US4191776A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biphenyl derivatives
Assignee: Boehringer Ingelheim GmbH
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Filing: 1977-11-18
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Granted: 1980-03-04
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Expires: 1997-11-18
Abstract
Abstract Compounds of the formula <IMAGE> wherein R1 is hydrogen, fluorine, chlorine, bromine, methyl, methoxy, methylthio or cyano; R2is hydrogen or fluorine; R3 is carboxyl, (alkoxy of 1 to 6 carbon atoms)-carbonyl, methoxy-(alkoxy of 1 to 6 carbon atoms)-carbonyl, (alkenyloxy of 2 to 6 carbon atoms)-carbonyl, (aralkoxy of 7 to 12 carbon atoms)-carbonyl, phenoxy-carbonyl or pyridyl-methoxy-carbonyl, A is (alkyl of 1 to 3 carbon atoms)-methylene, m is 1 or 2; and n is 0, 1, 2 or 3; and, when R3 is carboxyl, non-toxic salts thereof formed with an inorganic or organic base. The compounds as well as the salts are useful as antithrombotics, anticholesteremics and anticoagulants.
Inventors
- 👤 Josef Nickl
- 👤 Erich Muller
- 👤 Berthold Narr
- 👤 Walter Haarmann
- 👤 Wolfgang Schroter
- 👤 Rudolf Kadatz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 07:15
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/28; C07D213/30; C07C; C07C317/00; C07C317/02; C07C317/10; C07C317/16; C07C317/18; C07C317/24; C07C317/44; C07C323/00; C07C323/10; C07C323/11; C07C323/16; C07C323/23; C07C323/45; C07C323/50; C07C323/51; C07C323/52; C07C323/60; C07C323/64; C07C323/65; C07D295/00; C07D295/16; C07D295/18; C07D295/182; C07D295/185
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
24 words
A diastereoisomer or optically active antipode of a compound of the formula ##STR5## wherein R 3 is (alkoxy of 1 to 6 carbon atoms)-carbonyl.
Claim 2
Dependent Claim
24 words
A diastereoisomer or optically active antipode of a compound of the formula ##STR5## wherein R 3 is (alkoxy of 1 to 6 carbon atoms)-carbonyl.
Claim 3
Dependent Claim
18 words
A compound of claim 1, which is methyl [1-(2'-fluoro-4-biphenylyl)-ethylsulfinyl]-acetate, a diastereoisomer thereof or an optically active antipode thereof.
Claim 4
Dependent Claim
18 words
A compound of claim 1, which is isoamyl [1-(2'-fluoro-4-biphenylyl)-ethylsulfinyl]-acetate, a diastereoisomer thereof or an optically active antipode thereof.
Claim 5
Dependent Claim
22 words
An antithrombotic pharmaceutical composition consisting essentially of an inert pharmaceutical carrier and an effective antithrombotic amount of a compound of claim 1.
Claim 6
Dependent Claim
32 words
The method of preventing or alleviating thrombosis in a warm-blooded animal in need of such treatment, which comprises administering to said animal an effective antithrombotic amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-04 | 1983-09-03 | 1984-03-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-04 | 1987-09-03 | 1988-03-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-04 | 1991-09-03 | 1992-03-04 | $7700.00 | Window Closed / Lapsed |