US4172085A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Labelled bile acids
Assignee: GE Healthcare Ltd
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Filing: 1978-01-04
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Granted: 1979-10-23
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Expires: 1998-01-04
Abstract
Abstract The present invention provides compounds having the general formula ##STR1## wherein R is ##STR2## and A is 0 or 1, B is 0 to 4, C is 0 to 4, Z is Se or Te, R 6 is --OH or an amino acid residue, R 7 is hydrogen or saturated C 1 to C 4 alkyl group, when A is 1, R 8 is hydrogen or saturated C 1 to C 4 alkyl group, N is 0 or 1, R 2 , r 3 , r 4 and R 5 are independently hydrogen or an α- or β-hydroxyl group, or an oxo group, H 5 is an α- or β-H. The subject compounds, particularly the gamma emitting isotopes, are useful in the investigation of body functions.
Inventors
- 👤 Reginald Monks
- 👤 Anthony L. M. Riley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 20:40
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0493; C; C07; C07J; C07J51/00; C07J7/00; C07J7/0005; C07J9/00; C07J9/005; A61K2123/00
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
106 words
Compounds having the general formula ##STR7## wherein R is ##STR8## and A is 0 or 1, B is 0 to 4, C is 0 to 4, Z is Se or Te, R 6 is --OH or an amino acid residue, R 7 is hydrogen or saturated C 1 to C 4 alkyl group, when A is 1, R 8 is hydrogen or saturated C 1 to C 4 alkyl group, n is 0 or 1, R 2 , r 3 , r 4 and R 5 are independently hydrogen or an α- or β-hydroxyl group, or an oxo group, H 5 is an α- or β-H.
Claim 2
Dependent Claim
106 words
Compounds having the general formula ##STR7## wherein R is ##STR8## and A is 0 or 1, B is 0 to 4, C is 0 to 4, Z is Se or Te, R 6 is --OH or an amino acid residue, R 7 is hydrogen or saturated C 1 to C 4 alkyl group, when A is 1, R 8 is hydrogen or saturated C 1 to C 4 alkyl group, n is 0 or 1, R 2 , r 3 , r 4 and R 5 are independently hydrogen or an α- or β-hydroxyl group, or an oxo group, H 5 is an α- or β-H.
Claim 3
Dependent Claim
12 words
Compounds according to claim 1 wherein Z is selenium-75 or tellurium-123 m.
Claim 4
Dependent Claim
15 words
Compounds according to claim 1, wherein R 6 is a residue of glycine or taurine.
Claim 5
Dependent Claim
26 words
Compounds according to claim 1, wherein C is 0 or 1 R 7 is methyl R 8 is hydrogen n is 0 H 5 is β-H.
Claim 6
Dependent Claim
4 words
3α, 12α-dihydroxy-22-(carboxymethyl-[ 75 Se]seleno)-23,24-bisnor-5βcholane.
Claim 7
Dependent Claim
4 words
3α, 12α-dihydroxy-22-(carboxymethyl-[ 75 Se]seleno)-23,24-bisnor-5βcholane.
Claim 8
Dependent Claim
4 words
3α, 7α-dihydroxy-23-(β-carboxyetyl-[ 75 Se]seleno)-24nor-5β-cholane.
Claim 9
Dependent Claim
4 words
3α, 7α-dihydroxy-23-(β-carboxyetyl-[ 75 Se]seleno)-24nor-5β-cholane.
Claim 10
Dependent Claim
5 words
3α, 7α, 12α-trihydroxy-23-(β-carboxyethyl-[ 75 Se]seleno)-24-nor-5β-cholane.
Claim 11
Dependent Claim
5 words
3α, 7α, 12α-trihydroxy-23-(β-carboxyethyl-[ 75 Se]seleno)-24-nor-5β-cholane.
Claim 12
Dependent Claim
4 words
3α7α, 12α-trihydroxy-20-(carboxymethyl-[ 75 Se]seleno)-5βpregnane.
Claim 13
Dependent Claim
4 words
3α7α, 12α-trihydroxy-20-(carboxymethyl-[ 75 Se]seleno)-5βpregnane.
Claim 14
Dependent Claim
5 words
Glyco-22- 75 Se selenacholic acid.
Claim 15
Dependent Claim
5 words
Glyco-22- 75 Se selenacholic acid.
Claim 16
Dependent Claim
3 words
3α-hydroxy-24-(carboxymethyl- 75 Se]seleno)-5β-cholane.
Claim 17
Dependent Claim
3 words
3α-hydroxy-24-(carboxymethyl- 75 Se]seleno)-5β-cholane.
Claim 18
Dependent Claim
3 words
3α,12α-dihydroxy-23-(carboxymethyl-[ 123m Te]telluro)-24-nor-5β-cholane.
Claim 19
Dependent Claim
3 words
3α,12α-dihydroxy-23-(carboxymethyl-[ 123m Te]telluro)-24-nor-5β-cholane.
Claim 20
Dependent Claim
4 words
Tauro-23-[ 75 Se]selena-25-homodeoxycholic acid.
Claim 21
Dependent Claim
4 words
Tauro-23-[ 75 Se]selena-25-homodeoxycholic acid.
Claim 22
Dependent Claim
5 words
3, 7, 12-triketo-23-(carboxymethyl-[ 75 Se]seleno)-24-nor-5β-cholane.
Claim 23
Dependent Claim
5 words
3, 7, 12-triketo-23-(carboxymethyl-[ 75 Se]seleno)-24-nor-5β-cholane.
Claim 24
Dependent Claim
15 words
Compound according to claim 2, wherein R 6 is a residue of glycine or taurine.
Claim 25
Dependent Claim
26 words
Compound according to claim 2 wherein C is 0 or 1 R 7 is methyl R 8 is hydrogen n is 0 H 5 is β-H.
Claim 26
Dependent Claim
26 words
Compound according to claim 3 wherein C is 0 or 1 R 7 is methyl R 8 is hydrogen n is 0 H 5 is β-H.
References Cited (Backward Citations)
US3935245A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-10-22 | 1983-04-23 | 1983-10-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-10-22 | 1987-04-23 | 1987-10-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-10-22 | 1991-04-23 | 1991-10-23 | $7700.00 | Window Closed / Lapsed |