US4175119A
Expired / Lapsed
US
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Composition and method to prevent accidental and intentional overdosage with psychoactive drugs
Assignee: Individual
•
Filing: 1978-01-11
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Granted: 1979-11-20
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Expires: 1998-01-11
Abstract
Abstract A composition and method of inducing emesis to preclude death from accidental or intentional overdosage of a therapeutic composition. The surface of the therapeutic composition is coated with an emetic chemical of such quantity that if the therapeutic composition is consumed in moderation or in accordance with the prescription, no emesis occurs; but if consumed excessively and not in accordance with the prescription, emesis results to render the therapeutic composition harmless and precludes death or serious illness.
Inventors
- 👤 Garry L. Porter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 17:12
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2086; A61K9/209
Claims Analysis
Total Claims: 55
Claim 1
Independent Claim
177 words
A method of inducing emesis to preclude death from accidental or intentional overdosage of a therapeutic composition, which is normally of the type which if ingested by prescription is safe, but if excessively ingested is lethal, comprising the steps of: a. coating the surface of the therapeutic composition with between about 0.25 and 2.0 mg. of an emetic chemical comprising a major proportion of methyl cephaeline and cephaeline and a minor proportion of psychotrine, O-methylpsychotrine, and emetamine; b. controlling the quantity of said emetic chemical coated on the surface of the therapeutic composition such that no emesis ensues if normal prescription directions are followed or if no overdosage occurs; c. ingesting excessive quantities by a being of said therapeutic composition of step (b), said excessive quantities comprising an accumulation of a total dosage of at least 21 mg. of the emetic chemical; and, d. emesis by said being of the ingested excessive quantities of coated therapeutic composition of step (c) in order to render the therapeutic compositions harmless and preclude death or serious illness to said being.
Claim 2
Independent Claim
177 words
A method of inducing emesis to preclude death from accidental or intentional overdosage of a therapeutic composition, which is normally of the type which if ingested by prescription is safe, but if excessively ingested is lethal, comprising the steps of: a. coating the surface of the therapeutic composition with between about 0.25 and 2.0 mg. of an emetic chemical comprising a major proportion of methyl cephaeline and cephaeline and a minor proportion of psychotrine, O-methylpsychotrine, and emetamine; b. controlling the quantity of said emetic chemical coated on the surface of the therapeutic composition such that no emesis ensues if normal prescription directions are followed or if no overdosage occurs; c. ingesting excessive quantities by a being of said therapeutic composition of step (b), said excessive quantities comprising an accumulation of a total dosage of at least 21 mg. of the emetic chemical; and, d. emesis by said being of the ingested excessive quantities of coated therapeutic composition of step (c) in order to render the therapeutic compositions harmless and preclude death or serious illness to said being.
Claim 3
Dependent Claim
18 words
The method of claim 1 additionally including coating said therapeutic composition with an opaque means after step (b).
Claim 4
Dependent Claim
13 words
The method of claim 1 wherein said therapeutic composition is a muscle relaxant.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein said therapeutic composition is an antihistamine.
Claim 6
Dependent Claim
25 words
The method of claim 1 wherein said therapeutic composition is selected from the group consisting of perphenazine and amitriptylline, perphenazine and amitriptylline, and mixtures thereof.
Claim 7
Dependent Claim
57 words
The method of claim 1 wherein said emetic chemical comprises between about 40% wt. and 85% wt. of methyl cephaeline, between about 10% wt. and 40% wt. of cephaeline, between about 2% wt. and 12% wt. of psychotrine, between about 1% wt. and 6% wt. of O-methylpsychotrine, and between about 1% wt. of 6% wt. of emetamine.
Claim 8
Dependent Claim
24 words
The method of claim 6 wherein said controlling step (d) comprises insuring that said emetic chemical does not exceed 2 mg per therapeutic composition.
Claim 9
Dependent Claim
29 words
The method of claim 7 wherein said emetic chemical includes between about 1% wt. and 6% wt. of ipecamine and between about 1% wt. and 6% wt. of hydroipecamine.
Claim 10
Dependent Claim
20 words
The method of claim 8 wherein said emetic chemical includes between about 1% wt. and 6% wt. of ipecacuanhic acid.
Claim 11
Dependent Claim
20 words
The methof of claim 9 wherein said emetic chemical comprises between about 1% wt. and 6% wt. of emetine hydrochloride.
Claim 12
Dependent Claim
13 words
The method of claim 1 wherein said therapeutic composition is a neuroleptic drug.
Claim 13
Dependent Claim
13 words
The method of claim 1 wherein said therapeutic composition is an anxiolytic/minor tranquilizer.
Claim 14
Dependent Claim
12 words
The method of claim 1 wherein said therapeutic composition is a sedative-hypnotic.
Claim 15
Dependent Claim
12 words
The method of claim 1 wherein said therapeutic composition is lithium carbonate.
