US4199498A
Expired / Lapsed
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Macromolecularized adenine derivatives
Assignee: Anic SpA
•
Filing: 1978-02-22
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Granted: 1980-04-22
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Expires: 1998-02-22
Abstract
Abstract A method is disclosed for preparing functionalized adenine derivatives, said method comprising the step of reacting a compound which contains an adenine nucleus which has been halogen substituted in the 8-position, with a compound having the general formula N +- S--(CH 2 ) n --CO0 - M + wherein M + is the ion of an alkali metal and n is an integer, the reaction being carried out in a polar aprotic solvent. Procedures for preparing macromolecularized adenine compounds are also indicated by reacting a functionalized adenine derivative with a polymer which has at least one primary or secondary aminic group in its structure.
Inventors
- 👤 Piergiorgio Zappelli
- 👤 Antonio Rossodivita
- 👤 Rosario Pappa
- 👤 Luciano Re
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 16:49
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/26; C07D473/32; C07D473/34
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
82 words
Macromolecularized adenine derivatives having the general formula: ##STR12## wherein the radical ##STR13## is derived from a compound selected from the group consisting of nicotinoylamide-adenine dinucleotide, nicotinoylamide-adenine dinucleotide phosphate, adenosine monophosphate, cyclic adenosine monophosphate, adenosine triphosphate, adenosine and adenine, and the nitrogen atom bound to the CO group is part of a compound selected from the group consisting of polylysine, omega-aminoalkyl polyanilamides, polysaccharide esters of omega-aminoalkyl carbamic acids, polyvinylamine, omega-aminoalkyl esters and omega-aminoalkyl amides of polyglutamic acid, aminoalkyl silanized glass microspheres, and polyethyleneimine.
Claim 2
Dependent Claim
82 words
Macromolecularized adenine derivatives having the general formula: ##STR12## wherein the radical ##STR13## is derived from a compound selected from the group consisting of nicotinoylamide-adenine dinucleotide, nicotinoylamide-adenine dinucleotide phosphate, adenosine monophosphate, cyclic adenosine monophosphate, adenosine triphosphate, adenosine and adenine, and the nitrogen atom bound to the CO group is part of a compound selected from the group consisting of polylysine, omega-aminoalkyl polyanilamides, polysaccharide esters of omega-aminoalkyl carbamic acids, polyvinylamine, omega-aminoalkyl esters and omega-aminoalkyl amides of polyglutamic acid, aminoalkyl silanized glass microspheres, and polyethyleneimine.
Claim 3
Dependent Claim
2 words
Nicotinoylamide-8-(polyethyleneimine-3-carbonylethylthio)adenine dinucleotide.
Claim 4
Dependent Claim
2 words
Nicotinoylamide-8-(polyethyleneimine-3-carbonylethylthio)adenine dinucleotide.
Claim 5
Dependent Claim
2 words
Nicotinoylamide-8-(polylysine-2-carbonylethylthio)adenine dinucleotide.
Claim 6
Dependent Claim
2 words
Nicotinoylamide-8-(polylysine-2-carbonylethylthio)adenine dinucleotide.
Claim 7
Dependent Claim
2 words
Nicotinoylamide-8-(aminohexyl-sepharose-2-carbonylethylthio)adenine dinucleotide.
Claim 8
Dependent Claim
2 words
Nicotinoylamide-8-(aminohexyl-sepharose-2-carbonylethylthio)adenine dinucleotide.
Claim 9
Dependent Claim
3 words
Nicotinoylamide-8-(polyethyleneimine-2-carbonylethylthio)adenine dinucleotide phosphate.
Claim 10
Dependent Claim
3 words
Nicotinoylamide-8-(polyethyleneimine-2-carbonylethylthio)adenine dinucleotide phosphate.
References Cited (Backward Citations)
US4088639A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-22 | 1983-10-22 | 1984-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-22 | 1987-10-22 | 1988-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-22 | 1991-10-22 | 1992-04-22 | $7700.00 | Window Closed / Lapsed |