US4186268A
Expired / Lapsed
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Mercaptoacylpyrrolidine phosphonic acids and related compounds
Assignee: ER Squibb and Sons LLC
•
Filing: 1979-01-29
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Granted: 1980-01-29
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Expires: 1999-01-29
Abstract
Abstract New mercaptoacylpyrrolidine- and mercaptoacylpiperidine phosphonic acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
Inventors
- 👤 Edward W. Petrillo, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 01:01
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/06; C07D211/36; A; A61; A61P; A61P9/00; A61P9/12; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/553; C07F9/572; C07F9/576; C07F9/59
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
54 words
A compound of the formula ##STR11## wherein R and R 1 each is hydrogen, lower alkyl, phenyl-lower alkyl or an alkali metal ion; R 2 is hydrogen, lower alkanoyl, benzoyl or ##STR12## R 3 and R 4 each is hydrogen or lower alkyl; m is 1 or 2; and n is 0 or 1.
Claim 2
Dependent Claim
54 words
A compound of the formula ##STR11## wherein R and R 1 each is hydrogen, lower alkyl, phenyl-lower alkyl or an alkali metal ion; R 2 is hydrogen, lower alkanoyl, benzoyl or ##STR12## R 3 and R 4 each is hydrogen or lower alkyl; m is 1 or 2; and n is 0 or 1.
Claim 3
Dependent Claim
10 words
A compound as in claim 1 wherein m is 1.
Claim 4
Dependent Claim
10 words
A compound as in claim 1 wherein m is 2.
Claim 5
Dependent Claim
14 words
A compound as in claim 1 wherein R and R 1 are both hydrogen.
Claim 6
Dependent Claim
15 words
A compound as in claim 1 wherein R and R 1 are both lower alkyl.
Claim 7
Dependent Claim
15 words
A compound as in claim 1 wherein R and R 1 are both alkali metal.
Claim 8
Dependent Claim
11 words
A compound as in claim 1 wherein R 2 is hydrogen.
Claim 9
Dependent Claim
11 words
A compound as in claim 1 wherein R 2 is ##STR13##
Claim 10
Dependent Claim
43 words
A compound as in claim 2 wherein n is 0 or 1; R and R 1 each is hydrogen, lower alkyl or alkali metal; R 2 is hydrogen or lower alkanoyl; and R 3 and R 4 each is hydrogen or lower alkyl.
Claim 11
Dependent Claim
32 words
A compound as in claim 2 wherein R and R 1 each is lower alkyl; R 2 is lower alkanoyl; R 3 and R 4 each is hydrogen; and n is 1.
Claim 12
Dependent Claim
20 words
A compound as in claim 10 wherein each lower alkyl group is ethyl and the lower alkanoyl group is acetyl.
Claim 13
Dependent Claim
26 words
A compound as in claim 2 wherein R, R 1 , R 2 , R 3 and R 4 each is hydrogen and n is 1.
Claim 14
Dependent Claim
8 words
Lithium salt of the compound of claim 12.
Claim 15
Dependent Claim
28 words
A compound as in claim 2 wherein R, R 1 , R 2 and R 4 each is hydrogen, R 3 is lower alkyl and n is 1.
Claim 16
Dependent Claim
13 words
A compound as in claim 14 wherein the lower alkyl group is methyl.
Claim 17
Dependent Claim
10 words
A compound as in claim 8 where m is 1.
Claim 18
Dependent Claim
28 words
A compound as in claim 3 wherein R, R 1 , R 2 and R 4 each is hydrogen; R 3 is lower alkyl; and n is 1.
Claim 19
Dependent Claim
13 words
A compound as in claim 3 wherein the lower alkyl group is methyl.
Claim 20
Dependent Claim
26 words
A compound as in claim 3 wherein R, R 1 , R 2 , R 3 and R 4 each is hydrogen and n is 1.
Claim 21
Dependent Claim
27 words
A compound as in claim 2 wherein R, R 1 , R 2 and R 4 each is hydrogen, R 3 is methyl and n is 1.
References Cited (Backward Citations)
US4046889A
Cited
US4105776A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-01-28 | 1983-07-30 | 1984-01-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-01-28 | 1987-07-30 | 1988-01-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-01-28 | 1991-07-30 | 1992-01-29 | $7700.00 | Window Closed / Lapsed |