US4199954A
Expired / Lapsed
US
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Method of storing physiological material
Assignee: American Red Cross
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Filing: 1978-08-09
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Granted: 1980-04-29
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Expires: 1998-08-09
Abstract
Abstract Human cells or tissue in suspension or immersion in physiological solution are stored at a basic storage temperature of about 4 DEG C., and periodically subjected to a higher temperature within the range of from 25 DEG -37 DEG C. for a period of time and at intervals sufficient to inhibit irreversible losses in function and viability of the cells or tissue. The method is particularly suitable for the storage of blood platelet concentrates in plasma to be subsequently used in transfusions, enabling prolonged storage periods with improved overall effectiveness of the transfused platelets.
Inventors
- 👤 Manley McGill
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 10:39
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/16; A01N1/162
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
98 words
In the method of storing a physiological material comprising a suspension or immersion of human cells or tissue in physiological solution at a basic storage temperature of about 4° C., the improvement consisting of a temperature cycling procedure which comprises periodically interrupting the 4° C. storage by subjecting said material to a higher temperature within the range of from 25° to 37° C. for a period of time and at intervals sufficient to inhibit the irreversible losses in function and viability of said cells or tissue which would otherwise occur with a continuous and uninterrupted 4° C. storage.
Claim 2
Dependent Claim
98 words
In the method of storing a physiological material comprising a suspension or immersion of human cells or tissue in physiological solution at a basic storage temperature of about 4° C., the improvement consisting of a temperature cycling procedure which comprises periodically interrupting the 4° C. storage by subjecting said material to a higher temperature within the range of from 25° to 37° C. for a period of time and at intervals sufficient to inhibit the irreversible losses in function and viability of said cells or tissue which would otherwise occur with a continuous and uninterrupted 4° C. storage.
Claim 3
Dependent Claim
34 words
The method of claim 1, wherein said period of time is within the range of from fifteen minutes to one hour, and said intervals are within the range of from four to twenty-four hours.
Claim 4
Dependent Claim
16 words
The method of claim 2, wherein said material is a blood cellular element concentrate in plasma.
Claim 5
Dependent Claim
15 words
The method of claim 3, wherein said material is a blood platelet concentrate in plasma.
Claim 6
Dependent Claim
34 words
The method of claim 4, wherein said blood platelet concentrate is periodically subjected to a temperature of about 37° C. for periods of about thirty minutes duration and at intervals of about twelve hours.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-29 | 1983-10-29 | 1984-04-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-29 | 1987-10-29 | 1988-04-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-29 | 1991-10-29 | 1992-04-29 | $7700.00 | Window Closed / Lapsed |