US4205688A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for developing and measuring pulsed blood flow
Assignee: DOLL RES Inc
•
Filing: 1977-05-23
•
Granted: 1980-06-03
•
Expires: 1997-05-23
Abstract
Abstract A blood flowmeter responsive only to the pulsatile component of blood flow is combined with apparatus for converting normal blood flow in a limb to fully pulsated flow to provide accurate zero baseline and total flow information. Preferably, the arterial flow in a limb is fully pulsatized by inflating a pressure cuff, which surrounds the limb on the distal side of a flow sensor location, to a pressure at or slightly above the local diastolic pressure. Arterial flow in the limb is thereby occluded during the diastolic and post-diastolic period of each heart cycle, preventing any flow that otherwise typically occurs during this period. The resulting pulsatile flow during the higher pressure systolic period will increase to compensate for any lost residual forward flow during the post-diastolic period; so that the total net forward flow with the cuff pressurized is approximately the same as the total net forward flow without the cuff pressurized. The altered flow is totally pulsatile, however. Subtraction of the integrated flow measured without cuff pressure from the integrated flow measured with the cuff pressurized yields a value approximately equal to any residual diastolic flow, which otherwise could not be measured by certain non-invasive magnetic flowmeters.
Inventors
- 👤 Herbert H. Hauser
- 👤 Marie-Lucienne Tannieres
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:12
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/12; A61B17/132; A61B17/135; A61B17/1355; A61B5/00; A61B5/02; A61B5/026; A61B5/0265; A61B5/24; A61B5/316; A61B5/318; A61B5/346; A61B5/349; A61B5/352
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
143 words
A method for measuring blood flow in a limb of a living being comprising: (a) periodically occluding the arterial blood vessels at a predetermined location along a limb of a living being to stop the flow of blood through said vessels, the duration of each occlusion being approximately coincident with the diastolic and post-diastolic period of a corresponding heart cycle of the living being; (b) permitting a nonconstant unidirectional blood flow pulse through said arterial vessels during each interval between successive occlusions, each interval being approximately coincident with the systolic period of a heart cycle of the living being; (c) detecting signals proportional to the nonconstant pulsatile flow through said arterial blood vessels during a predetermined plurality of said intervals; and (d) processing said detected signals to obtain the time-integrated total flow of blood through said arterial blood vessels for the detecting period.
Claim 2
Independent Claim
143 words
A method for measuring blood flow in a limb of a living being comprising: (a) periodically occluding the arterial blood vessels at a predetermined location along a limb of a living being to stop the flow of blood through said vessels, the duration of each occlusion being approximately coincident with the diastolic and post-diastolic period of a corresponding heart cycle of the living being; (b) permitting a nonconstant unidirectional blood flow pulse through said arterial vessels during each interval between successive occlusions, each interval being approximately coincident with the systolic period of a heart cycle of the living being; (c) detecting signals proportional to the nonconstant pulsatile flow through said arterial blood vessels during a predetermined plurality of said intervals; and (d) processing said detected signals to obtain the time-integrated total flow of blood through said arterial blood vessels for the detecting period.
Claim 3
Independent Claim
147 words
A method for measuring blood flow in a limb of a living being comprising: (a) applying presssure at a predetermined location along a limb of a living being for a predetermined period of time, said pressure being at least equal to and no more than slightly exceeding the diastolic pressure at said location, to stop the flow of blood through arterial vessels in the limb by occluding said arterial vessels when their internal pressure is less than said applied pressure; (b) permitting nonconstant blood flow through said arterial vessels during each interval between successive occlusions; (c) detecting the amplitude of signals proportional to the nonconstant flow rate through said arterial blood vessels during each interval between a plurality of successive occlusions; and (d) processing said detected signals to obtain the total flow of blood through said arterial blood vessels during the time spanned by said successive occlusions.
Claim 4
Independent Claim
147 words
A method for measuring blood flow in a limb of a living being comprising: (a) applying presssure at a predetermined location along a limb of a living being for a predetermined period of time, said pressure being at least equal to and no more than slightly exceeding the diastolic pressure at said location, to stop the flow of blood through arterial vessels in the limb by occluding said arterial vessels when their internal pressure is less than said applied pressure; (b) permitting nonconstant blood flow through said arterial vessels during each interval between successive occlusions; (c) detecting the amplitude of signals proportional to the nonconstant flow rate through said arterial blood vessels during each interval between a plurality of successive occlusions; and (d) processing said detected signals to obtain the total flow of blood through said arterial blood vessels during the time spanned by said successive occlusions.
