US4166177A
Expired / Lapsed
US
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Substituted 2,2-dioxo-1,2,3-benzoxathiazines
Assignee: Merck and Co Inc
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Filing: 1977-12-27
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Granted: 1979-08-28
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Expires: 1997-12-27
Abstract
Abstract The invention relates to novel 2,2-dioxo-1,2,3-benzoxathiazines substituted in the benzene nucleus, as well as the 3,4-dihydro analogs thereof, useful as anti-inflammatory, antipyretic, analgesic agents.
Inventors
- 👤 Edward J. Cragoe, Jr.
- 👤 Robert L. Smith
- 👤 Gerald E. Stokker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 01:20
CPC Classifications
C; C07; C07D; C07D291/00; C07D291/08
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
68 words
A compound of the formula: ##STR11## wherein R 5 is hydrogen; C 1-3 alkyl; halogen; or C 1-3 alkoxy; R 6 is hydrogen; C 1-5 straight or branched chain alkyl; halogen; R 7 is hydrogen; C 1-5 alkyl; C 1-5 alkoxy; or halogen; R 8 is hydrogen; halogen; trifluoromethyl; or C 1-3 alkylthio; and the dashed line between the 3- and 4- positions describes alternative saturation or unsaturation.
Claim 2
Dependent Claim
68 words
A compound of the formula: ##STR11## wherein R 5 is hydrogen; C 1-3 alkyl; halogen; or C 1-3 alkoxy; R 6 is hydrogen; C 1-5 straight or branched chain alkyl; halogen; R 7 is hydrogen; C 1-5 alkyl; C 1-5 alkoxy; or halogen; R 8 is hydrogen; halogen; trifluoromethyl; or C 1-3 alkylthio; and the dashed line between the 3- and 4- positions describes alternative saturation or unsaturation.
Claim 3
Dependent Claim
45 words
A compound of the formula: ##STR12## wherein R 5 is hydrogen, or C 1-3 alkoxy; R 6 is hydrogen, halogen, or C 3-5 branched chain alkyl; R 7 is hydrogen or C 1-3 alkoxy; and R 8 is hydrogen, halogen, trifluoromethyl or C 1-3 alkylthio.
Claim 4
Dependent Claim
45 words
A compound of the formula: ##STR12## wherein R 5 is hydrogen, or C 1-3 alkoxy; R 6 is hydrogen, halogen, or C 3-5 branched chain alkyl; R 7 is hydrogen or C 1-3 alkoxy; and R 8 is hydrogen, halogen, trifluoromethyl or C 1-3 alkylthio.
Claim 5
Dependent Claim
40 words
A compound of the formula: ##STR13## wherein R 5 and R 7 are hydrogen or methoxy; R 6 is hydrogen, chloro, bromo, iodo, or C 3-5 branched chain alkyl; and R 8 is hydrogen, chloro, bromo, iodo, trifluoromethyl or methylthio.
Claim 6
Dependent Claim
40 words
A compound of the formula: ##STR13## wherein R 5 and R 7 are hydrogen or methoxy; R 6 is hydrogen, chloro, bromo, iodo, or C 3-5 branched chain alkyl; and R 8 is hydrogen, chloro, bromo, iodo, trifluoromethyl or methylthio.
Claim 7
Dependent Claim
3 words
The compound 2,2-dioxo-6-(1,1-dimethylethyl)-8-chloro-1,2,3-benzoxathiazine.
Claim 8
Dependent Claim
3 words
The compound 2,2-dioxo-6-(1,1-dimethylethyl)-8-chloro-1,2,3-benzoxathiazine.
Claim 9
Dependent Claim
3 words
The compound 2,2-dioxo-3,4-dihydro-6-(1,1-dimethylethyl)-8-chloro-1,2,3-benzoxathiazine
Claim 10
Dependent Claim
3 words
The compound 2,2-dioxo-3,4-dihydro-6-(1,1-dimethylethyl)-8-chloro-1,2,3-benzoxathiazine
Claim 11
Dependent Claim
3 words
The compound 2,2-dioxo-6-(1,1-dimethylethyl)-8-iodo-1,2,3-benzoxathiazine.
Claim 12
Dependent Claim
3 words
The compound 2,2-dioxo-6-(1,1-dimethylethyl)-8-iodo-1,2,3-benzoxathiazine.
Claim 13
Dependent Claim
3 words
The compound 2,2-dioxo-6-(1,1-dimethylethyl)-8-trifluoromethyl-1,2,3-benzoxathiazine.
Claim 14
Dependent Claim
3 words
The compound 2,2-dioxo-6-(1,1-dimethylethyl)-8-trifluoromethyl-1,2,3-benzoxathiazine.
Claim 15
Dependent Claim
3 words
The compound 2,2-dioxo-6-(1,1-dimethylethyl)-8-methylthio-1,2,3-benzoxathiazine.
Claim 16
Dependent Claim
3 words
The compound 2,2-dioxo-6-(1,1-dimethylethyl)-8-methylthio-1,2,3-benzoxathiazine.
Claim 17
Dependent Claim
3 words
The compound 2,2-dioxo-6-(1,1-dimethylethyl)-8-bromo-1,2,3-benzoxathiazone.
Claim 18
Dependent Claim
3 words
The compound 2,2-dioxo-6-(1,1-dimethylethyl)-8-bromo-1,2,3-benzoxathiazone.
Claim 19
Dependent Claim
3 words
The compound 2,2-dioxo-3,4-dihydro-6-(1,1-dimethylethyl)-8-iodo-1,2,3-benzoxathiazine.
Claim 20
Dependent Claim
3 words
The compound 2,2-dioxo-3,4-dihydro-6-(1,1-dimethylethyl)-8-iodo-1,2,3-benzoxathiazine.
Claim 21
Dependent Claim
3 words
The compound 2,2-dioxo-3,4-dihydro-6-(1,1-dimethylethyl)-8-trifluoromethyl-1,2,3-benzoxathiazine.
Claim 22
Dependent Claim
3 words
The compound 2,2-dioxo-3,4-dihydro-6-(1,1-dimethylethyl)-8-trifluoromethyl-1,2,3-benzoxathiazine.
Claim 23
Dependent Claim
3 words
The compound 2,2-dioxo-3,4-dihydro-6-(1,1-dimethylethyl)-8-methylthio-1,2,3-benzoxathiazine.
Claim 24
Dependent Claim
3 words
The compound 2,2-dioxo-3,4-dihydro-6-(1,1-dimethylethyl)-8-methylthio-1,2,3-benzoxathiazine.
Claim 25
Dependent Claim
3 words
The compound 2,2-dioxo-3,4-dihydro-6-(1,1-dimethylethyl)-8-bromo-1,2,3-benzoxathiazine.
Claim 26
Dependent Claim
3 words
The compound 2,2-dioxo-3,4-dihydro-6-(1,1-dimethylethyl)-8-bromo-1,2,3-benzoxathiazine.
References Cited (Backward Citations)
US3317523A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-08-27 | 1983-02-26 | 1983-08-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-08-27 | 1987-02-26 | 1987-08-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-08-27 | 1991-02-26 | 1991-08-28 | $7700.00 | Window Closed / Lapsed |