US4163783A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synergistic compositions and method of use to treat inflammation
Assignee: Individual
•
Filing: 1978-05-01
•
Granted: 1979-08-07
•
Expires: 1998-05-01
Abstract
Abstract The present invention relates to a novel synergistic composition and to a method of treating inflammation in warm blooded animals by topically administering to a warm blooded animal in need of such treatment an effective amount of the synergistic combination of a non-steroidal agent having anti-inflammatory activity and bis-(2-pyridyl-1-oxide) disulfide and/or at least one adduct of bis-(2-pyridyl-1-oxide) disulfide having the empirical formula: (C.sub.5 H.sub.4 NOS).sub.2 MY.sub.t (I) wherein M represents a member selected from the group consisting of zinc, iron, magnesium, tin, cadmium, zirconium, alkali and alkaline earth metals; Y is the anion of an inorganic acid and t is either 1 or 2.
Inventors
- 👤 Robert W. Klein
- 👤 George W. Nuss, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:07
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/58; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/57; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/4906; A61K8/4933; A61K8/63; A61K9/00; A61K9/06; A61Q; A61Q19/00; A61K2800/00; A61K2800/40; A61K2800/59; Y; Y10; Y10S; Y10S424/00; Y10S424/04
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
74 words
A method of treating inflammation in warm blooded animals which comprises topically administering to a warm blooded animal in need of such treatment an effective amount of a non-steroidal agent having anti-inflammatory activity selected from the group consisting of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid, d-2-(6-methoxy-2-naphthyl)propionic acid, 1-methyl-5-(4-methylbenzoyl-1)H-pyrrole-2-acetic acid, α-methyl-4-(2-methylpropyl)benzeneacetic acid, 4-(2-methylpropyl)benzeneacetic acid, α-methyl-3-phenoxybenzeneacetic acid, α,3-dichloro-4-cyclohexylphenylacetic acid, 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid and bis-2-(pyridyl-1-oxide) disulfide, said non-steroidal agent being present in the amount of 1-40% by weight of said bis-(2-pyridyl-1-oxide) disulfide.
Claim 2
Independent Claim
74 words
A method of treating inflammation in warm blooded animals which comprises topically administering to a warm blooded animal in need of such treatment an effective amount of a non-steroidal agent having anti-inflammatory activity selected from the group consisting of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid, d-2-(6-methoxy-2-naphthyl)propionic acid, 1-methyl-5-(4-methylbenzoyl-1)H-pyrrole-2-acetic acid, α-methyl-4-(2-methylpropyl)benzeneacetic acid, 4-(2-methylpropyl)benzeneacetic acid, α-methyl-3-phenoxybenzeneacetic acid, α,3-dichloro-4-cyclohexylphenylacetic acid, 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid and bis-2-(pyridyl-1-oxide) disulfide, said non-steroidal agent being present in the amount of 1-40% by weight of said bis-(2-pyridyl-1-oxide) disulfide.
Claim 3
Dependent Claim
79 words
A composition for topically treating inflammation in warm blooded animals which comprises about 0.05 to about 5% by weight of the total composition of the combination of a non-steroidal agent having anti-inflammatory activity selected from the group consisting of 1-(p-chlorobenzoyl-5-methoxy-2-methylindole-3-acetic acid, d-2-(6-methoxy-2-naphthyl)propionic acid, 1-methyl-5-(4-methylbenzoyl-1)H-pyrrole-2-acetic acid, α-methyl-4-(2-methylpropyl)benzeneacetic acid, 4-(2-methylpropyl)benzeneacetic acid, α-methyl-3-phenoxybenzeneacetic acid, α,3-dichloro-4-cyclohexylphenylacetic acid, 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid and bis-(2-pyridyl-1-oxide)disulfide together with a suitable pharmaceutical carrier, said non-steroidal agent being present in the amount of 1-40% by weight of said bis-(2-pyridyl-1-oxide) disulfide.
Claim 4
Dependent Claim
79 words
A composition for topically treating inflammation in warm blooded animals which comprises about 0.05 to about 5% by weight of the total composition of the combination of a non-steroidal agent having anti-inflammatory activity selected from the group consisting of 1-(p-chlorobenzoyl-5-methoxy-2-methylindole-3-acetic acid, d-2-(6-methoxy-2-naphthyl)propionic acid, 1-methyl-5-(4-methylbenzoyl-1)H-pyrrole-2-acetic acid, α-methyl-4-(2-methylpropyl)benzeneacetic acid, 4-(2-methylpropyl)benzeneacetic acid, α-methyl-3-phenoxybenzeneacetic acid, α,3-dichloro-4-cyclohexylphenylacetic acid, 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid and bis-(2-pyridyl-1-oxide)disulfide together with a suitable pharmaceutical carrier, said non-steroidal agent being present in the amount of 1-40% by weight of said bis-(2-pyridyl-1-oxide) disulfide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-08-06 | 1983-02-05 | 1983-08-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-08-06 | 1987-02-05 | 1987-08-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-08-06 | 1991-02-05 | 1991-08-07 | $7700.00 | Window Closed / Lapsed |