US4202323A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug activation by radiation
Assignee: Individual
•
Filing: 1978-04-28
•
Granted: 1980-05-13
•
Expires: 1998-04-28
Abstract
Abstract A method of selectively causing drug activation within a living body which comprises administering to a living body a polyamino arylmethylnitrile capable of undergoing controlled cleavage to form a polyaminoaryl methyl ion and/or a free cyanide ion, the drug also being soluble in the body serum so that it is capable of passing via oral, intramuscular or intra-peritoneal administration into a body, and then subjecting a localized area of said body to radiation capable of causing cleavage of the cyanide ion from the drug precursor, the resulting ions acting to sensitize the localized area to radiation.
Inventors
- 👤 Jack Zweig
- 👤 William McLaughlin
- 👤 Matthew L. Herz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:41
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/0004; A61K49/0006; A61K31/00; A61K31/275; A61K41/00; A61K41/0042
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
100 words
A method of selectively causing drug activation in a localized area within a living body which comprises administering to said body a substituted aminotriarylacetonitrile capable of undergoing radiation induced cleavage to form a substituted aminotriarylmethyl component and a free cyanide component, said nitrile being soluble in the body serum so that it is capable of passing by the administration thereof to said body, and then subjecting a localized area to radiation capable of causing cleavage of said cyanide species from said nitrile in said localized area, said cyanide ion and/or carbocation acting as a radiation sensitizer in said localized area.
Claim 2
Independent Claim
100 words
A method of selectively causing drug activation in a localized area within a living body which comprises administering to said body a substituted aminotriarylacetonitrile capable of undergoing radiation induced cleavage to form a substituted aminotriarylmethyl component and a free cyanide component, said nitrile being soluble in the body serum so that it is capable of passing by the administration thereof to said body, and then subjecting a localized area to radiation capable of causing cleavage of said cyanide species from said nitrile in said localized area, said cyanide ion and/or carbocation acting as a radiation sensitizer in said localized area.
Claim 3
Dependent Claim
20 words
A method according to claim 1, wherein said aminotriarylacetonitrile is substituted with one or more sulfonic acid or sulfonate groups.
Claim 4
Dependent Claim
15 words
A method according to claim 1, wherein said aminotriarylacetonitrile is the disodium salt of 4-diethylaminophenyl-4',4"-bis-(3-sulfobenzylethylaminophenyl)acetonitrile.
Claim 5
Dependent Claim
12 words
A method according to claim 1, wherein the substituted aminotriarylacetonitrile is hydrophilic.
Claim 6
Dependent Claim
12 words
A method according to claim 1, wherein said radiation is gamma irradiation.
Claim 7
Dependent Claim
12 words
A method according to claim 1, wherein said radiation is x-ray irradiation.
Claim 8
Dependent Claim
12 words
A method according to claim 1, wherein said radiation is ultraviolet irradiation.
Claim 9
Dependent Claim
12 words
A method according to claim 1, wherein said localized area is neoplastic.
Claim 10
Dependent Claim
11 words
A method according to claim 1, wherein said administration is oral.
Claim 11
Dependent Claim
12 words
A method according to claim 1, wherein said administration is by injection.
Claim 12
Dependent Claim
12 words
A method according to claim 10, wherein said injection is given intra-peritoneally.
Claim 13
Dependent Claim
25 words
A method according to claim 3, wherein up to 15 mg/kilo of cyanide was administered to said body in the form of said disodium salt.
References Cited (Backward Citations)
US4106488A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-05-13 | 1983-11-12 | 1984-05-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-05-13 | 1987-11-12 | 1988-05-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-05-13 | 1991-11-12 | 1992-05-13 | $7700.00 | Window Closed / Lapsed |