Treatment of animals with 2,6-bis(2-hydroxybenzyl)phenols to eradicate trematodes

Abstract

Abstract A process for killing internal parasites of warm blooded animals which process comprises treating the infected animal with an effective amount of a composition comprising as active ingredient a compound of the general formula I: ##STR1## wherein R 1 , R 2 and R 3 , which may be the same or different, are hydrogen, lower alkyl, lower alkenyl, lower alkanoyl, lower alkenoyl, aroyl or CH 2 COOR 4 wherein R 4 is hydrogen or lower alkyl; B, C and D, which may be the same or different, are halogen, optionally substituted lower alkyl, optionally substituted aryl, lower alkenyl, lower alkoxy, hydroxy, cyano, nitro, or COR 5 wherein R 5 is hydroxy, lower alkoxy or NR 6 R 7 wherein R 6 and R 7 , which may be the same or different, are hydrogen or lower alkyl; A, E, X, Y and Z, which may be the same or different, are hydrogen, halogen, optionally substituted lower alkyl, optionally substituted aryl, lower alkenyl, lower alkoxy, hydroxy, cyano, nitro, or COR 5 wherein R 5 is as hereinbefore defined; J and G, which may be the same or different, are hydrogen, lower alkyl, optionally substituted aryl, cyano, nitro or trichloromethyl or, together with the geminal hydrogen, the group ═CCl 2 ; or an optical isomer thereof; or a salt thereof; and wherein lower alkyl and lower alkoxy are defined as groups containing from 1 to 6 carbon atoms, lower alkenyl and lower alkanoyl are defined as groups containing from 2 to 6 carbon atoms and lower alkenoyl is defined as a group containing from 3 to 6 carbon atoms; and an inert carrier therefor.

Inventors

• 👤 Errol J. McGarry
• 👤 Bruce A. Forsyth

Bibliographic Details