Cephalosporins having an α-acylaminoacetic acid side chain

Claim 1

A compound of the formula ##STR16## wherein R 1 denotes phenyl, thienyl, furyl, 1,4-cyclohexadienyl, or hydroxy phenyl, R 2 represents a free carboxyl group, R 3 represents heterocyclylthiomethyl, wherein heterocyclyl has 5 ring members is of aromatic character, comprises as hetero atoms 2 nitrogen atoms and a further oxygen or sulphur atom or 1 to 2 further nitrogen atoms, such a heterocyclus being unsubstituted or substituted by lower alkyl with 1-5 carbon atoms, lower alkoxy or lower alkylthio with 1-5 carbon atoms, cycloalkyl with 3-7 carbon atoms, phenyl, or phenyl substituted by a nitro group, by lower alkyl with 1 to 5 carbon atoms, lower alkoxy with 1 to 5 carbon atoms or a halogen, thienyl, or thienyl substituted as indicated for phenyl, amino, lower alkylamino, or lower alkylamino substituted in the alkyl group by carboxyl or amino, lower alkanoylamino, or lower alkanoylamino substituted on the alkyl by carboxyl or amino, lower alkoxy carbonylamino or sulphonylamino, and B represents one of the groups B 5 or B 6 , of which B 5 represents the formula ##STR17## wherein R 14 and R 15 independently of one another denote hydrogen, halogen, a free hydroxyl or mercapto group, a lower alkoxy or a lower alkylmercapto group or a lower alkoxycarbonyloxy or a lower alkoxycarbonylmercapto group, or mono- or di-lower alkylated amino group, a lower alkanoylated amino group, or ureido group or of which B 6 represents the formula ##STR18## wherein R 14 and R 15 have the meaning mentioned under formula (B 5 ), the substituent R 14 preferably occupying the 5-position of the as-triazine ring, a tautomer, or a pharmaceutically acceptable salt thereof.