US4181725A
Expired / Lapsed
US
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Method for alleviating psoriasis
Assignee: University of Michigan (System)
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Filing: 1977-05-02
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Granted: 1980-01-01
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Expires: 1997-05-02
Abstract
Abstract Pharmaceutical compositions administered to humans and animals topically for treatment of proliferative skin diseases, primarily psoriasis. The composition comprises a pharmaceutical carrier with at least one active ingredient selected from the group consisting of para bromophenacyl bromide, alpha tocopherol, mepacrine, chloroquine, hydroxychloroquine, dibucaine, tetracaine, lidocaine, butacaine, procaine, ethylene diamine tetra acetic acid and ethylene glycol bis( beta -amino ethyl ether)-N-N' tetra acetic acid; the compositions may also include one or more unsaturated aliphatic compounds, a glucocorticoid and a prostaglandin.
Inventors
- 👤 John J. Voorhees
- 👤 Sven R. Hammarstrom
- 👤 Mats A. Hamberg
- 👤 Bengt I. Samuelsson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 12:49
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/35; A61K31/352; A61K31/353; A61K31/355; A61K31/12; A61K31/16; A61K31/165; A61K31/185; A61K31/19; A61K31/20; A61K31/21; A61K31/215; A61K31/235; A61K31/24; A61K31/245; A61K31/395; A61K31/435; A61K31/47; A61P; A61P17/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
92 words
A method for alleviating psoriasis which comprises administering to the afflicted human or animal a composition containing as its active component at least one compound selected from the group consisting of para bromophenacyl bromide, alpha tocopherol, mepacrine, chloroquine, hydroxychloroquine, dibucaine, tetracaine, lidocaine, butacaine, procaine, ethylene diamine tetra acetic acid and ethylene glycol bis(β-amino ethyl ether)-N-N' tetra acetic acid, said compound being in association with the pharmaceutical carrier, wherein said active component is present in an amount which is effective to alleviate psoriasis in the range of about 0.1% to about 20% w/v.
Claim 2
Independent Claim
92 words
A method for alleviating psoriasis which comprises administering to the afflicted human or animal a composition containing as its active component at least one compound selected from the group consisting of para bromophenacyl bromide, alpha tocopherol, mepacrine, chloroquine, hydroxychloroquine, dibucaine, tetracaine, lidocaine, butacaine, procaine, ethylene diamine tetra acetic acid and ethylene glycol bis(β-amino ethyl ether)-N-N' tetra acetic acid, said compound being in association with the pharmaceutical carrier, wherein said active component is present in an amount which is effective to alleviate psoriasis in the range of about 0.1% to about 20% w/v.
Claim 3
Independent Claim
48 words
A method for alleviating psoriasis which comprises administering to an afflicted human or animal a composition containing hydroxychloroquine in association with a pharmaceutical carrier wherein said hydroxychloroquine is present in an amount which is effective to alleviate psoriasis in the range of about 0.1% to about 20% w/v.
Claim 4
Independent Claim
48 words
A method for alleviating psoriasis which comprises administering to an afflicted human or animal a composition containing hydroxychloroquine in association with a pharmaceutical carrier wherein said hydroxychloroquine is present in an amount which is effective to alleviate psoriasis in the range of about 0.1% to about 20% w/v.
Claim 5
Independent Claim
48 words
A method for alleviating psoriasis which comprises administering to an afflicted human or animal a composition containing chloroquine in association with a pharmaceutical carrier wherein said chloroquine is present in an amount which is effective to alleviate psoriasis in the range of about 0.1% to about 20% w/v.
Claim 6
Independent Claim
48 words
A method for alleviating psoriasis which comprises administering to an afflicted human or animal a composition containing chloroquine in association with a pharmaceutical carrier wherein said chloroquine is present in an amount which is effective to alleviate psoriasis in the range of about 0.1% to about 20% w/v.
