US4163786A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Thiazoloisoquinolines with coronary and respiratory effects
Assignee: Chinoin Private Co Ltd
•
Filing: 1978-01-16
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Granted: 1979-08-07
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Expires: 1998-01-16
Abstract
Abstract The invention relates to new thiazoloisoquinolines of the formula (I), or pharmaceutically acceptable salts thereof, ##STR1## wherein R 1 is hydrogen, hydroxy, alkoxy or aralkoxy, R 2 is hydrogen, hydroxy, alkoxy or aralkoxy, R 3 is hydrogen, cyano, alkyl, aryl, nitro, carboxy, carboalkoxy or carboxamido, and Y is oxygen, sulfur, or a group of the formula ═N--R 4 , wherein R 4 stands for hydrogen, alkyl, aryl, acyl, alkyl-sulfonyl or arysulfonyl. These new compounds can be used in practice as heart medicines or respiratory analeptics.
Inventors
- 👤 Kalman Harsanyi
- 👤 Kalman Takacs
- 👤 Pal Kiss
- 👤 Laszlo Szekeres
- 👤 Gyula Papp
- 👤 Eva Benedek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 11:52
CPC Classifications
C; C07; C07D; C07D513/00; C07D513/02; C07D513/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
41 words
A compound of the formula: ##STR10## or a pharmaceutically acceptable salt thereof wherein R 1 and R 2 are methoxy; R 3 is hydrogen, methyl, nitro, phenyl, carboxy or carboxamido; and Y is imino, oxo, sulfo, N-p-chlorophenylimino, acetimino, benzolylimino, or N-2-hydroxyethylimino.
Claim 2
Dependent Claim
41 words
A compound of the formula: ##STR10## or a pharmaceutically acceptable salt thereof wherein R 1 and R 2 are methoxy; R 3 is hydrogen, methyl, nitro, phenyl, carboxy or carboxamido; and Y is imino, oxo, sulfo, N-p-chlorophenylimino, acetimino, benzolylimino, or N-2-hydroxyethylimino.
Claim 3
Dependent Claim
33 words
The compound defined in claim 1 selected from the group consisting of: 3-imino-8,9-dimethoxy-3,4,5,6-tetrahydro-1,3-thioazolo (4,3a)iso-quinoline, or its rhodanide and hydrochloride; 1-carboxamido-3-imino-3,4,5,6-tetrahydro-3,9-dimethoxy-1,3-thiazolo(4,3a)isoquinoline; 1-methyl-3-imino-3,9-dimethoxy-3,4,5,6-tetrahydro-1,3-thiazolo(4,3a)isoquinoline and its rhodanide; 1-phenyl-3-imino-3,9-dimethoxy-3,4,5,6-tetrahydro-1,3-thiazolo(4,3a)isoquinoline and its rhodanide or hydrochloride; 1-carboxy-e-imino-3,9-dimethoxy-3,4,5,6-tetrahydro-1,3-thiazolo(4,3a)isoquinoline; and 1-carboxamido-3,9-dimethoxy-3,4,5,6-tetrahydro-1,3-thioazolo(4,3a)isoquinoline-3-one.
Claim 4
Dependent Claim
13 words
The compound defined in claim 2 selected from the group consisting of 1-carboxamido-3-imino-3,4,5,6-tetrahydro-8,9-dimethoxy-1,3-thiazolo-(4,3a)isoquinoline.
Claim 5
Dependent Claim
28 words
A method of treating angina in humans which comprises administering a compound as defined in claim 2 or a pharmaceutically acceptable salt thereof in a pharmaceutically effective dosage.
Claim 6
Dependent Claim
16 words
The method defined in claim 4 wherein the daily dosage is from 100.sup.γγ to 200.sup.γ /kg.
Claim 7
Dependent Claim
28 words
An antianginal composition for human or veterinary therapeutics containing as active ingredient an effective amount of the compound defined in claim 2 or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-08-06 | 1983-02-05 | 1983-08-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-08-06 | 1987-02-05 | 1987-08-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-08-06 | 1991-02-05 | 1991-08-07 | $7700.00 | Window Closed / Lapsed |