Claim 5
Independent Claim
165 words
A method for measuring blood flow in a limb of a living being comprising: (a) periodically applying uniform pressure around the circumference of a limb of a living being at a predetermined location along said limb, said pressure being at least equal to the diastolic pressure at said location and being applied only during the diastolic and post-diastolic portion of each of a plurality of successive heart cycles of the living being, to stop the flow of blood through arterial vessels in the limb during said diastolic and post-diastolic portion of each heart cycle; (b) releasing the pressure during the systolic portion of each heart cycle to permit a nonconstant unidirectional blood flow pulse through said arterial vessels during said systolic portion of each heart cycle; (c) detecting signals proportional to the nonconstant flow pulses through said arterial blood vessels; and (d) processing said detected signals to obtain a time-averaged flow rate of blood through said blood vessels over said plurality of successive heart cycles.
Claim 6
Independent Claim
165 words
A method for measuring blood flow in a limb of a living being comprising: (a) periodically applying uniform pressure around the circumference of a limb of a living being at a predetermined location along said limb, said pressure being at least equal to the diastolic pressure at said location and being applied only during the diastolic and post-diastolic portion of each of a plurality of successive heart cycles of the living being, to stop the flow of blood through arterial vessels in the limb during said diastolic and post-diastolic portion of each heart cycle; (b) releasing the pressure during the systolic portion of each heart cycle to permit a nonconstant unidirectional blood flow pulse through said arterial vessels during said systolic portion of each heart cycle; (c) detecting signals proportional to the nonconstant flow pulses through said arterial blood vessels; and (d) processing said detected signals to obtain a time-averaged flow rate of blood through said blood vessels over said plurality of successive heart cycles.
Claim 7
Independent Claim
181 words
A method for measuring blood flow in a limb of a living being comprising: (a) periodically applying uniform pressure around the circumference of a limb of a living being at a predetermined location along said limb, said pressure being at least equal to the diastolic pressure at said location and being applied only during the diastolic and post-diastolic portion of each of a plurality of successive heart cycles of the living being; to stop the flow of blood through arterial vessels in the limb during said diastolic and post-diastolic portion of each heart cycle; (b) releasing the pressure during the systolic portion of each heart cycle to permit a nonconstant unidirectional blood flow pulse through said arterial vessels during said systolic portion of each heart cycle; (c) detecting signals proportional to the nonconstant flow pulses through said arterial blood vessels; and (d) cumulatively storing said detected signals for a predetermined period of time corresponding to said plurality of successive heart cycles to obtain a time-integrated signal proportional to the total flow of arterial blood at said location during the predetermined time.
Claim 8
Independent Claim
181 words
A method for measuring blood flow in a limb of a living being comprising: (a) periodically applying uniform pressure around the circumference of a limb of a living being at a predetermined location along said limb, said pressure being at least equal to the diastolic pressure at said location and being applied only during the diastolic and post-diastolic portion of each of a plurality of successive heart cycles of the living being; to stop the flow of blood through arterial vessels in the limb during said diastolic and post-diastolic portion of each heart cycle; (b) releasing the pressure during the systolic portion of each heart cycle to permit a nonconstant unidirectional blood flow pulse through said arterial vessels during said systolic portion of each heart cycle; (c) detecting signals proportional to the nonconstant flow pulses through said arterial blood vessels; and (d) cumulatively storing said detected signals for a predetermined period of time corresponding to said plurality of successive heart cycles to obtain a time-integrated signal proportional to the total flow of arterial blood at said location during the predetermined time.
