US4162305A
Expired / Lapsed
US
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Antibiotic XK-99 and process for production thereof
Assignee: Abbott Laboratories
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Filing: 1978-03-29
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Granted: 1979-07-24
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Expires: 1998-03-29
Abstract
Abstract A novel antibacterial compound, XK-99, is produced by fermentation of an organism belonging to the genus Micromonospora. The compound is isolated from the microbial cells and culture liquor.
Inventors
- 👤 Takashi Nara
- 👤 Ryo Okachi
- 👤 Isao Kawamoto
- 👤 Tomoyasu Sato
- 👤 Tetsuo Oka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:46
CPC Classifications
C; C12; C12P; C12P1/00; C12P1/06; A; A61; A61P; A61P31/00; A61P31/04; C12N; C12N1/00; C12N1/20; C12N1/205; C12R; C12R2001/00; C12R2001/01; C12R2001/29; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/867
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
66 words
XK-99, an antibacterial composition of matter characterized by: (a) a molecular weight of 390; (b) a melting point about 250° C. with decomposition; (c) Specific Rotation: α D 24 =-360° (C=0.1 methanol); (d) ultraviolet absorption spectra essentially as shown in FIG. 1; (e) infrared absorption spectrum essentially as shown in FIG. 2; and (f) a found elemental analysis of 58.24% C, 4.57% H and 9.89% N.
Claim 2
Dependent Claim
66 words
XK-99, an antibacterial composition of matter characterized by: (a) a molecular weight of 390; (b) a melting point about 250° C. with decomposition; (c) Specific Rotation: α D 24 =-360° (C=0.1 methanol); (d) ultraviolet absorption spectra essentially as shown in FIG. 1; (e) infrared absorption spectrum essentially as shown in FIG. 2; and (f) a found elemental analysis of 58.24% C, 4.57% H and 9.89% N.
Claim 3
Dependent Claim
40 words
A method for producing XK-99 as defined in claim 1 which comprises culturing a microorganism having the identifying characteristics of Micromonospora melanosporea subsp. komaensis NRRL 11,100 in a nutrient medium until substantial antibacterial activity is detected in the culture liquor.
Claim 4
Dependent Claim
15 words
A method according to claim 2 wherein said XK-99 is isolated from the culture liquor.
Claim 5
Dependent Claim
17 words
A method according to claim 2 wherein said XK-99 is isolated by extraction from the cell bodies.
Claim 6
Dependent Claim
28 words
A method according to claim 2 wherein said culturing step is carried out at from 25° to 40° C. and approximately neutral pH for 4 to 7 days.
References Cited (Backward Citations)
US3627880A
Cited
US4038383A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-07-23 | 1983-01-22 | 1983-07-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-07-23 | 1987-01-22 | 1987-07-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-07-23 | 1991-01-22 | 1991-07-24 | $7700.00 | Window Closed / Lapsed |