US4164564A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ointment and cream bases capable of withstanding elevated temperatures
Assignee: ER Squibb and Sons LLC
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Filing: 1978-08-04
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Granted: 1979-08-14
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Expires: 1998-08-04
Abstract
Abstract Non-rancid absorption ointment bases are provided which have a high capacity for water absorbability and are capable of withstanding elevated temperatures and are formed of gelled mineral oil and an ester of non-rancid isostearic acid such as sorbitan triisostearate, sorbitan sesqui-isostearate, or triglyceryl diisostearate, or an ether of non-rancid isostearyl alcohol such as polyethylene glycol diisostearate. Water-in-oil non-rancid creams resulting from the incorporating of water or medicinal solutions into the above bases are also provided and are capable of withstanding elevated temperatures. The above ointments and creams may be employed as carriers for medicaments such as antibiotics, anti-bacterial agents, antihistamines, anti-fungal agents and the like.
Inventors
- 👤 James L. Chen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 06:32
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/39; A61K8/02; A61K8/04; A61K8/042; A61K8/06; A61K8/064; A61K8/19; A61K8/27; A61K8/31; A61K8/34; A61K8/347; A61K8/36; A61K8/368; A61K8/40; A61K8/49; A61K8/4906; A61K8/4926; A61K8/4973; A61K8/60; A61K8/72; A61K8/81; A61K8/8105; A61K8/8111; A61K8/84; A61K8/86; A61Q; A61Q19/00; A61Q11/00; A61Q17/00; A61Q17/005; A61Q19/02; Y; Y10; Y10S; Y10S424/00; Y10S424/05
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
97 words
A gelled mineral oil vehicle for medicinals said vehicle having improved high temperature stability and water-absorption properties, comprising a gelled mineral oil and containing a water absorption promoter comprising an oily liquid at room temperature and free of unsaturated fatty acid moiety, and which is a member selected from the group consisting of triglyceryl diisostearate, sorbitan sesqui-isostearate, sorbitan triisostearate, polyethylene glycol isostearyl ether, polyethylene glycol diisostearyl ether, and mixtures thereof, said vehicle being stable at temperatures of 80° C. or higher, without becoming rancid, and being capable of absorbing 2 to 10 times its weight in water.
Claim 2
Dependent Claim
97 words
A gelled mineral oil vehicle for medicinals said vehicle having improved high temperature stability and water-absorption properties, comprising a gelled mineral oil and containing a water absorption promoter comprising an oily liquid at room temperature and free of unsaturated fatty acid moiety, and which is a member selected from the group consisting of triglyceryl diisostearate, sorbitan sesqui-isostearate, sorbitan triisostearate, polyethylene glycol isostearyl ether, polyethylene glycol diisostearyl ether, and mixtures thereof, said vehicle being stable at temperatures of 80° C. or higher, without becoming rancid, and being capable of absorbing 2 to 10 times its weight in water.
Claim 3
Dependent Claim
26 words
The vehicle as defined in claim 1 wherein said promotor is selected from the group consisting of sorbitan sesqui-isostearate, triglyceryl diisostearate, sorbitan triisostearate, and mixtures thereof.
Claim 4
Dependent Claim
28 words
The vehicle as defined in claim 1 wherein said promoter is selected from the group consisting of polyethylene glycol isostearyl ether, polyethylene glycol diisostearyl ether, and mixtures thereof.
Claim 5
Dependent Claim
24 words
The vehicle as defined in claim 1 wherein said promoter is present in an amount at least about 0.5% by weight of the vehicle.
Claim 6
Dependent Claim
30 words
The vehicle as defined in claim 4 wherein said promoter is employed in an amount within the range of from about 1 to about 30% by weight of the vehicle.
Claim 7
Dependent Claim
13 words
The vehicle as defined in claim 1 in the form of an ointment.
Claim 8
Dependent Claim
14 words
The vehicle as defined in claim 1 in the form of a water-in-oil cream.
Claim 9
Dependent Claim
16 words
The vehicle as defined in claim 1 wherein said gelled mineral oil is gelled with polyethylene.
Claim 10
Dependent Claim
58 words
A method for preparing the vehicle as defined in claim 1, which comprises mixing at room temperature a gelled mineral oil with a water absorption promoter comprising an oily liquid at room temperature and free of unsaturated fatty acid moiety and which is a member selected from the group consisting of triglyceryl diisostearate, sorbitan sesqui-isostearate, and sorbitan triisostearate.
Claim 11
Dependent Claim
19 words
The method as defined in claim 9 further including the step of adding water to form a water-in-oil cream.
Claim 12
Independent Claim
97 words
A method for improving high temperature stability and water absorption properties of gelled mineral oil, which comprises admixing gelled mineral oil with a water absorption promoter comprising an oily liquid at room temperature and free of unsaturated fatty acid moiety, and which is a member selected from the group consisting of triglyceryl diisostearate, sorbitan sesqui-isostearate, sorbitan triisostearate, polyethylene glycol isostearyl ether, polyethylene glycol diisostearyl ether, and mixtures thereof, said gelled mineral oil being stable at temperatures of 80° C. or higher, without becoming rancid, and being capable of absorbing 2 to 10 times its weight in water.
Claim 13
Independent Claim
97 words
A method for improving high temperature stability and water absorption properties of gelled mineral oil, which comprises admixing gelled mineral oil with a water absorption promoter comprising an oily liquid at room temperature and free of unsaturated fatty acid moiety, and which is a member selected from the group consisting of triglyceryl diisostearate, sorbitan sesqui-isostearate, sorbitan triisostearate, polyethylene glycol isostearyl ether, polyethylene glycol diisostearyl ether, and mixtures thereof, said gelled mineral oil being stable at temperatures of 80° C. or higher, without becoming rancid, and being capable of absorbing 2 to 10 times its weight in water.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-08-13 | 1983-02-12 | 1983-08-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-08-13 | 1987-02-12 | 1987-08-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-08-13 | 1991-02-12 | 1991-08-14 | $7700.00 | Window Closed / Lapsed |