US4158705A
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Antigen-protein complex for blocking allergic reactions
Assignee: Research Corp
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Filing: 1978-07-05
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Granted: 1979-06-19
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Expires: 1998-07-05
Abstract
Abstract A multivalent complex suitable for blocking allergic reactions comprising (1) at least one Timothy antigen D fragment having the antigenic determinant structure: <IMAGE> wherein:
Inventors
- 👤 Arthur Malley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 11:44
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/35; A61K39/36; A61P; A61P37/00; A61P37/08; C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D311/26; C07D311/28; C07D311/30; C07H; C07H17/00; C07H17/04; C07H17/06; C07H17/065; C07H17/07; A61K2039/60; A61K2039/6093; A61K2039/62; A61K2039/627; A61K38/00; Y; Y10; Y10S; Y10S424/00; Y10S424/805; Y10S530/00; Y10S530/806; Y10S530/868
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
126 words
A method of treating allergies comprising injecting into an individual an amount of a multivalent complex selected from the group consisting of: (1) a complex consisting essentially of at least one antigen D fragment bonded to a protein or peptide having the formula: ##STR10## wherein: G represents glucose; T represents threonine or a peptide linked to said structure through a threonine molecule; and R represents a peptide or protein covalently bonded to said antigen D fragment through at least one glucose moiety, (2) a quercitin-glutathione complex having the formula: ##STR11## (3) a complex consisting essentially of at least one quercitin-glutathione complex having the formula: ##STR12## covalently bonded to a protein or peptide by a peptide linkage through the glutathione moiety sufficient to inhibit antigen-induced hystamine release.
Claim 2
Independent Claim
126 words
A method of treating allergies comprising injecting into an individual an amount of a multivalent complex selected from the group consisting of: (1) a complex consisting essentially of at least one antigen D fragment bonded to a protein or peptide having the formula: ##STR10## wherein: G represents glucose; T represents threonine or a peptide linked to said structure through a threonine molecule; and R represents a peptide or protein covalently bonded to said antigen D fragment through at least one glucose moiety, (2) a quercitin-glutathione complex having the formula: ##STR11## (3) a complex consisting essentially of at least one quercitin-glutathione complex having the formula: ##STR12## covalently bonded to a protein or peptide by a peptide linkage through the glutathione moiety sufficient to inhibit antigen-induced hystamine release.
Claim 3
Dependent Claim
55 words
A method of treating allergies according to claim 1 wherein said complex has the structural formula: ##STR13## wherein: G represents glucose; T represents threonine or a peptide linked to said structure through a threonine molecule; and R represents a peptide or protein covalently bonded to said antigen D fragment through at least one glucose moiety.
Claim 4
Dependent Claim
17 words
A method of treating allergies according to claim 1 wherein said complex has the structural formula: ##STR14##
Claim 5
Dependent Claim
32 words
A method of treating allergies according to claim 1 wherein said complex has the structural formula: ##STR15## covalently bonded to a protein or peptide by a peptide linkage through the glutathione moiety.
Claim 6
Dependent Claim
122 words
An injectable composition suitable for blocking allergic reactions containing a multi-valent complex selected from the group consisting of: (1) a complex consisting essentially of at least one antigen D fragment bonded to a protein or peptide having the formula: ##STR16## wherein G represents glucose; T represents threonine or a peptide linked to said structure through a threonine molecule; and R represents a peptide or protein covalently bonded to said antigen D fragment through at least one glucose moiety, (2) a quercitin-glutathione complex having the formula: ##STR17## (3) a complex consisting essentially of at least one quercitin-glutathione complex having the formula: ##STR18## covalently bonded to a protein or peptide by a peptide linkage through the glutathione moiety sufficient to inhibit antigen-induced hystamine release.
Claim 7
Dependent Claim
122 words
An injectable composition suitable for blocking allergic reactions containing a multi-valent complex selected from the group consisting of: (1) a complex consisting essentially of at least one antigen D fragment bonded to a protein or peptide having the formula: ##STR16## wherein G represents glucose; T represents threonine or a peptide linked to said structure through a threonine molecule; and R represents a peptide or protein covalently bonded to said antigen D fragment through at least one glucose moiety, (2) a quercitin-glutathione complex having the formula: ##STR17## (3) a complex consisting essentially of at least one quercitin-glutathione complex having the formula: ##STR18## covalently bonded to a protein or peptide by a peptide linkage through the glutathione moiety sufficient to inhibit antigen-induced hystamine release.
Claim 8
Dependent Claim
58 words
An injectable composition suitable for blocking allergic reactions according to claim 5 containing a complex having the structural formula ##STR19## wherein: G represents glucose; T represents threonine or a peptide linked to said structure through a threonine molecule; and R represents a peptide or protein covalently bonded to said antigen D fragment through at least one glucose moiety.
Claim 9
Dependent Claim
20 words
An injectable composition suitable for blocking allergic reactions according to claim 5 wherein said complex has the structural formula: ##STR20##
Claim 10
Dependent Claim
35 words
An injectable composition suitable for blocking allergic reactions according to claim 5 wherein said complex has the structural formula: ##STR21## covalently bonded to a protein or peptide by a peptide linkage through the glutathione moiety.
References Cited (Backward Citations)
No citation records indexed.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-06-18 | 1982-12-18 | 1983-06-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-06-18 | 1986-12-18 | 1987-06-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-06-18 | 1990-12-18 | 1991-06-19 | $7700.00 | Window Closed / Lapsed |