US4199582A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Piperazine containing dihydronaphthalene derivatives and compositions
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1978-07-26
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Granted: 1980-04-22
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Expires: 1998-07-26
Abstract
Abstract Novel 1,2-dihydronaphthalene derivatives of the formula <IMAGE> wherein A is a di-lower alkylamino group or a 5- to 7-membered cyclic amino group which may contain one oxygen atom and n is 2 or 3, and its salts have excellent pharmacological activities such as vasodilator, hypotensive and cerebral blood flow increasing actions.
Inventors
- 👤 Yoshikazu Oka
- 👤 Katsumi Itoh
- 👤 Minoru Hirata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 03:27
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/02; C07D295/027; C07D295/03; A; A61; A61P; A61P9/00; A61P9/08; A61P9/12; C07D243/00; C07D243/06; C07D243/08; C07D295/04; C07D295/10; C07D295/112; C07D295/116; C07D295/12; C07D295/135
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
19 words
A compound of the formula ##STR19## wherein A is 1-pyrrolidinyl, piperidino or 1-homopiperidinyl or an acid addition salt thereof.
Claim 2
Dependent Claim
19 words
A compound of the formula ##STR19## wherein A is 1-pyrrolidinyl, piperidino or 1-homopiperidinyl or an acid addition salt thereof.
Claim 3
Dependent Claim
10 words
A compound according to claim 1, wherein A is piperidino.
Claim 4
Dependent Claim
13 words
A compound according to claim 1, wherein the acid addition salt is hydrochloride.
Claim 5
Dependent Claim
10 words
A compound according to claim 1, said compound being 3-[(4-benzhydryl-1-piperazinyl)methyl]-7-piperidino-1,2-dihydronaphthalene.
Claim 6
Dependent Claim
44 words
A pharmaceutical composition which comprises, as the active ingredient, a vasodilator effective amount of at least one compound of the formula ##STR20## wherein A is 1-pyrrolidinyl, piperidino or 1-homopiperidinyl or an acid addition salt thereof together with a pharmaceutically acceptable carrier, excipient or diluent.
Claim 7
Dependent Claim
44 words
A pharmaceutical composition which comprises, as the active ingredient, a vasodilator effective amount of at least one compound of the formula ##STR20## wherein A is 1-pyrrolidinyl, piperidino or 1-homopiperidinyl or an acid addition salt thereof together with a pharmaceutically acceptable carrier, excipient or diluent.
References Cited (Backward Citations)
JPS4911713A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-22 | 1983-10-22 | 1984-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-22 | 1987-10-22 | 1988-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-22 | 1991-10-22 | 1992-04-22 | $7700.00 | Window Closed / Lapsed |