US4191668A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Induction of immunological tolerance
Assignee: Scripps Research Institute
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Filing: 1977-02-03
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Granted: 1980-03-04
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Expires: 1997-02-03
Abstract
Abstract Immunosuppressive agents which are conjugates of an antigen linked to a D-glutamic acid:D-lysine copolymer are disclosed. Also disclosed are methods of preparing the conjugates and therapeutic methods for inducing immunological tolerance to antigens.
Inventors
- 👤 David H. Katz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 16:44
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/35; A61K39/0005; A61K39/0008; A61K39/36; A61P; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61K2039/555; A61K2039/55511; A61K2039/55516; A61K2039/55555; A61K2039/60; A61K2039/6093; A61K38/00; Y; Y10; Y10S; Y10S524/00; Y10S524/90; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
29 words
A therapeutic immunosuppressive agent capable of inducing specific immunological tolerance to an antigen by supression of antibody response, comprising a conjugate of D-glutamic acid:D-lysine copolymer and the antigen insulin.
Claim 2
Dependent Claim
29 words
A therapeutic immunosuppressive agent capable of inducing specific immunological tolerance to an antigen by supression of antibody response, comprising a conjugate of D-glutamic acid:D-lysine copolymer and the antigen insulin.
Claim 3
Dependent Claim
30 words
An immunosuppressive agent as claimed in claim 1 wherein said copolymer has a molecular weight of from about 34,000 to 64,000 and a glutamic acid-lysine molar ratio of about 60:40.
Claim 4
Independent Claim
57 words
A method of preparing a therapeutic immunosuppressive agent comprising a conjugate of D-glutamic acid:D-lysine copolymer and an antigen which is an allergen or a self-antigen, comprising the steps of reacting D-glutamic acid:D-lysine copolymer, having an average molecular weight of from about 34,000 to 64,000 and a glutamic acid:lysine molar ratio of about 60:40, with the antigen insulin.
Claim 5
Independent Claim
57 words
A method of preparing a therapeutic immunosuppressive agent comprising a conjugate of D-glutamic acid:D-lysine copolymer and an antigen which is an allergen or a self-antigen, comprising the steps of reacting D-glutamic acid:D-lysine copolymer, having an average molecular weight of from about 34,000 to 64,000 and a glutamic acid:lysine molar ratio of about 60:40, with the antigen insulin.
Claim 6
Dependent Claim
19 words
The method as claimed in claim 3 wherein the reaction mixture is maintained at a pH of about 10-12.
References Cited (Backward Citations)
US3794630A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-04 | 1983-09-03 | 1984-03-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-04 | 1987-09-03 | 1988-03-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-04 | 1991-09-03 | 1992-03-04 | $7700.00 | Window Closed / Lapsed |