Claim 9
Independent Claim
159 words
A method for measuring blood flow in a limb of a living being comprising: (a) applying uniform pressure around the circumference of a limb of a living being at a predetermined location along said limb, said pressure being at least equal to the diastolic pressure and substantially less than the systolic pressure at said location and being applied continuously for a predetermined period of time equal to at least a plurality of heart cycles of the living being, thereby occluding the arterial blood vessels in the limb during the diastolic and post-diastolic portion of each heart cycle during said predetermined period of time while permitting nonconstant blood flow through said arterial vessels during each interval between successive occlusions; (b) sensing the amplitude of signals proportional to the nonconstant flow through said arterial blood vessels; and (c) processing said sensed signals to obtain the average flow rate of blood through said arterial blood vessels during said predetermined period of time.
Claim 10
Independent Claim
159 words
A method for measuring blood flow in a limb of a living being comprising: (a) applying uniform pressure around the circumference of a limb of a living being at a predetermined location along said limb, said pressure being at least equal to the diastolic pressure and substantially less than the systolic pressure at said location and being applied continuously for a predetermined period of time equal to at least a plurality of heart cycles of the living being, thereby occluding the arterial blood vessels in the limb during the diastolic and post-diastolic portion of each heart cycle during said predetermined period of time while permitting nonconstant blood flow through said arterial vessels during each interval between successive occlusions; (b) sensing the amplitude of signals proportional to the nonconstant flow through said arterial blood vessels; and (c) processing said sensed signals to obtain the average flow rate of blood through said arterial blood vessels during said predetermined period of time.
Claim 11
Independent Claim
168 words
A method for measuring blood flow in a limb of a living being comprising: (a) applying uniform pressure around the circumference of a limb of a living being at a predetermined location along said limb, said pressure being at least equal to the diastolic pressure and substantially less than the systolic pressure at said location and being applied continuously for a predetermined period of time equal to at least a plurality of heart cycles of the living being, thereby occluding the arterial blood vessels in the limb during the diastolic and post-diastolic portion of each heart cycle during said predetermined period of time while permitting nonconstant blood flow through said arterial vessels during each interval between successive occlusions; (b) sensing the amplitude of signals proportional to the nonconstant flow through said arterial blood vessels; and (c) cumulatively storing the sensed signals over said predetermined period of time to provide a time-integrated signal proportional to the average arterial blood flow at said location for said predetermined period of time.
Claim 12
Independent Claim
168 words
A method for measuring blood flow in a limb of a living being comprising: (a) applying uniform pressure around the circumference of a limb of a living being at a predetermined location along said limb, said pressure being at least equal to the diastolic pressure and substantially less than the systolic pressure at said location and being applied continuously for a predetermined period of time equal to at least a plurality of heart cycles of the living being, thereby occluding the arterial blood vessels in the limb during the diastolic and post-diastolic portion of each heart cycle during said predetermined period of time while permitting nonconstant blood flow through said arterial vessels during each interval between successive occlusions; (b) sensing the amplitude of signals proportional to the nonconstant flow through said arterial blood vessels; and (c) cumulatively storing the sensed signals over said predetermined period of time to provide a time-integrated signal proportional to the average arterial blood flow at said location for said predetermined period of time.
Claim 13
Independent Claim
164 words
A method for measuring blood flow in a limb of a living being comprising: (a) detecting signals proportional to the blood flow through arterial blood vessels at a predetermined location on a limb of a living being; (b) cumulatively storing the signals detected in step (a) for a selected number of heart cycles to provide a first timeintegrated signal proportional to the average net unrestricted arterial blood flow into the limb at said location; (c) occluding the arterial blood vessels at said location during only the diastolic and post-diastolic portions of an additional number of heart cycles; (d) cumulatively storing the signals detected during step (c) for said additional number of heart cycles to provide a second time-integrated signal proportional to the average arterial blood flow at said location; and (e) subtracting the second signal obtained in step (d) from the first signal obtained in step (b) to provide a third signal proportional to the average non-pulsatile residual arterial blood flow at said location.
Claim 14
Independent Claim
164 words
A method for measuring blood flow in a limb of a living being comprising: (a) detecting signals proportional to the blood flow through arterial blood vessels at a predetermined location on a limb of a living being; (b) cumulatively storing the signals detected in step (a) for a selected number of heart cycles to provide a first timeintegrated signal proportional to the average net unrestricted arterial blood flow into the limb at said location; (c) occluding the arterial blood vessels at said location during only the diastolic and post-diastolic portions of an additional number of heart cycles; (d) cumulatively storing the signals detected during step (c) for said additional number of heart cycles to provide a second time-integrated signal proportional to the average arterial blood flow at said location; and (e) subtracting the second signal obtained in step (d) from the first signal obtained in step (b) to provide a third signal proportional to the average non-pulsatile residual arterial blood flow at said location.
