US4184848A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Eliminating turbidity in serum undergoing photometric assay
Assignee: Roche Diagnostics GmbH
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Filing: 1977-09-23
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Granted: 1980-01-22
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Expires: 1997-09-23
Abstract
Abstract An agent for the elimination of turbidity in serum, especially in serum samples wherein photometric measurements are to be made, consisting essentially of one or more mono- or di-esters of polyethylene glycol and fatty acids of 9 to 14 carbon atoms with at most 8 ethylene oxide units per fatty acid moiety in the molecule, said esters having an HLB value of from 8 to 12.8.
Inventors
- 👤 Hans-Georg Batz
- 👤 Brigitte Draeger
- 👤 August W. Wahlefeld
- 👤 Gunter Weimann
- 👤 Wolfgang Gruber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 09:05
CPC Classifications
C; C12; C12Q; C12Q1/00; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25125
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
94 words
Method for eliminating turbidity which interferes with photometric measurements in serum, which method comprises adding to the serum sample an agent comprising essentially an ester component consisting of at least one mono- or di-ester of polyethylene glycol and fatty acids of 9 to 14 carbon atoms with at most 8 ethylene oxide units per fatty acid moiety in the molecule, said ester component having an HLB value between 8 and 12.8, which agent is added to the serum sample in an amount of from 0.5 to 5 weight percent based on said serum sample.
Claim 2
Dependent Claim
94 words
Method for eliminating turbidity which interferes with photometric measurements in serum, which method comprises adding to the serum sample an agent comprising essentially an ester component consisting of at least one mono- or di-ester of polyethylene glycol and fatty acids of 9 to 14 carbon atoms with at most 8 ethylene oxide units per fatty acid moiety in the molecule, said ester component having an HLB value between 8 and 12.8, which agent is added to the serum sample in an amount of from 0.5 to 5 weight percent based on said serum sample.
Claim 3
Dependent Claim
18 words
Method as claimed in claim 1 wherein said serum sample contains turbidity interfering with performing photometric measurements thereon.
Claim 4
Dependent Claim
18 words
Method as claimed in claim 1 wherein said agent comprises an ester component consisting of lauric acid esters.
Claim 5
Dependent Claim
35 words
Method as claimed in claim 1 wherein said mono- or di-ester contains 10 to 40 weight percent of polyethylene glycol esters of 3 to 4 ethylene oxide units per fatty acid moiety in the molecule.
Claim 6
Dependent Claim
16 words
Method as claimed in claim 1 wherein said agent is free of acid and aldehyde traces.
Claim 7
Dependent Claim
14 words
Method as claimed in claim 1 wherein said agent also contains a solubility improver.
Claim 8
Dependent Claim
38 words
Method as claimed in claim 6 containing, as the solubility improver, a low alkanol of 1 to 3 carbon atoms, or a glycol of up to 7 carbon atoms or polyglycol of up to 8 ethylene oxide units.
Claim 9
Dependent Claim
26 words
Method as claimed in claim 6 wherein said solubility improver is one or more tensides which alone are not capable of eliminating or substantially clarifying turbidity.
Claim 10
Dependent Claim
34 words
Method as claimed in claim 8 wherein the tenside contains a polyethylene oxide ether of an alkanol of 8 to 16 carbon atoms in the molecule, which contains 8 to 14 polyethylene oxide units.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-01-21 | 1983-07-23 | 1984-01-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-01-21 | 1987-07-23 | 1988-01-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-01-21 | 1991-07-23 | 1992-01-22 | $7700.00 | Window Closed / Lapsed |