Claim 16
Dependent Claim
11 words
The method of claim 1 wherein said therapeutic composition is methyl-phenidate.
Claim 17
Dependent Claim
12 words
The method of claim 1 wherein said therapeutic composition is an anticonvulsant.
Claim 18
Dependent Claim
13 words
The method of claim 1 wherein said therapeutic composition is an antiparkinsonian drug.
Claim 19
Dependent Claim
12 words
The method of claim 1 wherein said therapeutic composition is an antidepressant.
Claim 20
Dependent Claim
12 words
The method of claim 1 wherein said therapeutic composition is an anorectic.
Claim 21
Dependent Claim
12 words
The method of claim 1 wherein said therapeutic composition is an analgesic.
Claim 22
Dependent Claim
62 words
A therapeutic composition adapted to prevent drug overdosage and adapted for oral administration in addition to therapeutic ingredients having psychoactive characteristics comprising a coating on the surface of said therapeutic composition, said coating including between about 0.25 to 2.0 mg. of an emetic chemical comprising a major proportion of methyl cephaeline and cephaeline, and a minor proportion of psychotrine, O-methylpsychotrine and emetamine.
Claim 23
Dependent Claim
62 words
A therapeutic composition adapted to prevent drug overdosage and adapted for oral administration in addition to therapeutic ingredients having psychoactive characteristics comprising a coating on the surface of said therapeutic composition, said coating including between about 0.25 to 2.0 mg. of an emetic chemical comprising a major proportion of methyl cephaeline and cephaeline, and a minor proportion of psychotrine, O-methylpsychotrine and emetamine.
Claim 24
Dependent Claim
43 words
The therapeutic composition of claim 21 wherein said therapeutic composition is an antihistamine selected from the group consisting of dimenhydrinate, pseudo-ephedrine, trimeprazine, quasaifenesin, chlorpheniramine, phenylpropanolamine and caramiphen, chlorpheniramine and phenylpropanolamine, Ornade, promethazine HCI, phenylpropanolamine, pheniramine, pyrilamine, Pyribenzamine, tri-methobenzamide, diphenhydramine, chlorpheniramine, and mixtures thereof.
Claim 25
Dependent Claim
27 words
The therapeutic composition of claim 21 wherein said therapeutic composition is selected from the group consisting of perphenazine and amitriptylline, perphenazine and amitriptylline, Triavil, and mixtures thereof.
Claim 26
Dependent Claim
39 words
The therapeutic composition of claim 21 wherein said therapeutic composition is an analgesic selected from the group consisting of narcotics, pentazocine HCI, acetylsalicylic acid, butalbital, phenacetin, ASA, and caffiene, propoxyphene, propoxyphene napsylate, chlorpheniramine and ASA, acetaminophen, and mixtures thereof.
Claim 27
Dependent Claim
25 words
The therapeutic composition of claim 24 wherein said narcotics is selected from the group consisting of dolophin, meperedine, oxycodone, hydromorphine HCI, codiene, and mixtures thereof.
Claim 28
Dependent Claim
29 words
The therapeutic composition of claim 21 wherein said therapeutic composition is a muscle relaxant selected from the group consisting of orphenadrine citrate, chlorzoxazene, carisoprodol, methocarbomol, phenylbutazone, and mixtures thereof.
Claim 29
Dependent Claim
16 words
The therapeutic composition of claim 21 additionally including an opaque coating means surrounding said emetic chemical.
Claim 30
Dependent Claim
58 words
The therapeutic composition of claim 21 wherein said emetic chemical comprises between about 40% wt. and 85% wt. of methyl cephaeline, between about 10% wt. and 40% wt. of cephaeline, between about 2% wt. and 12% wt. of psychotrine, between about 1% wt. and 6% wt. of O-methylpsychotrine, and between about 1% wt. and 6% wt. of emetamine.
Claim 31
Dependent Claim
31 words
The therapeutic composition of claim 28 wherein said emetic chemical additionally includes between about 1% wt. and 6% wt. of ipecamine and between about 1% wt. and 6% wt. of hydro-ipecamine.
Claim 32
Dependent Claim
22 words
The therapeutic composition of claim 29 wherein said emetic chemical additionally includes between about 1% wt. and 6% wt. of ipecacuanhic acid.
Claim 33
Dependent Claim
22 words
The therapeutic composition of claim 30 wherein said emetic chemical additionally includes between about 1% wt. and 6% wt. of emetine hydrochloride.
Claim 34
Dependent Claim
34 words
The therapeutic composition of claim 21 wherein said therapeutic composition is a neuroleptic drug selected from the group consisting of phenothiazines, thioxanthines, butyrophenones, rauwolfia compounds, benzoquinolizine, phenylpiperazine, acridan, indolic derivatives, loxapine, and mixtures thereof.