Claim 15
Independent Claim
231 words
A method for measuring blood flow in a limb of a living being comprising: (a) detecting signals proportional to the blood flow through arterial blood vessels at a predetermined location on a limb of a living being; (b) cumulatively storing the signals detected in step (a) for a selected number of heart cycles to provide a first timeintegrated signal proportional to the average net unrestricted arterial blood flow into the limb at said location; (c) applying uniform pressure around the circumference of the limb at said location during at least the diastolic and post-diastolic portion of each heart cycle during an additional number of heart cycles, said pressure being equal to at least the diastolic pressure at said location so as to occlude the arterial blood vessels in the limb at said location during only the diastolic and post-diastolic portion of each heart cycle; (d) detecting signals proportional to the blood flow through the arterial blood vessels during said additional number of heart cycles; (e) cumulatively storing the signals detected during step (d) for said additional number of heart cycles to provide a second time-integrated signal proportional to the average arterial blood flow at said location; and (f) subtracting the second signal obtained in step (e) from the first signal obtained in step (b) to provide a third signal proportional to the average non-pulsatile residual arterial blood flow at said location.
Claim 16
Independent Claim
231 words
A method for measuring blood flow in a limb of a living being comprising: (a) detecting signals proportional to the blood flow through arterial blood vessels at a predetermined location on a limb of a living being; (b) cumulatively storing the signals detected in step (a) for a selected number of heart cycles to provide a first timeintegrated signal proportional to the average net unrestricted arterial blood flow into the limb at said location; (c) applying uniform pressure around the circumference of the limb at said location during at least the diastolic and post-diastolic portion of each heart cycle during an additional number of heart cycles, said pressure being equal to at least the diastolic pressure at said location so as to occlude the arterial blood vessels in the limb at said location during only the diastolic and post-diastolic portion of each heart cycle; (d) detecting signals proportional to the blood flow through the arterial blood vessels during said additional number of heart cycles; (e) cumulatively storing the signals detected during step (d) for said additional number of heart cycles to provide a second time-integrated signal proportional to the average arterial blood flow at said location; and (f) subtracting the second signal obtained in step (e) from the first signal obtained in step (b) to provide a third signal proportional to the average non-pulsatile residual arterial blood flow at said location.
Claim 17
Independent Claim
250 words
A method for measuring blood flow in a limb of a living being comprising: (a) detecting signals proportional to the blood flow through arterial blood vessels at a predetermined location on a limb of a living being; (b) cumulatively storing the signals detected in step (a) for a predetermined period of time to provide a first timeintegrated signal proportional to the average net unrestricted arterial blood flow into the limb at said location; (c) applying uniform pressure around the circumference of the limb at said location during only the diastolic and postdiastolic portion of each heart cycle of the living being, said pressure being equal to at least the diastolic pressure at said location so as to occlude the arterial blood vessels in the limb at said location during the diastolic and post-diastolic portion of each heart cycle during an additional period of time; (d) releasing the pressure around said limb during the systolic portion of each heart cycle during said additional period of time; (e) detecting signals proportional to the blood flow through the arterial blood vessels in the limb during step (d); (f) cumulatively storing the signals detected during step (e) for said additional period of time to provide a second time-integrated signal proportional to the average arterial blood flow at said location; and (g) subtracting the second signal obtained in step (f) from the first signal obtained in step (b) to provide a third signal proportional to the average non-pulsatile residual arterial blood flow at said location.
