US4168303A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Lyophilized native gamma globulin preparation for intravenous administration
Assignee: Tanabe Pharma Corp
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Filing: 1978-06-07
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Granted: 1979-09-18
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Expires: 1998-06-07
Abstract
Abstract Freeze-drying of an aqueous solution of human native gamma globulin having an anticomplementary activity of 20 (C'H50) or less in the presence of 0.06 to 0.26 part by weight of a neutral inorganic salt for 1 part by weight of the gamma globulin gives an immunoactive lyophilized native gamma globulin preparation which has undergone neither increase in anticomplementary activity nor deterioration in antibody activity during the freeze-drying and is safe for use in intravenous administration.
Inventors
- 👤 Masayuki Nishida
- 👤 Sadao Yabushita
- 👤 Shigeru Fujita
- 👤 Toshiyuki Saki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:48
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/06; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83; Y10S530/831
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
51 words
A lyophilized native gamma globulin preparation for intravenous administration consisting essentially of a human native gamma globulin which has undergone no modification having an anticomplementary activity of 20 (C'H50) or less and 0.06 to 0.26 (inclusive) part by weight of sodium chloride for 1 part by weight of the gamma globulin.
Claim 2
Dependent Claim
51 words
A lyophilized native gamma globulin preparation for intravenous administration consisting essentially of a human native gamma globulin which has undergone no modification having an anticomplementary activity of 20 (C'H50) or less and 0.06 to 0.26 (inclusive) part by weight of sodium chloride for 1 part by weight of the gamma globulin.
Claim 3
Dependent Claim
35 words
The lyophilized native gamma globulin preparation for intravenous administration according to claim 1, wherein 0 to 0.3 part by weight of human serum albumin is incorporated for 1 part by weight of the gamma globulin.
Claim 4
Dependent Claim
36 words
The lyophilized native gamma globulin preparation for intravenous administration according to claim 1 or 2, wherein 0 to 0.5 part by weight of a diluent is incorporated for 1 part by weight of the gamma globulin.
Claim 5
Dependent Claim
18 words
The lyophilized native gamma globulin preparation for intravenous administration according to claim 3, wherein the diluent is mannitol.
Claim 6
Dependent Claim
60 words
A process for producing a lyophilized native gamma globulin preparation for intravenous administration, which comprises freeze-drying an aqueous solution of human native gamma globulin which has undergone no modification having an anticomplementary activity of 20 (C'H50) or less in the presence of 0.06 to 0.26 part by weight of sodium chloride for 1 part by weight of the gamma globulin.
Claim 7
Dependent Claim
60 words
A process for producing a lyophilized native gamma globulin preparation for intravenous administration, which comprises freeze-drying an aqueous solution of human native gamma globulin which has undergone no modification having an anticomplementary activity of 20 (C'H50) or less in the presence of 0.06 to 0.26 part by weight of sodium chloride for 1 part by weight of the gamma globulin.
Claim 8
Dependent Claim
36 words
The process according to claim 5, wherein the freeze drying is carried out in the presence of 0.1 to 0.3 part by weight of human serum albumin for 1 part by weight of the gamma globulin.
Claim 9
Dependent Claim
37 words
The process according to claim 5 or 6, wherein the freeze drying is carried out in the presence of 0 to 0.5 part by weight of a diluent for 1 part by weight of the gamma globulin.
Claim 10
Dependent Claim
11 words
A process according to claim 7, wherein the diluent is mannitol.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-09-17 | 1983-03-19 | 1983-09-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-09-17 | 1987-03-19 | 1987-09-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-09-17 | 1991-03-19 | 1991-09-18 | $7700.00 | Window Closed / Lapsed |