US4195088A
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1,3-Dihydro-imidazo-(4,5-b)-pyridin-2-ones
Assignee: Sanofi Aventis France
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Filing: 1978-12-26
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Granted: 1980-03-25
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Expires: 1998-12-26
Abstract
Abstract Novel 1,3-dihydro-imidazo-(4,5-b)-pyridin-2-ones of the formula ##STR1## wherein R is alkyl of 1 to 3 carbon atoms and R' is pyridyl and Y is selected from the group consisting of hydrogen and chlorine and their non-toxic, pharmaceutically acceptable acid addition salts having gastric anti-secretic and anti-ulcerogenic and anorexigenic activity and a novel process and novel intermediates for their preparation.
Inventors
- 👤 Fernando Barzaghi
- 👤 Mario Bianchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 00:21
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/72; C07D213/74; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
45 words
A compound selected from the group consisting of the formula ##STR12## wherein R is alkyl of 1 to 3 carbon atoms and R' is pyridyl and Y is selected from the group consisting of hydrogen and chlorine and their non-toxic, pharmaceutically acceptable acid addition salts.
Claim 2
Dependent Claim
45 words
A compound selected from the group consisting of the formula ##STR12## wherein R is alkyl of 1 to 3 carbon atoms and R' is pyridyl and Y is selected from the group consisting of hydrogen and chlorine and their non-toxic, pharmaceutically acceptable acid addition salts.
Claim 3
Dependent Claim
9 words
A compound of claim 1 wherein R is methyl.
Claim 4
Dependent Claim
22 words
A compound of claim 1 which is selected from the group consisting of 1-methyl-3-(4-pyridyl)-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 5
Dependent Claim
22 words
A compound of claim 1 which is selected from the group consisting of 1-methyl-3-(3-pyridyl)-5-chloro-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 6
Dependent Claim
22 words
A compound of claim 1 which is selected from the group consisting of 1-methyl-3-(2-pyridyl)-5-chloro-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 7
Dependent Claim
43 words
A compound selected from the group consisting of 2-(4-pyridylamino)-3-amino-pyridine, 2-(2-pyridylamino)-3-amino-pyridine and 2(2-pyridylamino)-3-nitro-pyridine and compounds of the formula ##STR13## wherein R' is a pyridyl and Y is selected from the group consisting of chlorine and hydrogen and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 8
Dependent Claim
43 words
A compound selected from the group consisting of 2-(4-pyridylamino)-3-amino-pyridine, 2-(2-pyridylamino)-3-amino-pyridine and 2(2-pyridylamino)-3-nitro-pyridine and compounds of the formula ##STR13## wherein R' is a pyridyl and Y is selected from the group consisting of chlorine and hydrogen and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 9
Dependent Claim
25 words
An antiulcerogenic and antisecretic composition comprising an antiulcerogically and antisecretically effective amount of at least one compound of claim 1 and an inert pharmaceutical carrier.
Claim 10
Dependent Claim
9 words
A composition of claim 7 wherein R is methyl.
Claim 11
Dependent Claim
24 words
A composition of claim 7 wherein the compound is selected from the group consisting of 1-methyl-3-(4-pyridyl)-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 12
Dependent Claim
24 words
A composition of claim 7 wherein the compound is selected from the group consisting of 1-methyl-3-(3-pyridyl)-5-chloro-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 13
Dependent Claim
24 words
A composition of claim 7 wherein the compound is selected from the group consisting of 1methyl-3-(2pyridyl)-5-chloro-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 14
Dependent Claim
32 words
A method of inducing gastric anti-secretic and antiulcerogenic activity in warm-blooded animals comprising administering to warm-blooded animals a gastric antisecretically and anti-ulcerogenically effective amount of at least one compound of claim 1.
Claim 15
Dependent Claim
9 words
A method of claim 12 wherein R is methyl.
Claim 16
Dependent Claim
24 words
A method of claim 12 wherein the compound is selected from the group consisting of 1-methyl-3-(4-pyridyl)-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 17
Dependent Claim
24 words
A method of claim 12 wherein the compound is selected from the group consisting of 1-methyl-3-(3-pyridyl)-5-chloro-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 18
Dependent Claim
24 words
A method of claim 12 wherein the compound is selected from the group consisting of 1-methyl-3-(2-pyridyl)-5-chloro-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 19
Dependent Claim
23 words
A method of inducing anorexigenic activity in warm-blooded animals comprising administering to warm-blooded animals an anorexigenically effective amount of compound of claim 1.
Claim 20
Dependent Claim
9 words
A method of claim 17 wherein R is methyl.
Claim 21
Dependent Claim
24 words
A method of claim 17 wherein the compound is selected from the group consisting of 1-methyl-3-(4-pyridyl)-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 22
Dependent Claim
24 words
A method of claim 17 wherein the compound is selected from the group consisting of 1-methyl-3-(3-pyridyl)-5-chloro-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 23
Dependent Claim
24 words
A method of claim 17 wherein the compound is selected from the group consisting of 1-methyl-3-(2-pyridyl)-5-chloro-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 24
Dependent Claim
20 words
An anorexigenic composition comprising an anorexigenically effective amount of at least one compound of claim 1 and a pharmaceutical carrier.
Claim 25
Dependent Claim
9 words
A composition of claim 22 wherein R is methyl.
Claim 26
Dependent Claim
24 words
A composition of claim 22 wherein the compound is selected from the group consisting of 1-methyl-3-(4-pyridyl)-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
Claim 27
Dependent Claim
24 words
A composition of claim 22 wherein the compound is selected from the group consisting of 1-methyl-3-(3-pyridyl)-5-chloro-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid additions salts.
Claim 28
Dependent Claim
24 words
A composition of claim 22 wherein the compound is selected from the group consisting of 1-methyl-3-(2-pyridyl)-5-chloro-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one and its non-toxic, pharmaceutically acceptable acid addition salts.
References Cited (Backward Citations)
US3401030A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-25 | 1983-09-24 | 1984-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-25 | 1987-09-24 | 1988-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-25 | 1991-09-24 | 1992-03-25 | $7700.00 | Window Closed / Lapsed |