a C 8 delta-lactone with the following formula ##STR5## as a monomer or chelate salt thereof.
Claim 16
Dependent Claim
28 words
A substance useful as an active agent against collagen alterations, constituted by a C 8 delta-lactone with the following formula ##STR5## as a monomer or chelate salt thereof.
Claim 17
Dependent Claim
14 words
A substance according to claim 13, constituted by a calcium salt having formula ##STR6##
Claim 18
Dependent Claim
37 words
A medicament against collagen alterations comprising unit doses from 5 to 100 mg of an active agent according to claim 1 or a substance according to any of claims 11 or 14 and a pharmaceutical acceptable carrier.
References Cited (Backward Citations)
US3584123A
Cited
US3839553A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-06-03 | 1983-12-03 | 1984-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-06-03 | 1987-12-03 | 1988-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-06-03 | 1991-12-03 | 1992-06-03 | $7700.00 | Window Closed / Lapsed |