US4195022A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4-Desacetoxy-4α-hydroxyvinblastine and related compounds
Assignee: Eli Lilly and Co
•
Filing: 1978-03-27
•
Granted: 1980-03-25
•
Expires: 1998-03-27
Abstract
Abstract 4-Desacetoxy-4 alpha -hydroxyvinblastine, prepared by reduction of 4-desacetoxy-4-oxovinblastine, and derivatives thereof, useful as antimitotic agents.
Inventors
- 👤 Gerald L. Thompson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 13:24
CPC Classifications
C; C07; C07D; C07D519/00; C07D519/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
101 words
An indole-dihydroindole of the formula ##STR4## wherein R is OCH 3 or NH--NH 2 , R 1 is H or acetyl, R 2 is CH 3 or CHO, and, when taken singly, R 5 is H and one of R 3 and R 4 is OH or H and the other is C 2 H 5 and when R 4 and R 5 are taken together, they form an α-epoxide ring and R 3 is C 2 H 5 , with the proviso that, when R is NH--NH 2 , R 1 is H, and pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
101 words
An indole-dihydroindole of the formula ##STR4## wherein R is OCH 3 or NH--NH 2 , R 1 is H or acetyl, R 2 is CH 3 or CHO, and, when taken singly, R 5 is H and one of R 3 and R 4 is OH or H and the other is C 2 H 5 and when R 4 and R 5 are taken together, they form an α-epoxide ring and R 3 is C 2 H 5 , with the proviso that, when R is NH--NH 2 , R 1 is H, and pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
43 words
A compound according to claim 1 in which R is OCH 3 , R 1 is H, R 2 is CH 3 , R 3 is OH, R 4 is C 2 H 5 and R 5 is H, said compound being 4-desacetoxy-4α-hydroxyvinblastine.
Claim 4
Dependent Claim
41 words
A compound according to claim 1 in which R is OCH 3 , R 1 is H, R 2 is CHO, R 3 is OH, R 4 is C 2 H 5 and R 5 is H, said compound being 4-desacetoxy-4α-hydroxyvincristine.
Claim 5
Dependent Claim
9 words
The sulfate salt of the compound of claim 3.
Claim 6
Dependent Claim
45 words
A compound according to claim 1 in which R is NH-NH 2 , R 1 is H, R 2 is CH 3 , R 3 is OH, R 4 is C 2 H 5 and R 5 is H, said compound being 4-desacetoxy-4α-hydroxyvinblastine C-3 carboxhydrazide.
Claim 7
Dependent Claim
10 words
A sulfate salt of a compound according to claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-25 | 1983-09-24 | 1984-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-25 | 1987-09-24 | 1988-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-25 | 1991-09-24 | 1992-03-25 | $7700.00 | Window Closed / Lapsed |