US4190575A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polypeptides related to somatostatin
Assignee: Wyeth LLC
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Filing: 1977-12-27
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Granted: 1980-02-26
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Expires: 1997-12-27
Abstract
Abstract Compounds of the formula: ##STR1## wherein: X is H, Ala-Gly, Gly-Gly-Gly, Ala-D-Ala, acetyl, or benzoyl; X 1 is Arg or His; X 2 is Glu or Asp; X 3 is Trp or D-Trp; or 6-F-D-Trp; and X 4 is Cys- or D-Cys; or a non-toxic pharmaceutically acceptable acid addition salt thereof; inhibit the secretion of growth hormone and glucagon without materially affecting the secretion of insulin.
Inventors
- 👤 Dimitrios Sarantakis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 08:52
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/655; C07K14/6555; C07K5/00; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/16
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
58 words
A compound of the formula: ##STR6## wherein: X is H, Ala-Gly, Gly-Gly-Gly, Ala-D-Ala, acetyl, or benzoyl; X 1 is Arg or His; X 2 is Glu or Asp; X 3 is Trp or D-Trp; or 6-F-D-Trp; and X 4 is Cys or D-Cys; or the reduced linear form thereof, or a non-toxic pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
58 words
A compound of the formula: ##STR6## wherein: X is H, Ala-Gly, Gly-Gly-Gly, Ala-D-Ala, acetyl, or benzoyl; X 1 is Arg or His; X 2 is Glu or Asp; X 3 is Trp or D-Trp; or 6-F-D-Trp; and X 4 is Cys or D-Cys; or the reduced linear form thereof, or a non-toxic pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
13 words
A compound as defined in claim 1 which is L-cysteinyl-L-arginyl-L-glutamyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (1-12) disulfide.
Claim 4
Dependent Claim
10 words
A compound as defined in claim 1 which is L-cysteinyl-L-arginyl-L-glutamyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine.
Claim 5
Dependent Claim
13 words
A compound as defined in claim 1 which is L-cysteinyl-L-histidyl-L-glutamyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (1-12) disulfide.
Claim 6
Dependent Claim
10 words
A compound as defined in claim 1 which is L-cysteinyl-L-histidyl-L-glutamyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine.
References Cited (Backward Citations)
BE839405A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-02-25 | 1983-08-27 | 1984-02-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-02-25 | 1987-08-27 | 1988-02-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-02-25 | 1991-08-27 | 1992-02-26 | $7700.00 | Window Closed / Lapsed |