US4192953A
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Polyprenyl derivatives
Assignee: Sankyo Co Ltd
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Filing: 1979-01-04
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Granted: 1980-03-11
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Expires: 1999-01-04
Abstract
Abstract Polyprenyl derivatives having the formula ##STR1## in which R 1 and R 2 may be the same or different and each represents hydrogen atom, hydroxyl group, an alkoxy group having 1-8 carbon atoms, an aliphatic acyloxy group having 2-18 carbon atoms, an aromatic acyloxy group or an araliphatic acyloxy group having 2-3 carbon atoms in the aliphatic acyl moiety, R 3 represents hydrogen atom, an alkyl group having 1-8 carbon atoms, an aliphatic acyl group having 2-18 carbon atoms, an aromatic acyl group or an araliphatic acyl group having 2-3 carbon atoms in the aliphatic acyl moiety, n is an integer of 1-4 and, when n is an interger of 2-4, R 2 's may be the same or different; provided that, when n is 1 or 2, at least one of R 2 and R 2 's is hydroxyl group, an alkoxy group, an aliphatic acyloxy group, an aromatic acyloxy group or an araliphatic acyloxy group. These derivatives are useful as medicines for treating peptic ulcer.
Inventors
- 👤 Hiroshi Mishima
- 👤 Akira Ogiso
- 👤 Shinsaku Kobayashi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 23:12
CPC Classifications
C; C07; C07C; C07C41/00; C07C41/01; C07C41/16; C07C33/00; C07C33/02; C07C43/00; C07C43/02; C07C43/03; C07C43/14; C07C43/15; C07C45/00; C07C45/61; C07C45/67; C07C45/68; C07C69/00; C07C69/007; C07C69/02; C07C69/12; C07C69/16; C07C69/22; C07C69/28; C07C69/52; C07C69/533; C07C69/56; C07C69/612; C07C69/618; C07C69/76; C07C69/78
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
128 words
A compound having the formula ##STR20## in which R 1 and R 2 may be the same or different and each represents a hydrogen atom, hydroxyl, alkoxy having from 1 to 8 carbon atoms, aliphatic acyloxy having from 2 to 18 carbon atoms, aromatic acyloxy or araliphatic acyloxy having from 2 to 3 carbon atoms in the aliphatic acyl moiety, R 3 represents alkyl having from 1 to 8 carbon atoms, n is an integer of from 1 to 4 and, when n is an integer of from 2 to 4, the R 2 's may be the same or different; provided that, when n is 1 or 2, at least one of R 1 and R 2 is hydroxyl, alkoxy, aliphatic acyloxy, aromatic acyloxy or araliphatic acyloxy.
Claim 2
Dependent Claim
128 words
A compound having the formula ##STR20## in which R 1 and R 2 may be the same or different and each represents a hydrogen atom, hydroxyl, alkoxy having from 1 to 8 carbon atoms, aliphatic acyloxy having from 2 to 18 carbon atoms, aromatic acyloxy or araliphatic acyloxy having from 2 to 3 carbon atoms in the aliphatic acyl moiety, R 3 represents alkyl having from 1 to 8 carbon atoms, n is an integer of from 1 to 4 and, when n is an integer of from 2 to 4, the R 2 's may be the same or different; provided that, when n is 1 or 2, at least one of R 1 and R 2 is hydroxyl, alkoxy, aliphatic acyloxy, aromatic acyloxy or araliphatic acyloxy.
Claim 3
Dependent Claim
107 words
A compound according to claim 1 wherein R 1 and R 2 may be the same or different and each represents a hydrogen atom, hydroxyl, alkoxy having from 1 to 4 carbon atoms, aliphatic acyloxy having from 2 to 12 carbon atoms, benzoyloxy or cinnamoyloxy, R 3 represents alkyl having from 1 to 4 carbon atoms, n is an integer of from 1 to 3 and, when n is 2 or 3, the R 2 's may be the same or different; provided that, when n is 1 or 2, at least one of R 1 and R 2 is hydroxyl, alkoxy, aliphatic acyloxy, benzoyl or cinnamoyloxy.
Claim 4
Dependent Claim
96 words
A compound according to claim 1 wherein R 1 represents a hydrogen atom, R 2 represents a hydrogen atom, hydroxy, alkoxy having from 1 to 4 carbon atoms, aliphatic acyloxy having from 2 to 12 carbon atoms, benzoyloxy or cinnamoyloxy, R 3 represents alkyl having from 1 to 4 carbon atoms, and n is an integer of from 1 to 3; provided that, when n is 1, R 2 is other than a hydrogen atom and, when n is 2 or 3, at least one of the R 2 's is other than a hydrogen atom.
Claim 5
Dependent Claim
70 words
A compound according to claim 1 wherein R 1 represents a hydrogen atom, the R 2 in the side chain at the 7-position of the structural formula represents hydroxyl, alkoxy having from 1 to 2 carbon atoms, aliphatic acyloxy having from 2 to 12 carbon atoms, benzoyloxy or cinnamoyloxy, R 3 represents alkyl having from 1 to 2 carbon atoms, and n is an integer of from 1 to 3.
Claim 6
Dependent Claim
9 words
7-Hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol dimethyl ether of the formula of claim 1.
Claim 7
Dependent Claim
9 words
(E,Z,E)-7-Hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol dimethyl ether of the formula of claim 1.
References Cited (Backward Citations)
US3665040A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-11 | 1983-09-10 | 1984-03-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-11 | 1987-09-10 | 1988-03-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-11 | 1991-09-10 | 1992-03-11 | $7700.00 | Window Closed / Lapsed |