US4199566A
Expired / Lapsed
US
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Antibacterial composition for medical use
Assignee: Toyama Chemical Co Ltd
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Filing: 1978-06-06
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Granted: 1980-04-22
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Expires: 1998-06-06
Abstract
Abstract An antibacterial composition for medical use comprising 6-[-)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetamido]penicillanic acid or a pharmaceutically acceptable salt thereof and a β-lactamase-inhibiting penicillin or cephalosporin. The composition exhibits synergistic effect which is much greater than the sum of antibacterial effects of each component used alone.
Inventors
- 👤 Isamu Saikawa
- 👤 Takashi Yasuda
- 👤 Masaru Tai
- 👤 Yutaka Takashita
- 👤 Hiroshi Sakai
- 👤 Michiko Mae
- 👤 Masahiro Takahata
- 👤 Susumu Mitsuhashi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 06:26
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/425; A61K31/429; A61K31/43; A61K31/54; A61K31/542; A61K31/545; A61P; A61P31/00; A61P31/04; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
63 words
An antibacterial composition for administration to a host animal, comprising: as active ingredients 6-[D(-)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetamido]-penicillanic acid represented by the formula: ##STR2## or a pharmaceutically acceptable salt thereof and a β-lactamase-inhibiting penicillin selected from the group consisting of Cloxacillin, Dicloxacillin, Oxacillin, Methicillin, Flucloxacillin and a pharmaceutically acceptable salt thereof, said β-lactamase-inhibiting penicillin being mixed with said penicillanic acid in a ratio of 0.5 to 1.5.
Claim 2
Dependent Claim
63 words
An antibacterial composition for administration to a host animal, comprising: as active ingredients 6-[D(-)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetamido]-penicillanic acid represented by the formula: ##STR2## or a pharmaceutically acceptable salt thereof and a β-lactamase-inhibiting penicillin selected from the group consisting of Cloxacillin, Dicloxacillin, Oxacillin, Methicillin, Flucloxacillin and a pharmaceutically acceptable salt thereof, said β-lactamase-inhibiting penicillin being mixed with said penicillanic acid in a ratio of 0.5 to 1.5.
Claim 3
Dependent Claim
22 words
The antibacterial composition of claim 1, wherein the pharmaceutically acceptable salt of Cloxacillin, Dicloxacillin, Oxacillin, Methicillin or Flucloxacillin is the sodium salt.
Claim 4
Dependent Claim
18 words
The antibacterial composition of claim 1, wherein the pharmaceutically acceptable salt of 6-[D(-)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetamide]penicillanic acid is the sodium salt.
Claim 5
Dependent Claim
13 words
The antibacterial composition of claim 3, wherein the β-lactamase-inhibiting penicillin is Cloxacillin sodium.
Claim 6
Dependent Claim
13 words
The antibacterial composition of claim 3, wherein the β-lactamase-inhibiting penicillin is Methicillin sodium.
Claim 7
Dependent Claim
20 words
An antibacterial composition for administration to a host animal, which comprises: the composition of claim 1 in an injectable form.
Claim 8
Dependent Claim
27 words
An antibacterial composition for administration to a host animal, comprising: the composition of claim 1 in a pharmaceutically effective amount in a diluent conventionally used in injections.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-22 | 1983-10-22 | 1984-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-22 | 1987-10-22 | 1988-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-22 | 1991-10-22 | 1992-04-22 | $7700.00 | Window Closed / Lapsed |