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US4166116A
Expired / Lapsed
US
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Pharmaceutical compositions containing piperazinyl acylhydroxamic acid derivatives to treat inflammation or anaphylactic allergy conditions
Assignee: University of Alberta
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Filing: 1977-11-11
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Granted: 1979-08-28
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Expires: 1997-11-11
Abstract
Abstract Compounds of the following general formula have been found to have biological activity and are useful in pharmaceutical compositions: ##STR1## wherein M = 0, 1 OR 2 R = alkylene straight or branched chain of up to 3 carbon atoms, and X when present is a salt-forming acid. Typical compounds are 2-methyl-3-{1-(4-phenyl) piperazinyl} propionohydroxamic acid monohydrochloride and {1-(4-phenethyl) piperazinyl} acetohydroxamic acid dihydrochloride. These compounds have been found to have at least one of anti-inflammatory, anti-anaphylactic and anti-depressant activity.
Inventors
- 👤 Ronald T. Coutts
- 👤 David F. Biggs
- 👤 Frank W. Wandelmaier
- 👤 Frank D. Semaka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 15:08
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/14; C07D295/145; C07D295/15; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
70 words
A method of treating inflammation or, anaphylactic allergy conditions comprising administering to an animal subject to at least one of these conditions a piperazinyl acylhydroxamic acid derivative having the following general formula ##STR5## where m=0, 1, or 2 R=alkylene straight or branched chains of up to 3 carbon atoms, and X when present is a salt-forming acid, the compound being administered in sufficient amounts to bestow anti-inflammatory or, anti-allergic activity.
Claim 2
Independent Claim
70 words
A method of treating inflammation or, anaphylactic allergy conditions comprising administering to an animal subject to at least one of these conditions a piperazinyl acylhydroxamic acid derivative having the following general formula ##STR5## where m=0, 1, or 2 R=alkylene straight or branched chains of up to 3 carbon atoms, and X when present is a salt-forming acid, the compound being administered in sufficient amounts to bestow anti-inflammatory or, anti-allergic activity.
Claim 3
Dependent Claim
17 words
The method of claim 1 wherein the compound is administered parenterally in a physiologically acceptable liquid carrier.
Claim 4
Dependent Claim
33 words
The method of claim 1 wherein the compound is selected from the group consisting of: 2-methyl-3-{1-(4-phenyl)piperazinyl}propionohydroxamic acid 2-methyl-3-{1-(4-phenethyl)piperazinyl}propionohydroxamic acid 3-methyl-3-{1-(4-phenyl)piperazinyl}propionohydroxamic acid 4-{1-(4-phenyl)-piperazinyl}butyrohydroxamic acid 3-{1-(4-phenyl)-piperazinyl}propionohydroxamic acid 4-{1-(4-phenethyl)-piperazinyl}-butyrohydroxamic acid {1-(4-phenethyl)-piperazinyl}acetohydroxamic acid or hydrochloride salts thereof.
Claim 5
Dependent Claim
58 words
A therapeutic composition comprising a physiological saline pharmaceutical carrier; and piperazinyl acylhydroxamic acid derivatives having the following general formula: ##STR6## where m=0, 1 or 2 R=alkylene straight or branched chain of up to 3 carbon atoms, and X when present is a salt-forming acid, the compound being present in sufficient amounts to bestow anti-inflammatory or anti-anaphylactic allergy activity.
Claim 6
Dependent Claim
58 words
A therapeutic composition comprising a physiological saline pharmaceutical carrier; and piperazinyl acylhydroxamic acid derivatives having the following general formula: ##STR6## where m=0, 1 or 2 R=alkylene straight or branched chain of up to 3 carbon atoms, and X when present is a salt-forming acid, the compound being present in sufficient amounts to bestow anti-inflammatory or anti-anaphylactic allergy activity.
Claim 7
Dependent Claim
19 words
The composition of claim 4 wherein the compound's phenyl or phenalkyl moiety is one of phenyl, benzyl and phenethyl.
Claim 8
Dependent Claim
17 words
The composition of claim 4 wherein the compound's acyl moiety is one of aceto, propiono and butyro.
Claim 9
Dependent Claim
17 words
The composition of claim 4 wherein the salt-forming acid X is present as the mono- or di-hydrochloride.
Claim 10
Dependent Claim
12 words
A composition of claim 4 including 2-methyl-3-{1-(4-phenyl)piperazinyl}propionohhydroxamic acid or hydrochloride salt thereof.
Claim 11
Dependent Claim
12 words
A composition of claim 4 including 2-methyl-3-{1-(4-phenethyl)piperazinyl}propionohydroxamic acid or hydrochloride salt thereof.
Claim 12
Dependent Claim
12 words
A composition of claim 4 including 3-methyl-3-{1-(4-phenyl)piperazinyl}propionohydroxamic acid or hydrochloride salt thereof.
Claim 13
Dependent Claim
12 words
A composition of claim 4 including 4-{1-(4-phenyl)piperazinyl}butyrohydroxamic acid or hydrochloride salt thereof.
Claim 14
Dependent Claim
12 words
A composition of claim 4 including 3-{1-(4-phenyl)piperazinyl}propionohydroxamic acid or hydrochloride salt thereof.
Claim 15
Dependent Claim
12 words
A composition of claim 4 including 4-{1-(4-phenethyl)piperazinyl}-butyrohydroxamic acid or hydrochloride salt thereof.
Claim 16
Dependent Claim
12 words
A composition of claim 4 including {1-(4-phenethyl)piperazinyl}acetohydroxamic acid or hydrochloride salt thereof.
Claim 17
Dependent Claim
19 words
The composition of claim 4 wherein the compound is present in amounts from about 0.1 to about 10% wt.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-08-27 | 1983-02-26 | 1983-08-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-08-27 | 1987-02-26 | 1987-08-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-08-27 | 1991-02-26 | 1991-08-28 | $7700.00 | Window Closed / Lapsed |