US4178439A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sulphated ion exchanger and method for preparation thereof
Assignee: Development Finance Corp of New Zealand
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Filing: 1977-03-01
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Granted: 1979-12-11
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Expires: 1997-03-01
Abstract
Abstract The invention relates to a novel sulphated cationic ion exchanger and to a method for preparation thereof. In addition it relates to a method of improving the capacity of an exchange matrix to receive sulphated groups. Although the general attraction of sulphate groups to proteins is known we have found that sulphated ion exchangers selectively bind lipoproteins in blood serum or plasma under suitable conditions. We have also discovered that when hydroxyalkyl groups are introduced into the ion exchanger matrix its capacity for taking up sulphate groups is unexpectedly increased. A method of use of the ion exchanger is also described.
Inventors
- 👤 John S. Ayers
- 👤 David R. Husbands
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 18:46
CPC Classifications
B; B01; B01J; B01J39/00; B01J39/08; B01J39/16; B01J39/18; B01J39/22; C; C08; C08B; C08B15/00; C08B15/005; C08B37/00; C08B5/00; C08B5/14
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
69 words
A cationic ion exchanger comprising a water insoluble hydrophilic, water swellable matrix; a plurality of sulphate groups chemically bonded to said matrix, the ion exchange capacity of said exchanger being provided by said sulphate groups; said matrix being a member selected from the group consisting of: (a) a cross-linked carbohydrate, and, (b) a cross-linked carbohydrate having a plurality of hydroxy C a -C 4 alkyl groups chemically bonded thereto.
Claim 2
Dependent Claim
69 words
A cationic ion exchanger comprising a water insoluble hydrophilic, water swellable matrix; a plurality of sulphate groups chemically bonded to said matrix, the ion exchange capacity of said exchanger being provided by said sulphate groups; said matrix being a member selected from the group consisting of: (a) a cross-linked carbohydrate, and, (b) a cross-linked carbohydrate having a plurality of hydroxy C a -C 4 alkyl groups chemically bonded thereto.
Claim 3
Dependent Claim
17 words
The ion exchanger according to claim 1 wherein the degree of sulphation is at least 0.5 meq/g.
Claim 4
Dependent Claim
27 words
The ion exchanger according to claim 1 wherein said matrix is regenerated cellulose cross-linked with at least 50% epichlorohydrin expressed as volume epichlorohydrin to weight of cellulose.
Claim 5
Dependent Claim
47 words
The ion exchanger according to claim 3 wherein said matrix is regenerated cellulose cross-linked with at least 5% volume of epichlorohydrin to weight cellulose, there being present hydroxypropyl groups introduced by at least 30% propylene oxide expressed as volume propylene oxide added to weight of cellulose matrix.
Claim 6
Dependent Claim
62 words
The ion exchanger according to claim 1 wherein said cross-linked carbohydrate is a member selected from the group consisting of an unsubstituted cross-linked polysaccharide, an unsubstituted hydroxyl containing derivative thereof, a cross-linked polysaccharide substituted with a plurality of hydroxy C 2 -C 4 alkyl groups and hydroxyl containing polysaccharide derivative substituted with a plurality of hydroxy C 2 -C 4 alkyl groups.
Claim 7
Dependent Claim
63 words
The ion exchanger according to claim 5 wherein said cross-linked polysaccharide is a member selected from the group consisting of unsubstituted cross-linked cellulose in any one of its native fibrous, microgranular, microcrystalline or regenerated forms, and a cross-linked cellulose in any one of its native fibrous, microgranular, microcrystalline or regenerated forms substituted with a plurality of hydroxy C 2 -C 4 alkyl groups.
Claim 8
Dependent Claim
30 words
The ion exchanger according to claim 6 wherein said matrix is microgranular or microcrystalline cellulose cross-linked with less than 25% of epichlorohydrin expressed as volume epichlorohydrin to weight of cellulose.
Claim 9
Dependent Claim
28 words
The ion exchanger according to claim 7 wherein said microgranular or microcrystalline cellulose is cross-linked with from 5-10% of epichlorohydrin expressed as volume epichlorohydrin to weight of cellulose.
Claim 10
Dependent Claim
35 words
The ion exchanger according to claim 1 wherein said cross-linked carbohydrate matrix is substituted to a degree of substitution produced by reaction of at least 20% volume of hydroxyalkylating agent to weight of the matrix.
Claim 11
Dependent Claim
72 words
A process for the preparation of a cationic ion exchanger which comprises the steps of: hydroxy C 2 -C 4 alkylating a water insoluble, hydrophilic water swellable cross-linked cellulose selected from the group consisting of native fibrous, microgranular, microcrystalline and regenerated cellulose, said cellulose being further selected from the group consisting of unsubstituted cellulose and cellulose substituted by hydroxy C 2 -C 4 alkyl groups; and sulphating the product of step 1.
Claim 12
Dependent Claim
72 words
A process for the preparation of a cationic ion exchanger which comprises the steps of: hydroxy C 2 -C 4 alkylating a water insoluble, hydrophilic water swellable cross-linked cellulose selected from the group consisting of native fibrous, microgranular, microcrystalline and regenerated cellulose, said cellulose being further selected from the group consisting of unsubstituted cellulose and cellulose substituted by hydroxy C 2 -C 4 alkyl groups; and sulphating the product of step 1.
Claim 13
Dependent Claim
18 words
The method according to claim 10 wherein said matrix is hydroxy alkylated by the addition of propylene oxide.
Claim 14
Dependent Claim
33 words
The method according to claim 10 wherein said sulphating agent is either the reaction product of sulphur trioxide and a Lewis Base or the reaction product of chlorosulphonic acid and a Lewis base.
Claim 15
Dependent Claim
15 words
A method to claim 12 wherein said sulphating agent is a pyridine sulphur trioxide complex.
Claim 16
Dependent Claim
54 words
The method according to claim 12 wherein said sulphating is conducted in dimethylformamide or formamide at a temperature of between 0° and 60° C. for from 0.5 to 6 hours, there being from 2 to 20 millimoles sulphating agent per gram of matrix and 5-25 ml of dimethylformamide or formamide per gram of matrix.
Claim 17
Dependent Claim
50 words
The method according to claim 12 wherein said sulphating is conducted in pyridine at a temperature of between 50° and 90° C. for from 0.5 to 6 hours, there being from 2 to 20 millimoles sulphating agent per gram of matrix and 5-25 ml of pyridine per gram of matrix.
Claim 18
Dependent Claim
25 words
The method according to claim 10 wherein said matrix is preswollen for from 0 to 16 hours prior to the addition of a sulphating agent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-10 | 1983-06-11 | 1983-12-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-10 | 1987-06-11 | 1987-12-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-10 | 1991-06-11 | 1991-12-11 | $7700.00 | Window Closed / Lapsed |