US4171311A
Expired / Lapsed
US
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Imides of thyroxin and triiodothyronine
Assignee: Lonza Walkersville Inc
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Filing: 1978-01-16
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Granted: 1979-10-16
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Expires: 1998-01-16
Abstract
Abstract New fluorescently labeled thyroxin and triiodothyronine for use in competitive binding fluorescent assays of blood sera for thyroxin and triiodothyronine are described. The new materials have the structural formula: ##STR1## in which X is H or I and R represents the atoms completing a cyclic anhydride structure.
Inventors
- 👤 Constance J. Araps
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 15:43
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; C07D493/00; C07D493/02; C07D493/10; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/74; G01N33/78; Y; Y10; Y10S; Y10S436/00; Y10S436/80
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
45 words
Compounds having the formula ##STR6## in which X is H or I and R represent the atoms completing an imide of a cyclic dicarboxylic acid selected from the group consisting of o-phthalic acid, naphthalic acid, cyclohexane dicarboxylic acid, succinic acid, maleic acid, and malic acid.
Claim 2
Dependent Claim
45 words
Compounds having the formula ##STR6## in which X is H or I and R represent the atoms completing an imide of a cyclic dicarboxylic acid selected from the group consisting of o-phthalic acid, naphthalic acid, cyclohexane dicarboxylic acid, succinic acid, maleic acid, and malic acid.
Claim 3
Dependent Claim
65 words
Fluorescently labeled thyroxin or triiodothyronine prepared by heating thyroxin or triiodothyronine with the anhydride of a vicinal cyclic dicarboxylic acid selected from the group consisting of o-phthalic acid, naphthalic acid, cyclohexane dicarboxylic acid, succinic acid, maleic acid amd malic acid to cause reaction between the anhydride and the NH 2 group of the thyroxin or triiodothyronine and then reacting the resultant imide with fluorescein amine.
Claim 4
Dependent Claim
65 words
Fluorescently labeled thyroxin or triiodothyronine prepared by heating thyroxin or triiodothyronine with the anhydride of a vicinal cyclic dicarboxylic acid selected from the group consisting of o-phthalic acid, naphthalic acid, cyclohexane dicarboxylic acid, succinic acid, maleic acid amd malic acid to cause reaction between the anhydride and the NH 2 group of the thyroxin or triiodothyronine and then reacting the resultant imide with fluorescein amine.
References Cited (Backward Citations)
US3679653A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-10-15 | 1983-04-16 | 1983-10-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-10-15 | 1987-04-16 | 1987-10-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-10-15 | 1991-04-16 | 1991-10-16 | $7700.00 | Window Closed / Lapsed |