Dentifrice composition containing an abrasive coated with a cationic water soluble polymer

Claim 2

A dentifrice composition comprising: (A) from about 4% to about 95% of a coated dentifrice abrasive comprising: (a) a hard mineral substance having a hardness on the Mohs' scale of 2 or more and a particle size of from about 1 micron to about 30 microns; (b) as a coating for said hard mineral substance, from about 2% to about 25% by weight, based on the weight of said hard mineral substance, of a cationic water-soluble polymer having a charge density of at least 0.003 and a molecular weight of from about 500 to about 1,000,000, said polymer being selected from the group consisting of: (i) polyacryloxyalkyl ammonium salts; (ii) polymethacryloxyalkyl ammonium salts; (iii) polyacryloamido alkyl ammonium salts; (iv) polyalkenyl ammonium salts; (v) polyvinyloxy ammonium salts; (vi) polyvinylbenzyl ammonium salts; (vii) polydiallyl ammonium salts; (viii) polyvinyl pyridinium ammonium salts; (ix) polyvinylimidazolium salts; (x) polyalkylation quaternaries; (xi) poly condensation quaternaries; and (B) from about 0.01% to about 5% of a cationic therapeutic agent.

Claim 3

The dentifrice composition of claim 1 wherein the amount of said cationic water-soluble polymer is from about 3% to about 15% by weight, based on the weight of said hard mineral substance.

Claim 4

The dentifrice composition of claim 2 wherein the hard mineral substance is selected from the group consisting of: (A) silica; (B) calcium silicate; (C) silicon carbide; (D) alumina; (E) ilmenite; (F) hematite; (G) zirconium silicate; (H) calcium pyrophosphate; (I) calcium carbonate; (J) tricalcium phosphate; (K) dicalcium orthophosphate; and (L) insoluble metaphosphate.

Claim 5

The dentifrice composition of claim 3 wherein the hard mineral substance is an amorphous silica.

Claim 6

The dentifrice composition of claim 4 wherein the hard mineral substance is a silica xerogel.

Claim 7

The dentifrice composition of claim 3 wherein the cationic water-soluble polymer is selected from the group consisting of: ##STR14## where n is the number of repeating monomeric groups and is selected so as to give a polymeric molecular weight of from 500 to 1,000,000, R 1 is either H or CH 3 , x is from 2 to about 5, R 2 , R 3 and R 4 are the same or different alkyl radicals of from 1 to 4 carbon atoms or an arvl radical, and X - is a halide ion or HSO 4 - or CH 3 SO 4 - , ##STR15## where x=1-14, n is the number of repeating monomeric groups, and is selected so as to give a polymeric molecular weight of from 500 to 1,000,000, R 1 and R 2 are CH 3 , and X - is a halide ion, ##STR16## where x=2-6, y=3-20, n is the number of repeating monomeric groups and is selected so as to give a polymeric molecular weight of from 500 to 1,000,000, R 1 and R 2 are CH 3 , and X - is a halide ion, ##STR17## x-1-12, n is the number of repeating monomeric groups and is selected so as to give a polymeric molecular weight of 500 to 1,000,000, and X - is a halide ion, ##STR18## x=6-10, n is the number of repeating monomeric groups and is selected so as to give a polymeric molecular weight of 500 to 1,000,000, and X - is a halide ion, ##STR19## x=6-10, n is the number of repeating monomeric groups and is selected so as to give a polymeric molecular weight of 500 to 1,000,000, and X - is a halide ion, ##STR20## n is the number of repeating monomeric groups and is selected so as to give a polymeric molecular weight of 500 to 1,000,000, and X - is a halide ion, ##STR21## n is the number of repeating monomeric groups and is selected so as to give a polymeric molecular weight of 500 to 1,000,000, and X - is a halide ion, ##STR22## n is the number of repeating monomeric groups and is selected so as to give a polymeric molecular weight of 500 to 1,000,000, and X - is a halide ion, ##STR23## where n is an integer varying from 4 to 40.

Claim 8

The dentifrice composition of claim 6 wherein the cationic water-soluble polymer has the structure: ##STR24## where n is an integer varying from 4 to 40.

Claim 9

The dentifrice composition of claim 3 wherein the cationic therapeutic agent is selected from the group consisting of bis-biguanide compounds and water-soluble salts of therapeutically active metallic cations.

Claim 10

The dentifrice composition of claim 8 wherein the cationic therapeutic agent is a bis-biguanide compound.

Claim 11

The dentifrice composition of claim 9 wherein the bis-biguanide compound is [1,6-di-(N 1 ,N 1 '-p-chlorophenyldiguanido-N 5 , N 5 ')-hexane] or one of its pharmaceutically acceptable salts.

Claim 12

The dentifrice composition of claim 8 wherein the cationic therapeutic agent is a water-soluble salt of a metallic cation selected from the group consisting of the water-soluble salts of indium, stannous, calcium, strontium, antimony, molybdenum, titanium and gold.