US4161522A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for blocking allergic responses
Assignee: University of California, San Diego
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Filing: 1978-09-07
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Granted: 1979-07-17
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Expires: 1998-09-07
Abstract
Abstract A group of relatively low molecular weight polypeptides having from 3 to 10 amino acids block the allergic response. These "blocking" polypeptides have amino acid sequences corresponding to amino acid sequences appearing in the 2nd, 3rd and 4th domains of the epsilon chain of IgE. Certain derivatives of such polypeptides also exhibit "blocking" activity. Specific active "blocking" polypeptides are disclosed and the synthesis and use thereof are described.
Inventors
- 👤 Robert N. Hamburger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:06
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0819; A; A61; A61P; A61P37/00; A61P37/08; C07K14/00; C07K14/435; C07K14/575; C07K16/00; C07K16/06; C07K16/065; C07K5/10; C07K5/1002; C07K5/1005; C07K5/1013; A61K; A61K38/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
61 words
A method for blocking the mammalian allergic reaction which method comprises administering to a host subject in an effective amount of a polypeptide comprising from 3-10 amino acids in sequence, said sequence selected from a portion of the amino acid sequence 265-537 of the Fc region of Immunoglobulin E, or the polypeptide Asp-Thr-Glu-Ala-Arg, or a pharmacologically acceptable salt or derivative thereof.
Claim 2
Independent Claim
61 words
A method for blocking the mammalian allergic reaction which method comprises administering to a host subject in an effective amount of a polypeptide comprising from 3-10 amino acids in sequence, said sequence selected from a portion of the amino acid sequence 265-537 of the Fc region of Immunoglobulin E, or the polypeptide Asp-Thr-Glu-Ala-Arg, or a pharmacologically acceptable salt or derivative thereof.
Claim 3
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Asp-Ser-Asp-Pro-Arg.
Claim 4
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Ala-Asp-Ser-Asp-Pro-Arg.
Claim 5
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Ser-Asp-Pro-Arg.
Claim 6
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Ala-Ser-Gly-Lys-Pro.
Claim 7
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Leu-Ser-Gln-Lys-His.
Claim 8
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Thr-Ala-Ser-Thr-Glu.
Claim 9
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Asp-Val-Asp-Leu-Ser.
Claim 10
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Asp-Pro-Arg.
Claim 11
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Ala-Pro-Ser-Lys-Gly-Thr.
Claim 12
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Ala-Phe-Ala-Thr-Pro.
Claim 13
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Glu-Trp-Pro-Gly-Ser.
Claim 14
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Pro-Asp-Ala-Arg-His-Ser.
Claim 15
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Ala-Ser-Pro-Ser-Gln.
Claim 16
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Asp-Val-Asp-Leu-Ser-Thr-Ala-Ser-Thr-Gln.
Claim 17
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Ala-Phe-Ala-Thr-Pro-Glu-Trp-Pro-Gly-Ser.
Claim 18
Dependent Claim
10 words
The method of claim 1 wherein the polypeptide is Asp-Thr-Glu-Ala-Arg.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-07-16 | 1983-01-15 | 1983-07-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-07-16 | 1987-01-15 | 1987-07-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-07-16 | 1991-01-15 | 1991-07-17 | $7700.00 | Window Closed / Lapsed |