US4199504A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bridged cathranthus alkaloid dimers
Assignee: Eli Lilly and Co
•
Filing: 1978-05-15
•
Granted: 1980-04-22
•
Expires: 1998-05-15
Abstract
Abstract Bridged vinca dimers in which two indole-dihydro-indole C-3 carboxamides are linked through the nitrogen atom of a carboxamide group, useful as oncolytic agents.
Inventors
- 👤 Robert A. Conrad
- 👤 Koert Gerzon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:21
CPC Classifications
C; C07; C07D; C07D519/00; C07D519/04; A; A61; A61P; A61P35/00; A61P35/02
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
106 words
A compound of the formula R--NH--CH.sub.2 --(CH.sub.2).sub.n --X--(CH.sub.2).sub.n --CH.sub.2 --NH--R wherein each R is ##STR3## wherein R 1 is OH or O--CO--CH 3 ; R 2 is CH 3 , H or CHO; when taken singly, one of R 3 and R 4 is H or OH, the other being C 2 H 5 , and R 5 is H; and when R 4 and R 5 are taken together, they form an α-epoxide ring and R 3 is C 2 H 5 ; X is S, O, Se--Se, or a bond wherein each n is 0, 1, or 2; and pharmaceutically-acceptable acid addition salts thereof.
Claim 2
Dependent Claim
106 words
A compound of the formula R--NH--CH.sub.2 --(CH.sub.2).sub.n --X--(CH.sub.2).sub.n --CH.sub.2 --NH--R wherein each R is ##STR3## wherein R 1 is OH or O--CO--CH 3 ; R 2 is CH 3 , H or CHO; when taken singly, one of R 3 and R 4 is H or OH, the other being C 2 H 5 , and R 5 is H; and when R 4 and R 5 are taken together, they form an α-epoxide ring and R 3 is C 2 H 5 ; X is S, O, Se--Se, or a bond wherein each n is 0, 1, or 2; and pharmaceutically-acceptable acid addition salts thereof.
Claim 3
Dependent Claim
13 words
A compound according to claim 1, said compound being bis[β-(4-desacetyl VLB C-3 carboxamido)ethyl]diselenide.
Claim 4
Dependent Claim
13 words
A compound according to claim 1, said compound being bis[β-(4-desacetyl VLB C-3 carboxamido)ethyl]ether.
Claim 5
Dependent Claim
13 words
A compound according to claim 1, said compound being 1,6-bis(4-desacetyl VLB C-3 carboxamido)hexane.
Claim 6
Dependent Claim
13 words
A compound according to claim 1, said compound being 1,4-bis(4-desacetyl VLB C-3 carboxamido)butane.
Claim 7
Dependent Claim
13 words
A compound according to claim 1, said compound being bis[β-(4-desacetyl VLB C-3 carboxamido)ethyl]sulfide.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-22 | 1983-10-22 | 1984-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-22 | 1987-10-22 | 1988-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-22 | 1991-10-22 | 1992-04-22 | $7700.00 | Window Closed / Lapsed |