US4172094A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polyamine compounds
Assignee: Merck and Co Inc
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Filing: 1976-12-03
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Granted: 1979-10-23
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Expires: 1996-12-03
Abstract
Abstract Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
Inventors
- 👤 Richard A. Dybas
- 👤 Nathaniel Grier
- 👤 Bruce E. Witzel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:50
CPC Classifications
A; A61; A61Q; A61Q11/00; A01; A01N; A01N33/00; A01N33/02; A01N33/04; A01N33/08; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/41; A61Q17/00; A61Q17/005; A61Q19/00; C; C07; C07C; C07C45/00; C07C45/42; C07C45/45; C07C45/48
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
115 words
A compound of the formula: ##STR10## where R is hydrogen or loweralkyl; each R 1 is alike or different and is C 1 to C 4 alkylene; ##STR11## and R 2 is 2-hydroxy-1,3-trimethylene, or R 1 as previously defined; R 3 is hydrogen, C 1 to C 4 alkyl, C 2 to C 4 aminoalkyl, C 1 to C 4 hydroxyalkyl, or C 2 to C 4 dihydroxyalkyl; R 4 is 2-hydroxy-1,3-trimethylene, or R 1 as previously defined; R 5 is hydrogen, aminoethyl, aminopropyl, C 1 to C 4 hydroxyalkyl, or C 2 to C 4 dihydroxyalkyl; and R 6 is hydrogen, C 1 to C 4 hydroxyalkyl or C 2 to C 4 dihydroxyalkyl.
Claim 2
Dependent Claim
115 words
A compound of the formula: ##STR10## where R is hydrogen or loweralkyl; each R 1 is alike or different and is C 1 to C 4 alkylene; ##STR11## and R 2 is 2-hydroxy-1,3-trimethylene, or R 1 as previously defined; R 3 is hydrogen, C 1 to C 4 alkyl, C 2 to C 4 aminoalkyl, C 1 to C 4 hydroxyalkyl, or C 2 to C 4 dihydroxyalkyl; R 4 is 2-hydroxy-1,3-trimethylene, or R 1 as previously defined; R 5 is hydrogen, aminoethyl, aminopropyl, C 1 to C 4 hydroxyalkyl, or C 2 to C 4 dihydroxyalkyl; and R 6 is hydrogen, C 1 to C 4 hydroxyalkyl or C 2 to C 4 dihydroxyalkyl.
Claim 3
Dependent Claim
11 words
A compound according to claim 1 where R 1 is methylene.
Claim 4
Dependent Claim
11 words
A compound according to claim 1 where R 1 is ethylene.
Claim 5
Dependent Claim
11 words
A compound according to claim 1 where R 1 is trimethylene.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 where Z is ##STR12##
Claim 7
Dependent Claim
16 words
A compound according to claim 1 where Z is --(CH 2 ) 2 NH 2 .
Claim 8
Dependent Claim
10 words
A compound according to claim 1 where Z is ##STR13##
Claim 9
Dependent Claim
16 words
A compound according to claim 1 where Z is CH 2 CHOHCH 2 NH 2 .
Claim 10
Dependent Claim
16 words
A compound according to claim 1 where Z is (CH 2 ) 3 NH 2 .
Claim 11
Dependent Claim
104 words
A compound of the formula: ##STR14## where each A is alike or different and is ##STR15## each R is alike or different and is hydrogen or loweralkyl; R 1 is methylene, ethylene, trimethylene or tetramethylene; and where Z is: --(CH 2 ) 3 NH(CH 2 ) 3 NH 2 ; --(ch 2 ) 2 nh(ch 2 ) 2 nh(ch 2 ) 2 nh 2 ; --(ch 2 ) 3 nch 3 (ch 2 ) 3 nh 2 ; --ch 2 chohch 2 nh 2 ; --(ch 2 ) 2 nh 2 ; --(ch 2 ) 3 nh 2 ; and acid addition salts thereof.
Claim 12
Dependent Claim
104 words
A compound of the formula: ##STR14## where each A is alike or different and is ##STR15## each R is alike or different and is hydrogen or loweralkyl; R 1 is methylene, ethylene, trimethylene or tetramethylene; and where Z is: --(CH 2 ) 3 NH(CH 2 ) 3 NH 2 ; --(ch 2 ) 2 nh(ch 2 ) 2 nh(ch 2 ) 2 nh 2 ; --(ch 2 ) 3 nch 3 (ch 2 ) 3 nh 2 ; --ch 2 chohch 2 nh 2 ; --(ch 2 ) 2 nh 2 ; --(ch 2 ) 3 nh 2 ; and acid addition salts thereof.
Claim 13
Dependent Claim
11 words
A compound according to claim 10 where each A is 4-isopropylphenyl.
Claim 14
Dependent Claim
11 words
A compound according to claim 10 where each A is 4-t-butylphenyl.
Claim 15
Dependent Claim
11 words
A compound according to claim 10 where each A is 2-methyl-5-t-butylphenyl.
Claim 16
Dependent Claim
11 words
A compound according to claim 10 where each A is 2,4,6-trimethylphenyl.
Claim 17
Dependent Claim
11 words
The compound according to claim 10, 1-[1,5-di-(4-isopropylphenyl)-3-pentyl]-1,5,9-triazanonane and its trihydrochloride salt.
Claim 18
Dependent Claim
11 words
The compound according to claim 10, 1-[1,7-di-(t-butylphenyl)-4-heptyl]-1,5,9-triazanonane and its trihydrochloride salt.
Claim 19
Dependent Claim
12 words
The compound according to claim 10, 1-[1,7-di-(2-methyl-5-t-butylphenyl)-4 -heptyl]-1,4,7,10-tetrazadecane and its tetrachloride salt.
Claim 20
Dependent Claim
7 words
The compound 1-[1,5-di-(4-t-butylphenyl)-3-pentyl]-1,5,9-triazanonane and its trihydrochloride salt.
Claim 21
Dependent Claim
7 words
The compound 1-[1,5-di-(4-t-butylphenyl)-3-pentyl]-1,5,9-triazanonane and its trihydrochloride salt.
Claim 22
Dependent Claim
11 words
The compound according to claim 10, 1-[1,7-di-(4-t-butylphenyl)-4-heptyl]-1,4,7,10-tetrazadecane and its tetrahydrochloride salt.
Claim 23
Dependent Claim
11 words
The compound according to claim 10, 1-[1,7-di-(2-methyl-5-t-butylphenyl)-4-heptyl]-1,5,9-triazanonane and its trihydrochloride salt.
Claim 24
Dependent Claim
11 words
The compound according to claim 10, 1-[1,7-bis-(4-t-butylphenyl)-4-heptyl]-1,5,9,13-tetrazatridecane and its tetrahydrochloride salt.
Claim 25
Dependent Claim
11 words
The compound according to claim 10, 1-[-1,5-di-(2,4,6-trimethylphenyl)-3-pentyl]-1,5,9-triazanonane and its trihydrochloride salt.
References Cited (Backward Citations)
US3876702A
Cited
US3823155A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-10-22 | 1983-04-23 | 1983-10-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-10-22 | 1987-04-23 | 1987-10-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-10-22 | 1991-04-23 | 1991-10-23 | $7700.00 | Window Closed / Lapsed |