Claim 35
Dependent Claim
34 words
The therapeutic composition of claim 32 wherein said phenothiazines is selected from the group consisting of chlorpromazine, thioridiazine, trifluooperazine, fluphenazine, promazine, triflupromazine, mesoridazine, piperacetazine, acetophenazine, butaperazine, carphenazine, perphenazine, prochlorperazine, thiopropazine, thioproperazine, and mixtures thereof.
Claim 36
Dependent Claim
21 words
The therapeutic composition of claim 32 wherein said butyrophenones is selected from the group consisting of haloperidol, triperidal, and mixtures thereof.
Claim 37
Dependent Claim
23 words
The therapeutic composition of claim 32 wherein said rauwolfia compound is selected from the group consisting of rauwolfia, rauwolfia serpintina, and mixtures thereof.
Claim 38
Dependent Claim
11 words
The therapeutic composition of claim 32 wherein said benzoquinolizines is tetrabinazine.
Claim 39
Dependent Claim
11 words
The therapeutic composition of claim 32 wherein said phenylpiperazine is oxypertine.
Claim 40
Dependent Claim
12 words
The therapeutic composition of claim 32 wherein said indolic derivatives is molindone.
Claim 41
Dependent Claim
28 words
The therapeutic composition of claim 21 wherein said theropeutic composition is an anxiolytic-minor tranquilizer selected from the group consisting of benzodiazepines, diphenylmethanes, hydroxyzine, chlormezanone, meprobamate, and mixtures thereof.
Claim 42
Dependent Claim
25 words
The therapuetic composition of claim 39 wherein said benzodiazepines is selected from the group consisting of diazepam, oxazepam, chlordiazepoxide, chlordiazepoxide and clidinium, and mixtures thereof.
Claim 43
Dependent Claim
22 words
The therapeutic composition of claim 39 wherein said hydroxyzine is selected from the group consisting of hydroxyzine, hydroxyzine pamoate, and mixtures thereof.
Claim 44
Dependent Claim
30 words
The therapeutic composition of claim 21 wherein said therapeutic composition of a sedative-hypnotic selected from the group consisting of barbiturates, glutethimide, fluazepam, methprylon, ethchlorynol, Promethazine, chloral-hydrate, methaqualone, and mixtures thereof.
Claim 45
Dependent Claim
32 words
The therapeutic composition of claim 42 wherein said barbiturates is selected from the group consisting of secobarbital sodium, phenobarbital, amobarbital, pentobarbital, pentobarbital and carbomel, mephobarbital, secobarbital and amobarbital, butabarbital, and mixtures thereof.
Claim 46
Dependent Claim
13 words
The therapeutic composition of claim 21 wherein said therapeutic composition is lithium carbonate.
Claim 47
Dependent Claim
12 words
The therapeutic composition of claim 21 wherein said therapeutic composition is methylphenidate.
Claim 48
Dependent Claim
27 words
The therapeutic composition of claim 21 wherein said therapeutic composition is an anticonvulsant selected from the group consisting of phengtoin, sodium, mephenytoin, paramethadione, trimethadione, and mixtures thereof.
Claim 49
Dependent Claim
26 words
The therapeutic composition of claim 21 wherein said therapeutic composition is an antiparkinson selected from the group consisting of trihexyphenidyl, procyclidine HCI, benztropine, and mixtures thereof.
Claim 50
Dependent Claim
28 words
The therapeutic composition of claim 21 wherein said therapeutic composition is an antidepressant selected from the group consisting of tricyclics, doxepin, MAO inhibitors, protriptyline HCI, and mixtures thereof.
Claim 51
Dependent Claim
25 words
The therapeutic composition of claim 48 wherein said tricyclics is selected from the group consisting of amitriptyline, imipramine, nortriptyline HCI, desipramine HCI, and mixtures thereof.
Claim 52
Dependent Claim
24 words
The therapeutic composition of claim 48 wherein said MAO inhibitors is selected from the group consisting of tranylcypromine, isocarboxazid, nialamid, phenelzine, and mixtures thereof.
Claim 53
Dependent Claim
24 words
The therapeutic composition of claim 21 wherein said therapeutic composition is an anorexic selected from the group consisting of amphetamines, non-amphetamines, and mixtures thereof.
Claim 54
Dependent Claim
27 words
The therapeutic composition of claim 51 wherein said amphetamines is selected from the group consisting of amphetamine sulfate, dextro amphetamine, levo amphetamine, methamphetamine HIC, and mixtures thereof.
Claim 55
Dependent Claim
25 words
The therapeutic composition of claim 51 wherein said non-amphetamines is selected from the group consisting of phentermine resin, diethylproprion, phenmetazine HCI, mazindol, and mixtures thereof.
References Cited (Backward Citations)
US2957804A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-11-19 | 1983-05-21 | 1983-11-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-11-19 | 1987-05-21 | 1987-11-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-11-19 | 1991-05-21 | 1991-11-20 | $7700.00 | Window Closed / Lapsed |