US4199592A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antiinflammatory 4,5-diaryl-2-nitroimidazoles
Assignee: EIDP Inc
•
Filing: 1979-03-06
•
Granted: 1980-04-22
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Expires: 1999-03-06
Abstract
Abstract Antiinflammatory 4,5-diaryl-2-nitroimidazoles, such as 4,5-bis(4-fluorophenyl)-2-nitroimidazole, useful for treating arthritis and related diseases.
Inventors
- 👤 Saul C. Cherkofsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 11:31
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/44; C07D213/46; C07D213/50; C07D233/66; C07D233/91; C07D333/00; C07D333/02; C07D333/04; C07D333/06; C07D333/22
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
161 words
A compound of the formula ##STR52## where R 1 and R 2 independently are ##STR53## with the proviso at least one of R 1 and R 2 must be ##STR54## Y 1 is F, Cl, N(CH 3 ) 2 or C 1 -C 4 alkoxy; Y 2 is H, F, Cl; R 3 is H, ##STR55## 2-tetrahydropyranyl, 2-tetrahydrofuranyl, ##STR56## or --SO 2 Ar; R 5 is H or methyl; R 6 is C 1 -C 3 alkyl, benzyl, --CH 2 CH 2 OCH 3 or ##STR57## R 7 is C 1 -C 4 alkyl or benzyl; and Ar is ##STR58## where Y 3 is H, F, Cl, Br, C 1 -C 4 alkyl, C 1 -C 4 alkoxy or nitro; or a pharmaceutically suitable acid addition salt thereof where at least one of R 1 and R 2 is ##STR59## where Y 1 is N(CH 3 ) 2 , or a pharmaceutically suitable metal salt thereof where R 3 is H.
Claim 2
Dependent Claim
161 words
A compound of the formula ##STR52## where R 1 and R 2 independently are ##STR53## with the proviso at least one of R 1 and R 2 must be ##STR54## Y 1 is F, Cl, N(CH 3 ) 2 or C 1 -C 4 alkoxy; Y 2 is H, F, Cl; R 3 is H, ##STR55## 2-tetrahydropyranyl, 2-tetrahydrofuranyl, ##STR56## or --SO 2 Ar; R 5 is H or methyl; R 6 is C 1 -C 3 alkyl, benzyl, --CH 2 CH 2 OCH 3 or ##STR57## R 7 is C 1 -C 4 alkyl or benzyl; and Ar is ##STR58## where Y 3 is H, F, Cl, Br, C 1 -C 4 alkyl, C 1 -C 4 alkoxy or nitro; or a pharmaceutically suitable acid addition salt thereof where at least one of R 1 and R 2 is ##STR59## where Y 1 is N(CH 3 ) 2 , or a pharmaceutically suitable metal salt thereof where R 3 is H.
Claim 3
Dependent Claim
14 words
A compound of claim 1 where R 1 and R 2 are independently ##STR60##
Claim 4
Dependent Claim
26 words
A compound of claim 1 where R 1 or R 2 is ##STR61## Y 1 is F, Cl, or OCH 3 , and Y 2 =H.
Claim 5
Dependent Claim
12 words
A compound of claim 3 where Y 1 is in the para-position.
Claim 6
Dependent Claim
10 words
A compound of claim 1 where R 3 is H.
Claim 7
Dependent Claim
13 words
A compound of claim 2 where R 1 or R 2 is ##STR62##
Claim 8
Dependent Claim
24 words
A compound of claim 4 where Y 1 is F, Cl or OCH 3 ; Y 2 is H; and R 3 is H.
Claim 9
Dependent Claim
19 words
The compound of claim 1 where R 1 and R 2 are both ##STR63## and R 3 is H.
Claim 10
Dependent Claim
19 words
The compound of claim 1 where R 1 and R 2 are both ##STR64## and R 3 is H.
Claim 11
Dependent Claim
21 words
A pharmaceutical composition consisting essentially of a suitable pharmaceutical carrier and an effective antiinflammatory amount of a compound of claim 1.
Claim 12
Dependent Claim
21 words
A pharmaceutical composition consisting essentially of a suitable pharmaceutical carrier and an effective antiinflammatory amount of a compound of claim 2.
Claim 13
Dependent Claim
21 words
A pharmaceutical composition consisting essentially of a suitable pharmaceutical carrier and an effective antiinflammatory amount of a compound of claim 3.
Claim 14
Dependent Claim
21 words
A pharmaceutical composition consisting essentially of a suitable pharmaceutical carrier and an effective antiinflammatory amount of a compound of claim 4.
Claim 15
Dependent Claim
21 words
A pharmaceutical composition consisting essentially of a suitable pharmaceutical carrier and an effective antiinflammatory amount of a compound of claim 5.
Claim 16
Dependent Claim
21 words
A pharmaceutical composition consisting essentially of a suitable pharmaceutical carrier and an effective antiinflammatory amount of a compound of claim 6.
Claim 17
Dependent Claim
21 words
A pharmaceutical composition consisting essentially of a suitable pharmaceutical carrier and an effective antiinflammatory amount of the compound of claim 7.
Claim 18
Dependent Claim
21 words
A pharmaceutical composition consisting essentially of a suitable pharmaceutical carrier and an effective antiinflammatory amount of a compound of claim 8.
Claim 19
Dependent Claim
21 words
A pharmaceutical composition consisting essentially of a suitable pharmaceutical carrier and an effective antiinflammatory amount of the compound of claim 9.
Claim 20
Dependent Claim
24 words
A method of treating arthritis in a mammal which comprises administering to the mammal an effective antiarthritic amount of a compound of claim 1.
Claim 21
Dependent Claim
24 words
A method of treating arthritis in a mammal which comprises administering to the mammal an effective antiarthritic amount of a compound of claim 2.
Claim 22
Dependent Claim
24 words
A method of treating arthritis in a mammal which comprises administering to the mammal an effective antiarthritic amount of a compound of claim 3.
Claim 23
Dependent Claim
24 words
A method of treating arthritis in a mammal which comprises administering to the mammal an effective antiarthritic amount of a compound of claim 4.
Claim 24
Dependent Claim
24 words
A method of treating arthritis in a mammal which comprises administering to the mammal an effective antiarthritic amount of a compound of claim 5.
Claim 25
Dependent Claim
24 words
A method of treating arthritis in a mammal which comprises administering to the mammal an effective antiarthritic amount of a compound of claim 6.
Claim 26
Dependent Claim
24 words
A method of treating arthritis in a mammal which comprises administering to the mammal an effective antiarthritic amount of a compound of claim 7.
Claim 27
Dependent Claim
24 words
A method of treating arthritis in a mammal which comprises administering to the mammal an effective antiarthritic amount of the compound of claim 8.
Claim 28
Dependent Claim
24 words
A method of treating arthritis in a mammal which comprises administering to the mammal an effective antiarthritic amount of the compound of claim 9.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-22 | 1983-10-22 | 1984-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-22 | 1987-10-22 | 1988-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-22 | 1991-10-22 | 1992-04-22 | $7700.00 | Window Closed / Lapsed |