US4153714A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-Thio-5-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylic acid esters, their production and use
Assignee: Beecham Group PLC
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Filing: 1978-03-30
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Granted: 1979-05-08
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Expires: 1998-03-30
Abstract
Abstract Antibacterial agents have been prepared of the formula (II): ##STR1## wherein R 1 is a group such that CO 2 R 1 is an ester group and R 2 is a hydrocarbon of up to 7 carbon atoms optionally substituted by CN, NO 2 , OR 3 , NH.CO.R 3 or CO 2 R 3 wherein R 3 is a lower alkyl.
Inventors
- 👤 Roger J. Ponsford
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 17:33
CPC Classifications
C; C07; C07D; C07D205/00; C07D205/02; C07D205/06; C07D205/08; C07D477/00; C07D477/10; C07D477/12; C07D477/16; C07D477/20; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/553; C07F9/568
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
88 words
A compound of the formula (II): ##STR44## wherein R 1 is alkyl of 1 to 4 carbon atoms unsubstituted or substituted by alkoxyl of 1 to 4 carbon atoms or benzyl unsubstituted or substituted by alkoxyl of 1 to 4 carbon atoms, nitro or chloro and R 2 is a hydrocarbon of up to 7 carbon atoms unsubstituted or substituted by a CN, NO 2 , OR 3 , NH.CO.R 3 or CO 2 R 3 group wherein R 3 is alkyl of 1 to 4 carbon atoms.
Claim 2
Dependent Claim
88 words
A compound of the formula (II): ##STR44## wherein R 1 is alkyl of 1 to 4 carbon atoms unsubstituted or substituted by alkoxyl of 1 to 4 carbon atoms or benzyl unsubstituted or substituted by alkoxyl of 1 to 4 carbon atoms, nitro or chloro and R 2 is a hydrocarbon of up to 7 carbon atoms unsubstituted or substituted by a CN, NO 2 , OR 3 , NH.CO.R 3 or CO 2 R 3 group wherein R 3 is alkyl of 1 to 4 carbon atoms.
Claim 3
Dependent Claim
11 words
A compound according to claim 1 wherein R 2 is ethyl.
Claim 4
Dependent Claim
11 words
A compound according to claim 1 wherein R 2 is 2-acetamidoethyl.
Claim 5
Dependent Claim
11 words
A compound according to claim 1 wherein R 2 is methoxycarbonylmethyl.
Claim 6
Dependent Claim
11 words
A compound according to claim 1 wherein R 2 is phenyl.
Claim 7
Dependent Claim
11 words
A compound according to claim 1 wherein R 2 is t-butyl.
Claim 8
Dependent Claim
10 words
The compound according to claim 1 which is t-[B]butyl 3-ethylthio-5-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate.
Claim 9
Dependent Claim
23 words
A pharmaceutical composition which comprises an antibacterially effective amount of a compound according to claim 1 in combination with a pharmaceutically aceptable carrier.
Claim 10
Dependent Claim
9 words
The compound according to claim 1 which is t-butyl-3-(2-acetamidoethyl)thio-5-methyl-7-oxo-1-azabicyclo[3,2,0]-hept-2-ene-2-carboxylate.
Claim 11
Dependent Claim
9 words
The compound according to claim 1 which is t-butyl-3-(2-methoxycarbonylmethyl)thio-5-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate.
Claim 12
Dependent Claim
9 words
The compound according to claim 1 which is t-butyl-3-p-nitrophenylthio-5-methyl-7-oxo-1-azabicyclo[3,2,0]-hept-2-ene-2-carboxylate.
Claim 13
Dependent Claim
9 words
The compound according to claim 1 which is benzyl-3-p-nitrophenylthio-5-methyl-7-oxo-1-azabicyclo[3,2,0]-hept-2-ene-2-carboxylate.
Claim 14
Dependent Claim
9 words
The compound according to claim 1 which is p-nitrobenzyl-3-phenylthio-5-methyl-7-oxo-1-azabicyclo[3,2,0]-hept-2-ene-2-carboxylate.
References Cited (Backward Citations)
US3950357A
Cited
US4011216A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-07 | 1982-11-06 | 1983-05-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-07 | 1986-11-06 | 1987-05-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-07 | 1990-11-06 | 1991-05-08 | $7700.00 | Window Closed / Lapsed |