Claim 18
Independent Claim
250 words
A method for measuring blood flow in a limb of a living being comprising: (a) detecting signals proportional to the blood flow through arterial blood vessels at a predetermined location on a limb of a living being; (b) cumulatively storing the signals detected in step (a) for a predetermined period of time to provide a first timeintegrated signal proportional to the average net unrestricted arterial blood flow into the limb at said location; (c) applying uniform pressure around the circumference of the limb at said location during only the diastolic and postdiastolic portion of each heart cycle of the living being, said pressure being equal to at least the diastolic pressure at said location so as to occlude the arterial blood vessels in the limb at said location during the diastolic and post-diastolic portion of each heart cycle during an additional period of time; (d) releasing the pressure around said limb during the systolic portion of each heart cycle during said additional period of time; (e) detecting signals proportional to the blood flow through the arterial blood vessels in the limb during step (d); (f) cumulatively storing the signals detected during step (e) for said additional period of time to provide a second time-integrated signal proportional to the average arterial blood flow at said location; and (g) subtracting the second signal obtained in step (f) from the first signal obtained in step (b) to provide a third signal proportional to the average non-pulsatile residual arterial blood flow at said location.
Claim 19
Independent Claim
236 words
A method for measuring blood flow in a limb of a living being comprising: (a) detecting signals proportional to the blood flow through arterial blood vessels at a predetermined location on a limb of a living being; (b) cumulatively storing the signals detected in step (a) for a selected number of heart cycles to provide a first timeintegrated signal proportional to the average net unrestricted arterial blood flow into the limb at said location; (c) applying uniform pressure around the circumference of the limb at said location steadily during an additional number of heart cycles, said pressure being at least equal to and no more than slightly greater than the diastolic pressure at said location so as to occlude the arterial blood vessels during the diastolic and post-diastolic portion and to permit pulsatile arterial blood flow during the systolic portion of each of the additional number of heart cycles; (d) detecting signals proportional to the blood flow through the arterial blood vessels during said additional number of heart cycles; (e) cumulatively storing the signals detected during step (d) for said additional number of heart cycles to provide a second time-integrated signal proportional to the average arterial blood flow at said location; and (f) subtracting the second signal obtained in step (d) from the first signal obtained in step (b) to provide a third signal proportional to the average non-pulsatile residual arterial blood flow at said location.
Claim 20
Independent Claim
236 words
A method for measuring blood flow in a limb of a living being comprising: (a) detecting signals proportional to the blood flow through arterial blood vessels at a predetermined location on a limb of a living being; (b) cumulatively storing the signals detected in step (a) for a selected number of heart cycles to provide a first timeintegrated signal proportional to the average net unrestricted arterial blood flow into the limb at said location; (c) applying uniform pressure around the circumference of the limb at said location steadily during an additional number of heart cycles, said pressure being at least equal to and no more than slightly greater than the diastolic pressure at said location so as to occlude the arterial blood vessels during the diastolic and post-diastolic portion and to permit pulsatile arterial blood flow during the systolic portion of each of the additional number of heart cycles; (d) detecting signals proportional to the blood flow through the arterial blood vessels during said additional number of heart cycles; (e) cumulatively storing the signals detected during step (d) for said additional number of heart cycles to provide a second time-integrated signal proportional to the average arterial blood flow at said location; and (f) subtracting the second signal obtained in step (d) from the first signal obtained in step (b) to provide a third signal proportional to the average non-pulsatile residual arterial blood flow at said location.
Claim 21
Dependent Claim
316 words
Apparatus for pulsatizing blood flow in a limb of a living being, the apparatus comprising: a pressure cuff adapted to be wrapped around a limb of a living being at a predetermined location along the limb; a source of air at a predetermined pressure connected to the cuff; a first valve between the source of air pressure and the cuff for selectively inflating the cuff; an exhaust line connected to the cuff; a second valve in the exhaust line for selectively releasing air pressure from the cuff; sensing means adapted to be placed on the skin of the living being at a location where a strong electrocardiac signal can be obtained for use as a synchronizing and timing signal; a trigger circuit connected to the sensing means for providing a trigger pulse in synchronism with the R-wave of each heart cycle detected by the sensing means; a first duration generator coupled to the output of the trigger circuit for producing a first timing pulse for opening the first valve long enough to attain said predetermined pressure in the cuff in response to the first trigger pulse; a first valve driver connected between the output of the first duration generator and the first valve for opening the first valve for the duration of the first timing pulse; a delay generator connected to the output of the trigger circuit for delaying each trigger pulse for a predetermined time until the onset of the next ensuing systolic period; a second duration generator connected to the output of the delay generator for producing a second timing pulse for opening the second valve long enough to completely exhaust the pressure in the cuff in response to the delayed trigger pulse; and a second valve driver connected between the output of the second duration generator and the second valve for opening the second valve for the duration of the second timing pulse.
