US4160825A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibody-active protein composition
Assignee: University of Georgia
•
Filing: 1977-10-05
•
Granted: 1979-07-10
•
Expires: 1997-10-05
Abstract
Abstract The preparation of a novel therapeutic composition useful in the treatment of rheumatoid arthritis and other hypersensitivity diseases and a method for using said composition is described.
Inventors
- 👤 Dennis Sikes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 19:26
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/06; C07K16/065; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S424/00; Y10S424/81
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
57 words
A method for producing an antibody-active protein composition which comprises administering a spleen cell preparation from a heterologous warm blooded species to a pregnant mare to hyperimmunize the mare, removing blood from the hyperimmunized mare, separating the clear serum from the blood, and fractionating said serum by a physical-chemical procedure to separate therefrom said antibody-active protein fraction.
Claim 2
Independent Claim
57 words
A method for producing an antibody-active protein composition which comprises administering a spleen cell preparation from a heterologous warm blooded species to a pregnant mare to hyperimmunize the mare, removing blood from the hyperimmunized mare, separating the clear serum from the blood, and fractionating said serum by a physical-chemical procedure to separate therefrom said antibody-active protein fraction.
Claim 3
Dependent Claim
33 words
An antibody-active protein composition produced according to claim 1 having therapeutic properties for the treatment of rheumatoid arthritis and hypersensitivity diseases in warm blooded animals, said antibody-active protein composition being non-cytotoxic to lymphocytes.
Claim 4
Dependent Claim
19 words
A method of claim 1 wherein the physical-chemical procedure is chromatography, salting out or the employment of acridine bases.
Claim 5
Dependent Claim
17 words
A method in accordance with claim 1 wherein the spleen cell preparation is prepared from pig spleen.
Claim 6
Dependent Claim
17 words
A method in accordance with claim 1 wherein the spleen cell preparation is prepared from dog spleen.
Claim 7
Dependent Claim
17 words
A method in accordance with claim 1 wherein the spleen cell preparation is prepared from human spleen.
Claim 8
Dependent Claim
49 words
A method of treating a warm blooded animal suffering from rheumatoid arthritis or a hypersensitivity disease which comprises administering to said animal an antibody-active protein composition in accordance with claim 2 having a spleen cell agglutination titer of 1 to 3,000,000 and a protein concentration of approximately 1 percent.
Claim 9
Dependent Claim
15 words
A method in accordance with claim 7 wherein the antibody-active protein composition is administered subcutaneously.
Claim 10
Dependent Claim
15 words
A method in accordance with claim 7 wherein the antibody-active protein composition is administered intravenously.
References Cited (Backward Citations)
US3461200A
Cited
US3664994A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-07-09 | 1983-01-08 | 1983-07-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-07-09 | 1987-01-08 | 1987-07-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-07-09 | 1991-01-08 | 1991-07-10 | $7700.00 | Window Closed / Lapsed |