US4187307A
Expired / Lapsed
US
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Diuretics
Assignee: Abbott Laboratories
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Filing: 1978-10-16
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Granted: 1980-02-05
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Expires: 1998-10-16
Abstract
Abstract Specific 4-amino pteridines carrying particular phenyl substituents in the 7-position and no substituents in the 2-position have been found to be excellent nonkaliuretic diuretics at doses of 30 to 500 mg/kg in warm-blooded animals.
Inventors
- 👤 Gerard Y. Paris
- 👤 Denis G. Cimon
- 👤 Dilbagh S. Bariana
- 👤 Anthony Fung
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 15:33
CPC Classifications
C; C07; C07D; C07D475/00; C07D475/06; C07D475/10
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
14 words
A compound of the formula ##STR2## wherein R is hydrogen, dimethylamino, m-methyl or p-methyl.
Claim 2
Dependent Claim
14 words
A compound of the formula ##STR2## wherein R is hydrogen, dimethylamino, m-methyl or p-methyl.
Claim 3
Dependent Claim
9 words
The compound of claim 1 wherein R is hydrogen.
Claim 4
Dependent Claim
9 words
The compound of claim 1 wherein R is m-methyl.
Claim 5
Dependent Claim
9 words
The compound of claim 1 wherein R is N,N-dimethylamino.
Claim 6
Dependent Claim
13 words
The compound of claim 4 wherein said N,N-dimethylamino group is in the p-position.
Claim 7
Dependent Claim
9 words
The compound of claim 1 wherein R is p-methyl.
Claim 8
Independent Claim
40 words
The method of increasing the urine excretion in a warm-blooded animal consisting essentially in administering to said animal a diuretically sufficient amount of a compound of a formula ##STR3## ##STR4## wherein R is H, Me 2 N, m-Me or p-Me.
Claim 9
Independent Claim
40 words
The method of increasing the urine excretion in a warm-blooded animal consisting essentially in administering to said animal a diuretically sufficient amount of a compound of a formula ##STR3## ##STR4## wherein R is H, Me 2 N, m-Me or p-Me.
Claim 10
Dependent Claim
18 words
The method of claim 7 wherein said amount is a daily dose of between 30 and 500 mg./kg.
Claim 11
Dependent Claim
18 words
The method of claim 7 wherein said amount is a daily dose of betwwen 50 and 250 mg./kg.
Claim 12
Dependent Claim
9 words
The method of claim 9 wherein R is hydrogen.
Claim 13
Dependent Claim
9 words
The method of claim 9 wherein R is m-Me.
Claim 14
Dependent Claim
11 words
The method of claim 9 wherein R is Me 2 N.
Claim 15
Dependent Claim
14 words
The method of claim 12 wherein said Me 2 N is in the p-position.
Claim 16
Dependent Claim
9 words
The method of claim 9 wherein R is p-Me.
Claim 17
Dependent Claim
41 words
A medicinal composition for increasing urine excretion from a warm-blooded animal containing a diuretically effective amount of a compound of the formula ##STR5## wherein R is H, Me 2 N, m-Me or p-Me together with a pharmaceutically acceptable diluent or carrier.
Claim 18
Dependent Claim
41 words
A medicinal composition for increasing urine excretion from a warm-blooded animal containing a diuretically effective amount of a compound of the formula ##STR5## wherein R is H, Me 2 N, m-Me or p-Me together with a pharmaceutically acceptable diluent or carrier.
Claim 19
Dependent Claim
14 words
The composition of claim 15 in the form of a tablet for oral administration.
Claim 20
Dependent Claim
9 words
The composition of claim 16 wherein R is hydrogen.
Claim 21
Dependent Claim
11 words
The composition of claim 16 wherein R is Me 2 N.
Claim 22
Dependent Claim
14 words
The composition of claim 18 wherein said Me 2 N is in the p-position.
Claim 23
Dependent Claim
9 words
The composition of claim 16 wherein R is p-Me.
Claim 24
Dependent Claim
9 words
The composition of claim 16 wherein R is m-Me.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-02-04 | 1983-08-06 | 1984-02-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-02-04 | 1987-08-06 | 1988-02-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-02-04 | 1991-08-06 | 1992-02-05 | $7700.00 | Window Closed / Lapsed |