Claim 22
Dependent Claim
316 words
Apparatus for pulsatizing blood flow in a limb of a living being, the apparatus comprising: a pressure cuff adapted to be wrapped around a limb of a living being at a predetermined location along the limb; a source of air at a predetermined pressure connected to the cuff; a first valve between the source of air pressure and the cuff for selectively inflating the cuff; an exhaust line connected to the cuff; a second valve in the exhaust line for selectively releasing air pressure from the cuff; sensing means adapted to be placed on the skin of the living being at a location where a strong electrocardiac signal can be obtained for use as a synchronizing and timing signal; a trigger circuit connected to the sensing means for providing a trigger pulse in synchronism with the R-wave of each heart cycle detected by the sensing means; a first duration generator coupled to the output of the trigger circuit for producing a first timing pulse for opening the first valve long enough to attain said predetermined pressure in the cuff in response to the first trigger pulse; a first valve driver connected between the output of the first duration generator and the first valve for opening the first valve for the duration of the first timing pulse; a delay generator connected to the output of the trigger circuit for delaying each trigger pulse for a predetermined time until the onset of the next ensuing systolic period; a second duration generator connected to the output of the delay generator for producing a second timing pulse for opening the second valve long enough to completely exhaust the pressure in the cuff in response to the delayed trigger pulse; and a second valve driver connected between the output of the second duration generator and the second valve for opening the second valve for the duration of the second timing pulse.
Claim 23
Dependent Claim
352 words
Apparatus for pulsatizing blood flow in a limb of a living being, the apparatus comprising: a pressure cuff adapted to be wrapped around a limb of a living being at a predetermined location along the limb; a source of air at a predetermined pressure connected to the cuff; a first valve between the source of air pressure and the cuff for selectively inflating the cuff; an exhaust line connected to the cuff; a second valve in the exhaust line for selectively releasing air pressure from the cuff; sensing means adapted to be placed on the skin of the living being at a location where a strong electrocardiac signal can be obtained for use as a synchronizing and timing signal; a trigger circuit connected to the sensing means for providing a trigger pulse in synchronism with the R-wave of each heart cycle detected by the second sensing means; a first delay generator connected to the output of the trigger circuit for delaying each trigger pulse for a predetermined time until the onset of the next ensuing diastolic period; a first duration generator connected to the output of the first delay generator for producing a first timing pulse for opening the first valve long enough to attain said predetermined pressure in the cuff in response to the first delayed trigger pulse; a first valve driver connected between the output of the first duration generator and the first valve for opening the first valve for the duration of the first timing pulse; a second delay generator connected to the output of the trigger circuit for delaying each trigger pulse for a predetermined time until the onset of the next ensuing systolic period; a second duration generator connected to the output of the second delay generator for producing a second timing pulse for opening the second valve long enough to completely exhaust the pressure in the cuff in response to the second delayed trigger pulse; and a second valve driver connected between the output of the second duration generator and the second valve for opening the second valve for the duration of the second timing pulse.
Claim 24
Dependent Claim
352 words
Apparatus for pulsatizing blood flow in a limb of a living being, the apparatus comprising: a pressure cuff adapted to be wrapped around a limb of a living being at a predetermined location along the limb; a source of air at a predetermined pressure connected to the cuff; a first valve between the source of air pressure and the cuff for selectively inflating the cuff; an exhaust line connected to the cuff; a second valve in the exhaust line for selectively releasing air pressure from the cuff; sensing means adapted to be placed on the skin of the living being at a location where a strong electrocardiac signal can be obtained for use as a synchronizing and timing signal; a trigger circuit connected to the sensing means for providing a trigger pulse in synchronism with the R-wave of each heart cycle detected by the second sensing means; a first delay generator connected to the output of the trigger circuit for delaying each trigger pulse for a predetermined time until the onset of the next ensuing diastolic period; a first duration generator connected to the output of the first delay generator for producing a first timing pulse for opening the first valve long enough to attain said predetermined pressure in the cuff in response to the first delayed trigger pulse; a first valve driver connected between the output of the first duration generator and the first valve for opening the first valve for the duration of the first timing pulse; a second delay generator connected to the output of the trigger circuit for delaying each trigger pulse for a predetermined time until the onset of the next ensuing systolic period; a second duration generator connected to the output of the second delay generator for producing a second timing pulse for opening the second valve long enough to completely exhaust the pressure in the cuff in response to the second delayed trigger pulse; and a second valve driver connected between the output of the second duration generator and the second valve for opening the second valve for the duration of the second timing pulse.