Claim 7
Independent Claim
50 words
A method for alleviating psoriasis which comprises administering to an afflicted human or animal a composition containing parabromophenacyl bromide in association with a pharmaceutical carrier wherein said parabromophenacyl bromide is present in an amount which is effective to alleviate psoriasis in the range of about 0.1% to about 20% w/v.
Claim 8
Independent Claim
50 words
A method for alleviating psoriasis which comprises administering to an afflicted human or animal a composition containing parabromophenacyl bromide in association with a pharmaceutical carrier wherein said parabromophenacyl bromide is present in an amount which is effective to alleviate psoriasis in the range of about 0.1% to about 20% w/v.
Claim 9
Independent Claim
138 words
A method for alleviating psoriasis which comprises administering to the afflicted human or animal a composition containing as its active component at least one compound selected from the group consisting of para bromophenacyl bromide, alpha tocopherol, mepacrine, chloroquine, hydroxychloroquine, dibucaine, tetracaine, lidocaine, butacaine, procaine, ethylene diamine tetra acetic acid and ethylene glycol bis(β-amino ethyl ether)-N-N' tetra acetic acid, and at least one compound having the formula CH.sub.3 (CH.sub.2).sub.m (C.tbd.C-CH.sub.2).sub.a (CH.sub.2).sub.b CO.sub.2 H wherein m is an integer from 4 to 9 inclusive, a is an integer of 2 to 5 and b is an integer of from 0 to 8, and the alkyl esters of such compounds, said compounds being in association with a pharmaceutical carrier wherein said compounds are present in an amount effective to alleviate psoriasis in the range of about 0.1% to about 20% w/v.
Claim 10
Independent Claim
138 words
A method for alleviating psoriasis which comprises administering to the afflicted human or animal a composition containing as its active component at least one compound selected from the group consisting of para bromophenacyl bromide, alpha tocopherol, mepacrine, chloroquine, hydroxychloroquine, dibucaine, tetracaine, lidocaine, butacaine, procaine, ethylene diamine tetra acetic acid and ethylene glycol bis(β-amino ethyl ether)-N-N' tetra acetic acid, and at least one compound having the formula CH.sub.3 (CH.sub.2).sub.m (C.tbd.C-CH.sub.2).sub.a (CH.sub.2).sub.b CO.sub.2 H wherein m is an integer from 4 to 9 inclusive, a is an integer of 2 to 5 and b is an integer of from 0 to 8, and the alkyl esters of such compounds, said compounds being in association with a pharmaceutical carrier wherein said compounds are present in an amount effective to alleviate psoriasis in the range of about 0.1% to about 20% w/v.
Claim 11
Dependent Claim
22 words
A method in accordance with claim 5, wherein said compounds are present in an amount between about 10% and about 20% w/v.
Claim 12
Dependent Claim
16 words
A method in accordance with claim 5, wherein said compounds present are hydroxychloroquine and eicosa-5,8,11,14-tetraynoic acid.
Claim 13
Dependent Claim
15 words
A method in accordance with claim 5, wherein said compounds are hydroxychloroquine and 5,8,11-eicosatriynoic acid.
Claim 14
Dependent Claim
15 words
A method in accordance with claim 5, wherein said compounds are parabromophenacyl bromide and hydroxychloroquine.
Claim 15
Dependent Claim
15 words
A method in accordance with claim 5, wherein said compounds are parabromophenacyl bromide and chloroquine.
Claim 16
Dependent Claim
18 words
A method in accordance with claim 5, wherein said compounds are alpha tocopherol, parabromophenacyl bromide, and 5,8,11-eicosatriynoic acid.
Claim 17
Dependent Claim
33 words
A method in accordance with claim 5, wherein said compounds are hydroxychloroquine, eicosa-5,8,11,14-tetraynoic acid, alpha tocopherol, and at least one prostaglandin selected from the group consisting of PGE 1 and PGE 2 .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-31 | 1983-07-02 | 1984-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-31 | 1987-07-02 | 1988-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-31 | 1991-07-02 | 1992-01-01 | $7700.00 | Window Closed / Lapsed |