US4190716A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymeric agent for releasing 5-aminosalicylic acid or its salts into the gastrointestinal tract
Assignee: Dynapol Shareholders Liquidating Trust
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Filing: 1978-12-20
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Granted: 1980-02-26
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Expires: 1998-12-20
Abstract
Abstract A generic polymeric agent for releasing 5-aminosalicylic acid or its salts is disclosed which comprises a nonabsorbable pharmacologically acceptable organic polymer backbone containing aromatic rings to which are covalently bonded via azo bonds a plurality of salicylic acid or salicylate salt groups. The azo bonds attach to the salicylates' 5-position carbon. The polymers undergo bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid and/or its salts.
Inventors
- 👤 Thomas M. Parkinson
- 👤 Joseph P. Brown
- 👤 Robert E. Wingard, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 02:04
CPC Classifications
C; C08; C08F; C08F8/00; C08F8/34; A; A61; A61K; A61K31/00; A61K31/74; A61K31/785; A61K31/795; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/59; A61P; A61P1/00; C08F8/30; C08G; C08G65/00; C08G65/02; C08G65/32; C08G65/329; C08G65/334; C08G65/34; C08G65/48; C08G85/00; C08G85/004; Y; Y10; Y10S; Y10S260/00; Y10S260/47
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
63 words
A polymeric compound which comprises a pharmacologically acceptable organic polymer backbone comprising a plurality of aromatic rings and having a molecular size which precludes the backbone's absorption from the intestinal lumen and a plurality of salicylic acid or salicylate salt groups covalently bonded to said backbone via azo groups that are intermediate backbone aromatic carbons and salicylic acid or salicylate salt 5-position carbons.
Claim 2
Dependent Claim
63 words
A polymeric compound which comprises a pharmacologically acceptable organic polymer backbone comprising a plurality of aromatic rings and having a molecular size which precludes the backbone's absorption from the intestinal lumen and a plurality of salicylic acid or salicylate salt groups covalently bonded to said backbone via azo groups that are intermediate backbone aromatic carbons and salicylic acid or salicylate salt 5-position carbons.
Claim 3
Dependent Claim
20 words
The compound of claim 1 wherein said backbone has an average molecular weight which is not less than 1000 daltons.
Claim 4
Dependent Claim
26 words
The compound of claim 1 wherein said plurality of aromatic rings is 10 or greater and said plurality of salicylic acid groups is 5 or greater.
Claim 5
Dependent Claim
23 words
The compound of claim 3 wherein said aromatic rings are pendant from an organic chain which links them together into the polymer backbone.
Claim 6
Dependent Claim
20 words
The compound of claim 3 wherein said aromatic rings are present as integral structural units in the organic backbone chain.
Claim 7
Dependent Claim
30 words
The compound of claim 3 wherein said backbone is polystyrene and said compound comprises recurring structural units of the formula ##STR51## wherein M is hydrogen or a pharmacologically acceptable cation.
Claim 8
Dependent Claim
21 words
The compound of claim 3 having recurring units of the structure ##STR52## wherein M is hydrogen or a pharmacologically acceptable cation.
Claim 9
Dependent Claim
15 words
The compound of claim 7 wherein M is selected from among hydrogen, potassium and sodium.
Claim 10
Dependent Claim
30 words
The compound of claim 3 having recurring units of the structure ##STR53## wherein X is an amine group present in poly(ethyleneimine) and M is hydrogen or a pharmacologically acceptable cation.
Claim 11
Dependent Claim
15 words
The compound of claim 9 wherein M is selected from among hydrogen, sodium and potassium.
References Cited (Backward Citations)
US3484390A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-02-25 | 1983-08-27 | 1984-02-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-02-25 | 1987-08-27 | 1988-02-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-02-25 | 1991-08-27 | 1992-02-26 | $7700.00 | Window Closed / Lapsed |