Claim 25
Dependent Claim
451 words
Apparatus for measuring blood flow in a limb of a living being, the apparatus comprising: a pressure cuff adapted to be wrapped around a limb of a living being at a predetermined location along the limb; a source of air at a predetermined pressure connected to the cuff, the pressure being sufficient to stop the flow of blood through blood vessels in the limb for a portion of a heart cycle of the living being; a first valve between the source of air pressure and the cuff for selectively inflating the cuff; an exhaust line connected to the cuff; a second valve in the exhaust line for selectively releasing air pressure from the cuff; first sensing means adapted to be placed adjacent to said means for applying pressure at a location suitable for detecting signals in response to blood flow in said blood vessels; second sensing means adapted to be placed on the skin of the living being at a location where a strong electrocardiac signal can be obtained for use as a synchronizing and timing signal; a trigger circuit connected to the second sensing means for providing a trigger pulse in synchronism with the R-wave of each heart cycle detected by the second sensing means; a first delay generator connected to the output of the trigger circuit for delaying each trigger pulse for a predetermined time until the onset of the next ensuing diastolic period; a first duration generator connected to the output of the first delay generator for producing a first timing pulse for opening the first valve long enough to attain said predetermined pressure in the cuff in response to the first delayed trigger pulse; a first valve driver connected between the output of the first duration generator and the first valve for opening the first valve for the duration of the first timing pulse; a second delay generator connected to the output of the trigger circuit for delaying each trigger pulse for a predetermined time until the onset of the next ensuing systolic period; a second duration generator connected to the output of the second delay generator for producing a second timing pulse for opening the second valve long enough to completely exhaust the pressure in the cuff in response to the second delayed trigger pulse; a second valve driver connected between the output of the second duration generator and the second valve for opening the second valve for the duration of the second timing pulse; and means connected to the first and second sensing means for processing the signals detected by the first sensing means for a predetermined number of heart cycles as detected by the second sensing means to produce a time-averaged blood flow signal.
Claim 26
Dependent Claim
451 words
Apparatus for measuring blood flow in a limb of a living being, the apparatus comprising: a pressure cuff adapted to be wrapped around a limb of a living being at a predetermined location along the limb; a source of air at a predetermined pressure connected to the cuff, the pressure being sufficient to stop the flow of blood through blood vessels in the limb for a portion of a heart cycle of the living being; a first valve between the source of air pressure and the cuff for selectively inflating the cuff; an exhaust line connected to the cuff; a second valve in the exhaust line for selectively releasing air pressure from the cuff; first sensing means adapted to be placed adjacent to said means for applying pressure at a location suitable for detecting signals in response to blood flow in said blood vessels; second sensing means adapted to be placed on the skin of the living being at a location where a strong electrocardiac signal can be obtained for use as a synchronizing and timing signal; a trigger circuit connected to the second sensing means for providing a trigger pulse in synchronism with the R-wave of each heart cycle detected by the second sensing means; a first delay generator connected to the output of the trigger circuit for delaying each trigger pulse for a predetermined time until the onset of the next ensuing diastolic period; a first duration generator connected to the output of the first delay generator for producing a first timing pulse for opening the first valve long enough to attain said predetermined pressure in the cuff in response to the first delayed trigger pulse; a first valve driver connected between the output of the first duration generator and the first valve for opening the first valve for the duration of the first timing pulse; a second delay generator connected to the output of the trigger circuit for delaying each trigger pulse for a predetermined time until the onset of the next ensuing systolic period; a second duration generator connected to the output of the second delay generator for producing a second timing pulse for opening the second valve long enough to completely exhaust the pressure in the cuff in response to the second delayed trigger pulse; a second valve driver connected between the output of the second duration generator and the second valve for opening the second valve for the duration of the second timing pulse; and means connected to the first and second sensing means for processing the signals detected by the first sensing means for a predetermined number of heart cycles as detected by the second sensing means to produce a time-averaged blood flow signal.
