US4196122A
Expired / Lapsed
US
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Analgesic polypeptide
Assignee: Wyeth LLC
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Filing: 1977-07-01
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Granted: 1980-04-01
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Expires: 1997-07-01
Abstract
Abstract The polypeptides of the formula: ##STR1## in which X is hydrogen, Arg, Lys or Orn; X 5 is a D-α-amino acid; R is hydrogen, methyl, allyl or cyclopropylmethyl; and R 2 is --OH, --NH 2 or --NHC n H 2n+1 where n is 1, 2, 3 or 4 or a pharmaceutically acceptable salt thereof, exert an analgesic effect in warm-blooded animals when peripherally administered.
Inventors
- 👤 Dimitrios Sarantakis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 02:05
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/665; C07K14/70; C07K14/702; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
69 words
A polypeptide of the formula: ##STR3## in which X is hyrdogen, Arg, Lys or Orn; X 5 is D-Lys, D-Arg, D-Met or D-Leu; R is hydrogen, methyl, allyl or cyclopropylmethyl; and R 2 is --OH, NH 2 or --NHC n H 2n+1 , where n is 1,2,3 or 4 providing that when X is hyrogen then X 5 cannot be D-Met or D-Leu; or a pharmaceutically exceptable salt thereof.
Claim 2
Dependent Claim
69 words
A polypeptide of the formula: ##STR3## in which X is hyrdogen, Arg, Lys or Orn; X 5 is D-Lys, D-Arg, D-Met or D-Leu; R is hydrogen, methyl, allyl or cyclopropylmethyl; and R 2 is --OH, NH 2 or --NHC n H 2n+1 , where n is 1,2,3 or 4 providing that when X is hyrogen then X 5 cannot be D-Met or D-Leu; or a pharmaceutically exceptable salt thereof.
Claim 3
Dependent Claim
15 words
The compound of claim 1 which is Tyr-D-Pgl-Gly-Phe-D-Lys-NH 2 or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
15 words
The compound of claim 1 which is Tyr-D-Pgl-Gly-Phe-D-Arg-NH 2 or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
15 words
The compound of claim 1 which is Arg-Tyr-D-Pgl-Gly-Phe-D-Leu-NH 2 or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
15 words
The compound of claim 1 which is Orn-Tyr-D-Pgl-Gly-Phe-D-Leu-NH 2 or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
14 words
The compound of claim 1 which is Tyr-D-Pgl-Gly-Phe-D-Lys-OH or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
17 words
The compound of claim 1 which is Tyr-D-Pgl-Gly-Phe-D-Lys-NHC 2 H 5 or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
15 words
The compound of claim 1 which is Lys-N-methyl-Tyr-D-Pgl-Gly-Phe-D-Lys-NH 2 or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-01 | 1983-10-01 | 1984-04-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-01 | 1987-10-01 | 1988-04-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-01 | 1991-10-01 | 1992-04-01 | $7700.00 | Window Closed / Lapsed |