Stabilized prostaglandin E composition

Claim 2

A stabilized prostaglandin E composition comprising a prostaglandin E having incorporated therein a stabilizing amount of methylhesperidin.

Claim 3

A composition according to claim 1 wherein the ratio by weight of methylhesperidin to the prostaglandin E is in the range of from 0.1 to 10,000.

Claim 4

A composition according to claim 1 wherein the ratio by weight of methylhesperidin to the prostaglandin E is in the range of from 1 to 1,000.

Claim 5

A composition according to claim 1 wherein the prostaglandin E is at least one compound selected from the group consisting of prostaglandin E 2 , prostaglandin E 1 , 13,14-dihydroprostaglandin E 1 , 13,14-dihydroprostaglandin E 2 , 15-methylprostaglandin E 2 , 15-methylprostaglandin E 1 , 15-methyl-13,14-dihydroprostaglandin E 1 , 16-methylprostaglandin E 2 , 16-methylprostaglandin E 1 , 16-methyl-13,14-dihydroprostaglandin E 1 , 16,16-dimethylprostaglandin E 2 , 16,16-dimethylprostaglandin E 1 , 16,16-dimethyl-13,14-dihydroprostaglandin E 1 , 16,16-propanoprostaglandin E 2 , 16,16-propanoprostaglandin E 1 , 16,16-propano-13,14-dihydroprostaglandin E 1 , 16-cyclohexyl-ω-tetranorprostaglandin E 2 , 16-phenyl-ω-tetranorprostaglandin E 2 , 17-phenyl-ω-trinorprostaglandin E 2 , 16-phenoxy-ω-tetranorprostaglandin E 2 , 16-m-chlorophenoxy-ω-tetranorprostaglandin E 2 , and their alkyl esters (the alkyl group having from 1 to 12 carbon atoms) and aralkyl esters (the aralkyl group having from 7 to 15 carbon atoms), and; prostaglandins E represented by the general formula: ##STR2## wherein R 1 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms; R 4 and R 5 may be the same or different, and each of R 4 and R 5 represents independently a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms or a fluorine atom; R 2 and R 3 may be the same or different, and each of R 2 and R 3 represents independently a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms or a protective group for the hydroxyl group; R 6 represents an alkyl group having from 1 to 10 carbon atoms, a substituted alkyl group having from 1 to 15 carbon atoms, a cycloalkyl group having from 1 to 10 carbon atoms, a substituted cycloalkyl group (the cycloalkyl group having from 1 to 10 carbon atoms), an aryl group having from 6 to 15 carbon atoms, or a substituted aryl group (the aryl group having from 6 to 15 carbon atoms); Z represents a single bond, a sulfur atom or an oxygen atom; A represents --CH 2 CH 2 -- or cis--CH═CH--; B represents --CH 2 CH 2 --, --C═C-- or trans--CH═CH--; X represents an alkylene group having from 1 to 5 carbon atoms or a substituted alkylene group having from 1 to 10 carbon atoms, and; Y represents a carboxyl group, an alkoxycarbonyl group having from 2 to 13 carbon atoms, a hydroxymethyl group or an unsubstituted or substituted alkoxymethyl group (the alkoxymethyl group having from 2 to 6 carbon atoms).

Claim 6

A composition according to claim 1 wherein the methylhesperidin is a product obtained by methylating hesperidin.

Claim 7

A composition according to claim 1 which has a water content of less than about 5% by weight.