Claim 27
Dependent Claim
387 words
Apparatus for measuring blood flow in a limb of a living being, the apparatus comprising: a pressure cuff adapted to be wrapped around a limb of a living being at a predetermined location along the limb; a source of air at a predetermined pressure connected to the cuff, the pressure being sufficient to stop the flow of blood through blood vessels in the limb for a portion of a heart cycle of the living being; a first valve between the source of air pressure and the cuff for selectively inflating the cuff; an exhaust line connected to the cuff; a second valve in the exhaust line for selectively releasing air pressure from the cuff; first sensing means adapted to detect blood flow in said vessels at said location; second sensing means adapted to detect an electrocardiac signal of said living being for use as a synchronizing and timing signal; a trigger circuit connected to the second sensing means for providing a trigger pulse in synchronism with the R-wave of each heart cycle detected by the second sensing means; a first duration generator coupled to the output of the trigger circuit for producing a first timing pulse for opening the first valve long enough to attain said predetermined pressure in the cuff in response to the trigger pulse; a first valve driver connected between the output of the first duration generator and the first valve for opening the first valve for the duration of the first timing pulse; a delay generator connected to the output of the trigger circuit for delaying each trigger pulse for a predetermined time until the onset of the next ensuing systolic period; a second duration generator connected to the output of the delay generator for producing a second timing pulse for opening the second valve long enough to completely exhaust the pressure in the cuff in response to the delayed trigger pulse; a second valve driver connected between the output of the second duration generator and the second valve for opening the second valve for the duration of the second timing pulse; and means connected to the first and second sensing means for processing the signals detected by the first sensing means for a predetermined number of heart cycles as detected by the second sensing means to produce a time-averaged blood flow signal.
Claim 28
Dependent Claim
387 words
Apparatus for measuring blood flow in a limb of a living being, the apparatus comprising: a pressure cuff adapted to be wrapped around a limb of a living being at a predetermined location along the limb; a source of air at a predetermined pressure connected to the cuff, the pressure being sufficient to stop the flow of blood through blood vessels in the limb for a portion of a heart cycle of the living being; a first valve between the source of air pressure and the cuff for selectively inflating the cuff; an exhaust line connected to the cuff; a second valve in the exhaust line for selectively releasing air pressure from the cuff; first sensing means adapted to detect blood flow in said vessels at said location; second sensing means adapted to detect an electrocardiac signal of said living being for use as a synchronizing and timing signal; a trigger circuit connected to the second sensing means for providing a trigger pulse in synchronism with the R-wave of each heart cycle detected by the second sensing means; a first duration generator coupled to the output of the trigger circuit for producing a first timing pulse for opening the first valve long enough to attain said predetermined pressure in the cuff in response to the trigger pulse; a first valve driver connected between the output of the first duration generator and the first valve for opening the first valve for the duration of the first timing pulse; a delay generator connected to the output of the trigger circuit for delaying each trigger pulse for a predetermined time until the onset of the next ensuing systolic period; a second duration generator connected to the output of the delay generator for producing a second timing pulse for opening the second valve long enough to completely exhaust the pressure in the cuff in response to the delayed trigger pulse; a second valve driver connected between the output of the second duration generator and the second valve for opening the second valve for the duration of the second timing pulse; and means connected to the first and second sensing means for processing the signals detected by the first sensing means for a predetermined number of heart cycles as detected by the second sensing means to produce a time-averaged blood flow signal.
References Cited (Backward Citations)
US3482565A
Cited
US3527204A
Cited
GB1185443A
Cited
US3552383A
Cited
GB1340542A
Cited
GB1426319A
Cited
US3920004A
Cited
US3847142A
Cited
US3996924A
Cited
US4030485A
Cited
US3994285A
Cited
US3996925A
Cited
US4116230A
Cited
US4134396A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-06-03 | 1983-12-03 | 1984-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-06-03 | 1987-12-03 | 1988-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-06-03 | 1991-12-03 | 1992-06-03 | $7700.00 | Window Closed / Lapsed |