US4177344A
Expired / Lapsed
US
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Anhydro-sugars
Assignee: Novartis Corp
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Filing: 1977-09-16
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Granted: 1979-12-04
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Expires: 1997-09-16
Abstract
Abstract The invention relates to novel 1,6-anhydro-β-D-hexopyranose derivatives of the formula I ##STR1## in which R 2 is hydrogen, methyl or aromatic acyl, R 3 and R 4 are alkyl, alkenyl or aralkyl and one of the radicals R 3 and R 4 is also an aroyl radical and R 4 can also be hydrogen, with the proviso that the radicals R 3 and R 4 together contain at least 3 carbon atoms and, if R 4 is the benzyl radical, the radical R 3 contains at least 2 carbon atoms, and, if one of the radicals R 3 and R 4 is an aroyl radical, R 2 is hydrogen. These compounds especially the 1,6-anhydro-3,4-di-O-benzyl-β-D-glucopyranose or the 1,6-anhydro-β-D-glucopyranose, can be used as fibrinolytic agents and thrombolytic agents.
Inventors
- 👤 Gerhard Baschang
- 👤 Jaroslav Stanek
- 👤 Alberto Rossi
- 👤 Alex Sele
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 00:54
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/18; A; A61; A61P; A61P29/00; C07H19/00; C07H19/01
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
153 words
1,6-Anhydro-β-D-hexopyranose derivatives of the formula ##STR7## wherein R 2 is hydrogen, methyl, benzoyl, benzoyl substituted by halogen, lower alkyl, lower alkoxy, hydroxy or lower alkanoyl, or naphthoyl, one of the two radicals R 3 and R 4 is lower alkyl, phenyl-methyl, phenyl-methyl substituted by halogen, lower alkyl, lower alkoxy, hydroxy or lower alkanoyloxy, or naphthyl-methyl and the other is lower alkyl, phenyl-methyl, phenyl-methyl substituted by halogen, lower alkyl, lowr alkoxy, hydroxy or lower alkanoyloxy, naphthyl-methyl, benzoyl, benzoyl substituted by halogen, lower alkyl, lowr alkoxy, hydroxy or lower alkanoyloxy, or naphthoyl and R 4 can also be hydrogen, with the proviso that the radicals R 3 and R 4 together contain at least 3 carbon atoms, and when R 4 is benzyl, R 3 contains at least 2 carbon atoms, and when one of the radicals R 3 and R 4 is benzoyl, benzoyl substituted as defined above or naphthoyl, R 2 is hydrogen.
Claim 2
Dependent Claim
153 words
1,6-Anhydro-β-D-hexopyranose derivatives of the formula ##STR7## wherein R 2 is hydrogen, methyl, benzoyl, benzoyl substituted by halogen, lower alkyl, lower alkoxy, hydroxy or lower alkanoyl, or naphthoyl, one of the two radicals R 3 and R 4 is lower alkyl, phenyl-methyl, phenyl-methyl substituted by halogen, lower alkyl, lower alkoxy, hydroxy or lower alkanoyloxy, or naphthyl-methyl and the other is lower alkyl, phenyl-methyl, phenyl-methyl substituted by halogen, lower alkyl, lowr alkoxy, hydroxy or lower alkanoyloxy, naphthyl-methyl, benzoyl, benzoyl substituted by halogen, lower alkyl, lowr alkoxy, hydroxy or lower alkanoyloxy, or naphthoyl and R 4 can also be hydrogen, with the proviso that the radicals R 3 and R 4 together contain at least 3 carbon atoms, and when R 4 is benzyl, R 3 contains at least 2 carbon atoms, and when one of the radicals R 3 and R 4 is benzoyl, benzoyl substituted as defined above or naphthoyl, R 2 is hydrogen.
Claim 3
Dependent Claim
22 words
A compound of the formula ##STR8## in which R 2 , R 3 and R 4 are as defined in claim 1.
Claim 4
Dependent Claim
30 words
A compound of the formula (Ia) according to claim 2, in which R 3 is a benzyl radical and R 2 and R 4 are as defined in claim 2.
Claim 5
Dependent Claim
31 words
A compound of the formula (Ia) according to claim 2, in which R 2 is hydrogen or methyl, R 3 is a benzyl radical and R 4 is hydrogen or benzyl.
Claim 6
Dependent Claim
26 words
A compound of the formula (Ia) according to claim 2, wherein R 3 and R 4 are benzyl radicals, and R 2 is hydrogen or benzoyl.
Claim 7
Dependent Claim
23 words
A compound of the formula (Ia) according to claim 2, wherein R 3 is benzyl, and R 2 and R 4 are hydrogen.
Claim 8
Dependent Claim
135 words
A compound of the formula (Ia) according to claim 2, in which R 2 is hydrogen, benzoyl, benzoyl substituted by halogen, lower alkyl, lower alkoxy, hydroxy or lower alkanoyloxy, or naphthoyl, R 3 is lower alkyl, phenyl-methyl, phenyl-methyl substituted by halogen, lower alkyl, lower alkoxy, hydroxy or lower alkanoyloxy, or napthyl-methyl and R 4 is hydrogen, lower alkyl, phenyl-methyl, phenyl-methyl substituted by halogen, lower alkyl, lower alkoxy, hydroxy or lower alkanoyloxy, or naphthyl-methyl, benzoyl, benzoyl substituted by halogen, lower alkyl, lower alkoxy, hydroxy or lower alkanoyloxy, or naphthoyl, with the proviso that R 3 and R 4 together contain at least 3 carbon atoms and, when R 4 is benzyl, R 3 contains at least 2 carbon atoms and, when R 4 is benzoyl, benzoyl substituted as defined above or naphthoyl, R 2 is hydrogen.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-03 | 1983-06-04 | 1983-12-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-03 | 1987-06-04 | 1987-12-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-03 | 1991-06-04 | 1991-12-04 | $7700.00 | Window Closed / Lapsed |