US4159895A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for the detection of beta thalassaemia minor
Assignee: SHINE LAN B
•
Filing: 1978-03-24
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Granted: 1979-07-03
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Expires: 1998-03-24
Abstract
Abstract Method and automatic, electronic apparatus for detecting carriers of thalassaemia, especially beta thalassaemia minor, which involve measuring the mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) of a blood sample from the subject. A descriminant preferably defined as the product (MCV) 2 MCH, the thalassaemia index is obtained and compared with a predetermined thalassaemia index threshold value.
Inventors
- 👤 Ian B. Shine
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:21
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/108331
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
87 words
A method for detecting carriers of thalassaemias, especially beta thalassaemia minor, comprising the steps of: obtaining from a blood sample the measurements of mean corpuscular volume of the red blood cells and the mean corpuscular haemoglobin; developing as a thalassaemia index value the mathematic product of said two parameter measurements; and comparing said product with a predetermined thalassaemia index threshold value, the amount that the thalassaemia index value is less than the threshold value being proportional to the probability that the sample is from a thalassaemia carrier.
Claim 2
Independent Claim
87 words
A method for detecting carriers of thalassaemias, especially beta thalassaemia minor, comprising the steps of: obtaining from a blood sample the measurements of mean corpuscular volume of the red blood cells and the mean corpuscular haemoglobin; developing as a thalassaemia index value the mathematic product of said two parameter measurements; and comparing said product with a predetermined thalassaemia index threshold value, the amount that the thalassaemia index value is less than the threshold value being proportional to the probability that the sample is from a thalassaemia carrier.
Claim 3
Dependent Claim
28 words
A method according to claim 1 including the step of conducting an A 2 determination upon at least those samples having thalassaemia index values below said threshold value.
Claim 4
Dependent Claim
14 words
A method according to claim 1 in which the predetermined threshold value approximates 1530.
Claim 5
Dependent Claim
23 words
A method according to claim 1 in which samples from males have their thalassaemia index values reduced by approximately 6.2% before said comparing.
Claim 6
Dependent Claim
31 words
A method according to claim 1 in which, in developing said thalassaemia index, it is the square of the mean corpuscular volume that forms a product with the mean corpuscular haemoglobin.
Claim 7
Dependent Claim
29 words
A method according to claim 1 in which the blood samples undergo haemoglobin electrophoresis and only samples with genotype AA are subjected to said steps of developing and comparing.
Claim 8
Dependent Claim
28 words
A method according to claim 6 including the step of conducting an A 2 determination upon at least those samples having thalassaemia index values below said threshold valve.
Claim 9
Dependent Claim
31 words
A method according to claim 7 in which, in developing said thalassaemia index, it is the square of the mean corpuscular volume that forms a product with the mean corpuscular haemoglobin.
Claim 10
Dependent Claim
14 words
A method according to claim 8 in which the pretermined threshold value approximates 1530.
Claim 11
Dependent Claim
97 words
Apparatus for use in detecting carriers of thalassaemias, especially beta thalassaemia minor, said apparatus comprising: means for obtaining from a blood sample the measurements of the parameters of the mean corpuscular volume of the red blood cells and the mean corpuscular haemoglobin; means for developing as a thalassaemia index value the mathematic product of the two parameter measurements; and means for presenting the developed thalassaemia index value so that it can be compared with at least one predetermined standard thalassaemia index value, whereby the probability of the sample being from a carrier of thalassaemia can be ascertained.
Claim 12
Dependent Claim
97 words
Apparatus for use in detecting carriers of thalassaemias, especially beta thalassaemia minor, said apparatus comprising: means for obtaining from a blood sample the measurements of the parameters of the mean corpuscular volume of the red blood cells and the mean corpuscular haemoglobin; means for developing as a thalassaemia index value the mathematic product of the two parameter measurements; and means for presenting the developed thalassaemia index value so that it can be compared with at least one predetermined standard thalassaemia index value, whereby the probability of the sample being from a carrier of thalassaemia can be ascertained.
Claim 13
Dependent Claim
20 words
Apparatus according to claim 10 in which said developing means generates as the thalassaemia index the value (MCV) 2 ×MCH.
Claim 14
Dependent Claim
34 words
Apparatus according to claim 10 in which at least said measurement obtaining means and preferably also said thalassaemia index developing means and said presenting means are parts of an automatic blood cell analyzing device.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-07-02 | 1983-01-01 | 1983-07-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-07-02 | 1987-01-01 | 1987-07-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-07-02 | 1991-01-01 | 1991-07-03 | $7700.00 | Window Closed / Lapsed |