US4154833A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antiphlogistic pharmaceutical composition and method of use
Assignee: TRITON ASSOCIATES 681 MARKET ST SUITE 981 SAN FRANCISCO CA A LP
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Filing: 1978-02-17
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Granted: 1979-05-15
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Expires: 1998-02-17
Abstract
Abstract Pharmaceutical compositions containing a non-steroidal anti-inflammatory compound and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b]-[1, 4]benzodiazepin-6-one or a non-toxic acid addition salt thereof, and a method of using the same as antiphlogistics; the pyridobenzodiazepinone ingredient effectively suppresses the gastro-intestinal side-effects of the anti-inflammatory ingredient.
Inventors
- 👤 Oswald Tauber
- 👤 Gunther Engelhardt
- 👤 Matyas Leitold
- 👤 Gunther Schmidt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 07:01
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/55; A61K31/60; A61P; A61P29/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
48 words
The method of suppressing the undesirable gastro-intestinal side-effects produced by administering an effective antiphlogistic amount of 1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid to a warm-blooded animal in need thereof, which comprises simultaneous administering to said animal 1 part by weight of 5,11-dehydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one per 2 to 500 parts by weight of 1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid.
Claim 2
Independent Claim
48 words
The method of suppressing the undesirable gastro-intestinal side-effects produced by administering an effective antiphlogistic amount of 1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid to a warm-blooded animal in need thereof, which comprises simultaneous administering to said animal 1 part by weight of 5,11-dehydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one per 2 to 500 parts by weight of 1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid.
Claim 3
Dependent Claim
57 words
An antiphlogistic pharmaceutical composition consisting essentially of an inert pharmaceutical carrier, an effective antiphlogistic amount of 1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one or a non-toxic, pharmaceutically acceptable acid addition salt thereof, where the weight ratio of 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one or a non-toxic, pharmaceutically acceptable acid addition salt thereof to 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid is within the range of 1:500 parts to 1:2 parts.
Claim 4
Dependent Claim
57 words
An antiphlogistic pharmaceutical composition consisting essentially of an inert pharmaceutical carrier, an effective antiphlogistic amount of 1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one or a non-toxic, pharmaceutically acceptable acid addition salt thereof, where the weight ratio of 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one or a non-toxic, pharmaceutically acceptable acid addition salt thereof to 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid is within the range of 1:500 parts to 1:2 parts.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-14 | 1982-11-13 | 1983-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-14 | 1986-11-13 | 1987-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-14 | 1990-11-13 | 1991-05-15 | $7700.00 | Window Closed / Lapsed |