US4180559A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Coated 1-(2-chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine compositions
Assignee: Richardson Vicks Inc
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Filing: 1978-12-01
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Granted: 1979-12-25
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Expires: 1998-12-01
Abstract
Abstract A coated 1-(2-chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine composition, suitable for pharmaceutical use.
Inventors
- 👤 Harold E. Huber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:08
CPC Classifications
C; C07; C07D; C07D313/00; C07D313/02; C07D313/06; C07D313/10; C07D313/14; A; A61; A61K; A61K9/00; A61K9/20; A61K9/28; A61K9/2806; A61K9/2833; A61K9/286; A61K9/2866; A61K9/48; A61K9/50; A61K9/5073; A61K9/5078; C07C; C07C45/00; C07C45/61; C07C45/67; C07C45/68; C07C45/70; C07C45/71; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07C59/66; C07C59/68
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
81 words
A coated, duodenal soluble, pharmaceutical composition suitable for oral ingestion comprising a core having from 6 to 33% by weight of 1-(2-chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine or a pharmaceutically acceptable salt thereof, and from 67 to 94% by weight of an inert pharmaceutical carrier; and a duodenal soluble coating having from 7 to 15% by weight of said core of hydroxypropyl methylcellulose phthalate, said coating having a thickness of from 0.1 to 0.2 mm and which dissolves at a pH of about 5.0 to 5.5.
Claim 2
Dependent Claim
81 words
A coated, duodenal soluble, pharmaceutical composition suitable for oral ingestion comprising a core having from 6 to 33% by weight of 1-(2-chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine or a pharmaceutically acceptable salt thereof, and from 67 to 94% by weight of an inert pharmaceutical carrier; and a duodenal soluble coating having from 7 to 15% by weight of said core of hydroxypropyl methylcellulose phthalate, said coating having a thickness of from 0.1 to 0.2 mm and which dissolves at a pH of about 5.0 to 5.5.
Claim 3
Dependent Claim
15 words
A composition according to claim 1 wherein the 1-(2-chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine is present as the maleate salt.
Claim 4
Dependent Claim
16 words
A composition according to claim 1 which is in the form of a duodenal-soluble coated tablet.
Claim 5
Dependent Claim
78 words
A duodenal-soluble coated pharmaceutical tablet for oral ingestion comprising from about 10 to about 50 parts by weight of 1-(2-chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine or a pharmaceutically acceptable salt thereof, from about 100 to about 200 parts by weight of an inert pharmaceutical carrier, and from about 10 to about 30 parts by weight of a duodenal soluble coating of hydroxypropyl methylcellulose phthalate having a thickness of from 0.1 to 0.2 mm and dissolving at a pH of from 5.0 to 5.5.
Claim 6
Dependent Claim
78 words
A duodenal-soluble coated pharmaceutical tablet for oral ingestion comprising from about 10 to about 50 parts by weight of 1-(2-chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine or a pharmaceutically acceptable salt thereof, from about 100 to about 200 parts by weight of an inert pharmaceutical carrier, and from about 10 to about 30 parts by weight of a duodenal soluble coating of hydroxypropyl methylcellulose phthalate having a thickness of from 0.1 to 0.2 mm and dissolving at a pH of from 5.0 to 5.5.
Claim 7
Dependent Claim
15 words
A tablet according to claim 4 wherein the 1-(2-chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine is present as the maleate salt.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-24 | 1983-06-25 | 1983-12-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-24 | 1987-06-25 | 1987-12-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-24 | 1991-06-25 | 1991-12-25 | $7700.00 | Window Closed / Lapsed |